10791-Lingeman, James
Faculty

James E. Lingeman, MD

Professor of Clinical Urology

Bio

Dr. Lingeman is internationally acclaimed for his clinical expertise and research in kidney stone disease and holmium laser treatment of prostatic hypertrophy. Dr. Lingeman is an NIH funded investigator in the treatment of stone disease. Dr. Lingeman's extensive experience in lithotripsy and percutaneous surgery has earned him an international reputation as a leader in endourology. He is the founding director of the International Kidney Stone Institute.

James E. Lingeman, M.D. 
IU Health Physicians Urology 
Methodist Professional Center 1 
1801 North Senate Blvd. 
Suite 220 
Indianapolis, IN 46202 
 
(317) 962-3710 (phone)
(317) 962-8800 (fax)

Key Publications

Miller NL, Gillen DL, Williams, Jr. JC, Evan AP, Bledsoe SB, Coe FL, Worcester EM, Matlaga BR, Munch LC, Lingeman JE. A formal test of the hypothesis that idiopathic calcium oxalate stones grow on Randall’s plaque. BJU Intl 103:966-971, April 2009, [PMCID: PMC3459677]

 

Evan AP, Lingeman JE, Coe FL, Bledsoe SB, Sommer AJ, Williams, Jr. JC, Krambeck AE, and Worcester EM. Intra-tubular deposits, urine and stone composition are divergent in patients with ileostomy. Kidney Intl 76:1081-1088, August 2009, [PMID:19710630], [PMC in process]

 

Connors BA, Evan AP, Blomgren PM, Handa RK, Willis LR, Gao S, McAteer JA, Lingeman JE. Extracorporeal shock wave lithotripsy at 60 shock waves/min reduces renal injury in a porcine model. BJU Intl 104(7):1004-1008, September 2009, [PMID:19338532], [PMC2888935]

 

Krambeck AE and Lingeman JE. Percutaneous management of calyceal diverticuli. J Endo 23(10):1723-1729, October 2009, [PMID:19814580]

 

Lingeman JE, McAteer JA, Gnessin E, and Evan AP. Shock wave lithotripsy: advances in technology and technique. Nature Reviews Urology 6:660-670, December 2009, [PMCID: PMC2923385]

 

Miller NL, Williams Jr. JC, Evan AP, Bledsoe SB, Coe FL, Worcester EM, Munch LC, Handa SE, Lingeman JE. In idiopathic calcium oxalate stone formers, unattached stones show evidence of having originated as attached stones on Randall’s plaque. BJUI, 105:242-245, January 2010, [PMID:19549258], [PMC2807918]

 

Krambeck AE, Walsh RS, Denstedt JD, Preminger GM, Li J, Evans JC, Lingeman JE. A novel drug eluting ureteral stent: a prospective, randomized, multicenter clinical trial to evaluate the safety and effectiveness of a Ketorolac loaded ureteral stent. J Urol 183:1037-1043, March 2010, [PMID:20092835]

 

Dusing MW, Krambeck AE, Terry C, Matlaga BR, Miller NL, Humphreys MR, Gnessin E, Lingeman JE. Holmium laser enucleation of the prostate: efficiency gained by experience and operative technique. J Urol 184:635-640, August 2010, [PMID:20639029]

 

Coe FL, Evan AP, Lingeman JE, Worcester EM. Plaque and deposits in nine human stone diseases. Urol Res 38(4):239-247, August 2010, [PMID:20625890]

 

Krambeck AE, Handa SE, Evan AP, Lingeman JE. Profile of the brushite stone former. J Urol 184:1367-1371, October 2010, [PMCID: PMC3173741]

 

Krambeck AE, Khan NF, Jackson ME, Lingeman JE, McAteer JA, Williams JC Jr. Inaccurate reporting of mineral composition by commercial stone analysis laboratories: implications for infection and metabolic stones. J Urol 184:1543-1549, October 2010, [PMID:20728108]

 

Semins MJ, Asplin JR, Steele K, Assimos DG, Lingeman JE, Donahue S, Magnuson T, Schweitzer M, Matlaga BR. The effect of restrictive bariatric surgery on urinary stone risk factors. Urology 76(4):826-829, October 2010, [PMID:20381135]

