The Robling laboratory focuses on anabolic pathways for bone tissue, including discovery of the molecular mechanisms by which bone tissue senses mechanical loading. Dr. Robling studies how proteins involved in the Wnt signaling cascade affect bone accumulation, and how signal transduction originating from mechanical stimulation is altered by this pathway. Trainees coming through the Robling lab will participate in all aspects of mechanobiology methods, includingin vitroresponses to mechanical stimulation (e.g., shear stress) andin vivoadaptation to mechanical loading (e.g., tibial and ulnar loading, disuse models). In addition, trainees will be trained in all of the techniques used in the lab for assessing anabolic and catabolic responses in bone tissue and cell culture, including molecular (e.g., RNA extraction, qPCR, western blotting, serum/media ELISAs), radiographic (e.g., DEXA, pQCT, microCT, planar radiography), histologic (e.g., thin and thick sectioning, staining, IHC, fluorochrome histomorphometry), and biomechanical (e.g., whole bone mechanical properties).
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