Dr. Pascuzzi was born in Council Bluffs, Iowa, and raised in South Bend, Indiana. He attended the public school systems including John Adams High School in South Bend and received his undergraduate degree from Indiana University in Bloomington. Later, Dr. Pascuzzi earned an MD from IU School of Medicine and completed a neurology residency and fellowship training at the University of Virginia. In 1985, he joined the faculty at IU School of Medicine and served as chairman of the Department of Neurology from 2004-2020. Dr. Pascuzzi directs the Amyotrophic Lateral Sclerosis program at IU Health and the ALSA Multidisciplinary Clinic.
Dr. Pascuzzi's professional emphasis relates to general adult clinical neurology and neurological education. His research focuses on therapeutic trials in neuromuscular diseases including ALS, myasthenia gravis and Lambert Eaton Syndrome. He has served as director of the American Board of Psychiatry and Neurology (chairman of the board in 2009), past member of the Neurology Residency Review Committee of the ACGME, past editor-in-chief of Seminars in Neurology and past chair of the Medical/Scientific Advisory Board of the Myasthenia Gravis Foundation of America. He has been selected Outstanding Professor in Neurology by the graduating medical school class at Indiana University on 26 occasions, is past recipient of the IU School of Medicine Faculty Teaching Award and the Teaching Excellence Recognition Award by the Indiana University Board of Trustees. Also, he has received the Golden Apple Award as the outstanding professional chosen by the graduating medical school class eleven times. Dr. Pascuzzi received the national Distinguished Neurology Teaching Award from the American Neurological Association in 2001.