 

Miller NL, Humphreys MR, Coe FL, Evan AP, Bledsoe SB, Handa SE, Lingeman JE. Nephrocalcinosis: re-defined in the era of endourology. Urol Res 38:421-427, December 2010, [PMID:21057942] [NIHMS515482]

 

Gdor Y, Faddegon S, Krambeck AE, Roberts WW, Faerber GJ, Teichman JMH, Lingeman JE, Wolf, Jr. JS. Multi-institutional assessment of ureteroscopic laser papillotomy for chronic flank pain associated with papillary calcifications. J Urol 185:192-197, January 2011, [PMID:21074798]

 

Rassweiler JJ, Knoll T, Kohrmann KU, McAteer JA, Lingeman JE, Cleveland RO, Bailey MR, Chaussy C. Shock wave technology and application: an update. Eur Urol 59:784-796, May 2011, [PMID:21354696]

 

Gnessin E, Mandeville JA, Handa SE, Lingeman JE. Changing composition of renal calculi in patients with musculoskeletal anomalies. J Endo 25(9):1519-1523, September 2011, [PMID:21810030]

 

Gnessin E, Mandeville JA, Handa SE, Lingeman JE. The utility of noncontrast computed tomography in the prompt diagnosis of postoperative complications after percutaneous nephrolithotomy. J Endo 26(4):347-350, April 2012, [PMID:22192107]

 

Matlaga BR, Jansen JP, Meckley LM, Byrne TW, Lingeman JE. Treatment of ureteral and renal stones: a systematic review and meta-analysis of randomized, controlled trials. J Urol 188:130-137, July 2012 [PMID: 22591962]

 

Krambeck AE, Handa SE, Lingeman JE. Experience with more than 1000 holmium laser enucleations for benign prostatic hyperplasia. J Urol 189(1 Suppl):S141-145, January 2013 [PMID: 23234620]

 

Pishchalnikov YA, McAteer JA, Williams JC Jr, Connors BA, Handa R, Lingeman JE, Evan AP. Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model. J Endourol, 27:631-639, May 2013 [PMID: 23228113]

 

Pishchalnikov YA, McAteer JA, Connors BA, Handa RK, Lingeman JE, Evan AP. Acoustic characterization and assessment of renal injury with a broad focal width electrohydraulic lithotriptor. J Acoust Soc Am 134(5):4213, November 2013

 

Worcester EM, Evan AP, Coe FL, Lingeman JE, Krambeck A, Sommers A, Philips CL, Milliner D. A test of the hypothesis that oxalate secretion produces proximal tubule crystallization in primary hyperoxaluria type 1. Am J Physiol Renal Physiol 305(11):F1574-1584, December 13 [PMID: 24089413]

 

Evan AP, Lingeman JE, Worcester EM, Sommer AJ, Phillips CL, Williams JC, Coe FL. Contrasting histopathology and crystal deposits in kidneys of idiopathic stone formers who produce hydroxyapatite, brushite, or calcium oxalate stones. Anat Rec 297(4):731-748, April 2014 [PMID: 24478243]

 

Handa RK, Evan AP, Connors BA, Johnson CD, Liu Z, Alloosh M, Sturek M, Evans-Molina C, Mandeville JA, Gnessin E, Lingeman JE. Shock wave lithotripsy targeting of the kidney and pancreas does not increase the severity of metabolic syndrome in a porcine model. J Urol 192(4):1257-1265, October 2014 [PMID: 24657667]

 

Evan AP, Worcester EM, Coe FL, Williams, Jr. JC, Lingeman JE. Mechanisms of human kidney stone formation. Urolithiasis, 43 (Suppl 1):S19-S32, January 2015 [PMID: 25108546]

 

Hyams ES, Monga M, Pearle MS, Antonelli JA, Semins MJ, Assimos DG, Lingeman JE, Pais Jr. VM, Preminger GM, Lipkin ME, Eisner BH, Shah O, Sur RL, Jufarrij PW, Matlaga BR. A prospective, multi-institutional study of flexible ureteroscopy for proximal ureteral stones < 2 cm. J Urol, 193:165-169, January 2015 [PMID: 25014576]

