11964-Savage, Jesse

Jesse J. Savage, PhD, MS, MD

Assistant Professor of Clinical Neurological Surgery

IU Health Neuroscience Center--Goodman Hall
355 W. 16th Street, Suite 5100

Indianapolis, IN 46202
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Dr. Savage's clinical focus is multifaceted. In the area of neuro-oncology, he specializes in cranial base tumors, including pituitary tumors, meningiomas, schwannomas, and chordomas. As well, he has expertise with cerebrovascular disorders, aneurysms, arteriovenous malformations (AVMs), carotid occlusive disease, and stroke. Dr. Savage also holds an interest in the diagnosis and treatment of adult degenerative spinal disorders, spinal AVMs, neurotrauma, epilepsy, cranial nerve disorders, hydrocephalus and peripheral nerve disease. He is an active member of the American Association of Neurological Surgeons, the Congress of Neurological Surgeons, and the European Association of Neurosurgical Societies.

Dr. Savage earned both undergraduate and graduate degrees in Biology from Purdue University and his medical degree from the Indiana University School of Medicine. He completed his residency in Neurological Surgery at the University of Virginia, under the direction and mentorship of Dr. John Jane Sr. His international fellowship training in cerebrovascular and cranial base surgery was completed at the Auckland City Hospital in Auckland, New Zealand. 

Key Publications

Selected Peer-reviewed Publications

Savage J, Yaden B, Kiratipranon P, and Rhodes S. (2003). Transcriptional control during mammalian anterior pituitary development. Gene Nov;319:1-19. [PMID: 14597167]

West BE, Parker GE, Savage JJ, Kiratipranon P, Toomey KS, Beach LR, Sloop KW, and Rhodes SJ. (2004). Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor. Endocrinology Nov;145(11):4866-79. [PMID: 15271874]

Yaden B, Savage J, Hunter C, and Rhodes S. (2005). DNA recognition properties of the LHX3b LIM homeodomain transcription factor. Molecular Biology Reports Mar;32(1):1-6. [PMID: 15865204]

Bhangoo A, Hunter C, Savage J, Anhalt H, Pavlakis S, Walvoord E, Ten S, and Rhodes S. (2006). Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency. J Clin Endocrinol Metab Mar;91(3):747-53. [PMID: 16394081]

Crowell PL, Schmidt CM, Yip-Schneider MT, Savage JJ, Hertzler DA, and Cummings WO. (2006). Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. Neoplasia Jun;8(6):437-45. [PMID: 16820089]

Mullen RD, Colvin SC, Hunter CS, Savage JJ, Walvoord EC, Bhangoo AP, Ten S, Weigel J, Pfaffle RW, and Rhodes SJ (2007). Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Mol Cell Endocrinol Feb;265-266:190-5. [PMID: 17210222]

Pfäffle RW, Savage JJ, Hunter CS, Palme C, Ahlmann M, Kumar P, Bellone J, Schönau E, Korsch E, Brämswig JH, Stobbe HM, Blum WF, and Rhodes SJ. (2007). Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation. J Clin Endocrinol Metab May;92(5):1909-19.
[PMID: 17327381]

Savage JJ, Mullen RD, Sloop KW, Colvin SC, Camper SA, Franklin CL, and Rhodes SJ. (2007). Transgenic mice expressing LHX3 transcription factor isoforms in the pituitary: effects on the gonadotrope axis and sex-specific reproductive disease. J Cell Physiol Jul;212(1):105-17. [PMID: 17311285]

Savage JJ, Hunter CS, Clark-Sturm SL, Jacob TM, Pfäffle RW, and Rhodes SJ. (2007). Mutations in the LHX3 gene cause dysregulation of pituitary and neural target genes that reflect patient phenotypes. Gene Oct 1;400(1-2):44-51.
[PMID: 17616267]

Pfäffle RW, Hunter CS, Savage JJ, Duran-Prado M, Mullen RD, Neeb ZP, Eiholzer U, Hesse V, Haddad NG, Stobbe HM, Blum WF, Weigel JF, and Rhodes SJ. (2008). Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies. J Clin Endocrinol Metab Mar;93(3):1062-71. [PMID: 18073311]

Savage JJ, Casey JN, McNeill IT, Sherman JH. (2010). Neurenteric cysts of the spine. J Craniovertebr Junction Spine Jan;1(1):58-63. [PMID: 20890417]

Starke RM, Nguyen JH, Rainey J, Williams BJ, Sherman JH, Savage JJ, Yen CP, and Sheehan JP. (2011). Gamma knife surgery of meningiomas located in the posterior fossa: Factors predictive of outcome and remission.
J Neurosurgery. May;114(5):1399-409. [PMID: 21214335]

Weintraub D, Yen CP, Xu Z, Savage J, Williams B, Sheehan J (2012). Gamma knife surgery of pediatric gliomas.
J Neurosurg Pediatr Dec;10(6):471-477.
[PMID: 23061823]

Titles & Appointments

  • Assistant Professor of Clinical Neurological Surgery
  • Adjunct Clinical Assistant Professor of Otolaryngology - Head & Neck Surgery
  • Education
    2009 MD Indiana University
    2005 PhD Purdue University
    2001 MS Purdue University
    2000 BA Purdue University
  • Research

    Dr. Savage's research interests include the molecular mechanisms underpinning the development and regulation of cranial base tumors and cerebrovascular disorders. Specifically, he has authored numerous publications addressing the development and regulation of the pituitary gland and hopes to continue to investigate the molecular etiology of Cushing's Disease as well as brain arteriovenous malformations. 

    Dr. Savage is currently a principal investigtor for the PENS Study (A Placebo-controlled effectiveness in INPH Shunting (PENS) Trial. The IU School of Medicine is one of several participating sites.

  • Professional Organizations
    Alpha Omega Alpha Honor Medical Society
    American Association of Neurological Surgeons
    Congress of Neurological Surgeons
    Sigma Xi Research Society

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