 

Williams JC Jr, Lingeman JE, Coe FL, Worcester EM, Evan AP. Micro-CT imaging of Randall’s plaques. Urolithiasis 43 Suppl 1:13-17, January 2015 [PMID: 25096802]

 

Bhojani N, Mandeville JA, Hameed TA, Soergel TM, McAteer JA, Williams JC Jr, Krambeck AE, Lingeman JE. Lithotriptor outcomes in a community practice setting: comparison of the LithoGold LG-380 and Storz Modulith SLX. J Urol 193:875-879, March 2015 [PMID: 25305356]

 

El Tayeb MM, Knoedler JJ, Krambeck AE, Paonessa JE, Mellon MJ, Lingeman JE. Vascular complications after percutaneous nephrolithotomy: 10 years of experience. Urology 85(4):777-781, April 2015 [PMID: 25704996]

 

Evan AP, Coe FL, Connors BA, Handa RK, Lingeman JE, Worcester EM. Mechanism by which shock wave lithotripsy can promote formation of human calcium phosphate stones. Am J Physiol Renal Physiol 308(8):F938-949, April 2015 [PMID: 25656372]

 

Evan AP, Worcester EM, Williams JC Jr, Sommer AJ, Lingeman JE, Phillips CL, Coe FL. Biopsy proven medullary sponge kidney: clinical findings, histopathology, and role of osteogenesis in stone and plaque formation. Anal Rec 298(5):865-877, May 2015 [PMID: 25615853]

 

Bhojani N, Paonessa JE, Hameed TA, Worcester EM, Evan AP, Coe FL, Borofsky MS, Lingeman JE. Nephrocalcinosis in calcium stone formers who do not have systemic disease. J Urol, 194:1308-1312, November 2015 [PMID: 25988516]

 

Lingeman JE. The era of shock wave lithotripsy is over – no. J Urol 195:16-17, January 2016 [PMID: 26475659]

 

Borofsky MS, Paonessa JE, Evan AP, Williams JC Jr, Coe FL, Worcester EM, Lingeman JE. A proposed grading system to standardize the description of renal papillary appearance at the time of endoscopy in patients with nephrolithiasis. J Endourol, 30(1):122-127, January 2016 [PMID: 26414908]

 

El Tayeb MM, Borofsky MS, Paonessa JE, Lingeman JE. Wolf Piranha versus Lumenis Versacut prostate morcellation devices: a prospective randomized trial. J Urol 195:413-417, February 2016 [PMID: 26307163]

 

Borofsky MS, Wollin DA, Reddy T, Shah O, Assimos DG, Lingeman JE. Salvage percutaneous nephrolithotomy: analysis of outcomes following initial treatment failure. J Urol 195:977-981, April 2016 [PMID: 26555954]

 

Harper JD, Cunitz BW, Dunmire B, Lee FC, Sorensen MD, Hsi RS, Thiel J, Wessells H, Lingeman JE, Bailey MR. First in human clinical trial of ultrasonic propulsion of kidney stones. J Urol 195(4 Pt 1):956-964, April 2016 [PMID: 26521719]

 

Handa RK, Lingeman JE, Bledsoe SB, Evan AP, Connors BA, Johnson CD. Erratum to: intraluminal measurement of papillary duct urine pH, in vivo: a pilot study in the swine kidney. Urolithiasis 44(3):219, June 2016 [PMID: 26946035]

 

El Tayeb MM, Jacob JM, Bhojani N, Bammerlin E, Lingeman JE. Holmium laser enucleation of the prostate in patients requiring anticoagulation. J Endourol 30(7):805-809, July 2016 [PMID: 27065437]

 

Paonessa JE, Gnessin E, Bhojani N, Williams Jr. JW, Lingeman JE. Preoperative bladder urine culture as a predictor of intraoperative stone culture results: clinical implications and relationship to stone composition. J Urol 196:769-774, September 2016 [PMID: 27038771] [PMC5867897]

 

Borofsky MS, Dauw CA, Cohen A, Williams, Jr. JC, Evan AP, Lingeman JE. Integration and utilization of modern technologies in nephrolithiasis research. Nature Reviews Urology 13(9):549-557, September 2016 [PMID: 27549355]

 

Connors BA, Evan AP, Handa RK, Blomgren PM, Johnson CD, Liu Z, Lingeman JE. Using 300 pretreatment shock waves in a voltage ramping protocol can significantly reduce tissue injury during extracorporeal shock wave lithotrispy. J Endourol 30(9):1004-1008, September 2016 [PMID: 27307070]

 

Gambaro G, Croppi E, Coe F, Lingeman J, Moe O, Worcester E, Buchholz N, Bushinsky D, Curhan GC, Ferraro PM, Fuster D, Goldfarb DS, Heilberg IP, Hess B, Lieske J, Marangella M, Milliner D, Preminger GM, Reis Santos JM, Sakhaee K, Sarica K, Siener R, Strazzullo P, Williams JC, The Consensus Conference Group. Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement. J Nephrol 29(6):715-734, December 2016 [PMID: 27456839]

 

Cohen AJ, Borofsky MS, Anderson BB, Dauw CA, Gillen DL, Gerber GS, Worcester EM, Coe FL, Lingeman JE. Endoscopic evidence that Randall’s plaque is associated with surface erosion of the renal papilla. J Endourol, 31(1):85-90, January 2017 [PMID: 27824271]

 

Williams JC Jr., Worcester E, Lingeman JE. What can the microstructure of stones tell us? Urolithiasis 45(1):19-25, February 2017 [PMID: 27913855]

 

Borofksy MS, Dauw CA, York NE, Hoovler C, Lingeman JE. Comprehensive costs associated with fiberoptic and digital flexible ureteroscopes at a high volume teaching hospital. Urology Practice 4:187-192, May 2017

 

Marien T, Kadihasanoglu M, Tangpaitoon T, York N, Blackburne AT, Abdul-Muhsin H, Borofsky MS, Krambeck AE, Humphreys MR, Lingeman JE, Miller NL. Outcomes of holmium laser enucleation of the prostate in the re-treatment setting. J Urol 197:1517-1522, June 2017 [PMID: 28043843]

 

Zhang MW, El Tayeb MM, Borofsky MS, Dauw CA, Wagner KR, Lowry PS, Bird ET, Hudson TC, Lingeman JE. Comparison of perioperative outcomes between holmium laser enucleation of the prostate and robot-assisted simple prostatectomy. J Endourol 31(9):847-850, September 2017 [PMID: 28637364]

 

York NE, Borofsky MS, Chew BH, Dauw CA, Paterson RF, Denstedt JD, Razvi H, Hadler RB, Humphreys MR, Preminger GM, Nakada SY, Krambeck AE, Miller NL, Terry C, Rawlings LD, Lingeman, JE. Randomized controlled trial comparing three different modalities of lithotrites for intracorporeal lithotripsy in percutaneous nephrolithotomy. J Endourol 31(11):1145-1151, November 2017 [PMID: 28859485]

 

Williams JC Jr, Borofsky MS, Bledsoe SB, Evan AP, Coe FL, Worcester EM, Lingeman JE. Papillary ductal plugging is a mechanisim for early stone retention in brushite stone disease. J Urol 199:186-192, January 2018 [PMID: 28822796] [PMC5871923]

 

Bhojani N, Paonessa JE, El Tayeb, MM, Williams Jr. JC, Hameed TA, Lingeman JE. Sensitivity of noncontrast computed tomography for small renal calculi with endoscopy as the gold standard. Urology 117:36-40, July 2018 [PMID: 29625137]

 

Evan AP, Coe FL, Lingeman JE, Bledsoe SB, Worcester EM. Randall’s plaque in stone formers originates in ascending thin limbs. Am J Physiol Renal Physiol. August 2018, in press [PMID: 30066583]

Titles & Appointments

  • Professor of Clinical Urology
  • Education
    1974 MD Indiana University (Iupui)
    1974 MD Indiana University
    1974 MD Indiana University
  • Research

    Stone disease

    BPH

  • Professional Organizations
    American Urologic Association
    North Central Section of the American Urologic Association
  • Board Certifications
    American Board of Urology
  • Clinical Interests

    Stone disease

    BPH

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