Faculty

Utpal Dave, MD

Associate Professor of Medicine

Address

R3 C321J
HEMO

Indianapolis, IN

Titles & Appointments

Associate Professor of Medicine
Associate Professor of Microbiology & Immunology

Education

1994 MD Northwestern University

1990 BS Northwestern University
Publications

LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia.
Layer JH; Christy M; Placek L; Unutmaz D; Guo Y; Davé UP; Molecular and cellular biology 2020 Mar 30

Ldb1 is required for Lmo2 oncogene-induced thymocyte self-renewal and T-cell Acute Lymphoblastic Leukemia.
Li L; Mitra A; Cui K; Zhao B; Choi S; Lee J; Stamos DB; El-Khoury D; Warzecha C; Pfeifer K; Hardwick J; Zhao K; Venters B; Dave UP; Love PE; 2020 Mar 16

Genomic Profiling of T-Cell Neoplasms Reveals Frequent <i>JAK1</i> and <i>JAK3</i> Mutations With Clonal Evasion From Targeted Therapies.
Greenplate A; Wang K; Tripathi RM; Palma N; Ali SM; Stephens PJ; Miller VA; Shyr Y; Guo Y; Reddy NM; Kozhaya L; Unutmaz D; Chen X; Irish JM; Davé UP; JCO precision oncology 2018 Feb 13

PI3K?/d and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.
Efimenko E; Davé UP; Lebedeva IV; Shen Y; Sanchez-Quintero MJ; Diolaiti D; Kung A; Lannutti BJ; Chen J; Realubit R; Niatsetskaya Z; Ten V; Karan C; Chen X; Califano A; Diacovo TG; Molecular cancer therapeutics 2017 Jul 17

Myeloid translocation genes differentially regulate colorectal cancer programs.
Parang B; Bradley AM; Mittal MK; Short SP; Thompson JJ; Barrett CW; Naik RD; Bilotta AJ; Washington MK; Revetta FL; Smith JJ; Chen X; Wilson KT; Hiebert SW; Williams CS; Oncogene 2016 Jun 6

Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.
Triplett TA; Cardenas KT; Lancaster JN; Hu Z; Selden HJ; Jasso GJ; Balasubramanyam S; Chan K; Li L; Chen X; Marcogliese AN; Davé UP; Love PE; Ehrlich LI; Proceedings of the National Academy of Sciences of the United States of America 2016 Feb 9

LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.
Layer JH; Alford CE; McDonald WH; Davé UP; Molecular and cellular biology 2015 Nov 23

Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.
Goodings C; Smith E; Mathias E; Elliott N; Cleveland SM; Tripathi RM; Layer JH; Chen X; Guo Y; Shyr Y; Hamid R; Du Y; Davé UP; Stem cells (Dayton, Ohio) 2015 May 27

Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides.
McGirt LY; Jia P; Baerenwald DA; Duszynski RJ; Dahlman KB; Zic JA; Zwerner JP; Hucks D; Dave U; Zhao Z; Eischen CM; Blood 2015 Jun 16

LMO2 induces T-cell leukemia with epigenetic deregulation of CD4.
Cleveland SM; Goodings C; Tripathi RM; Elliott N; Thompson MA; Guo Y; Shyr Y; Davé UP; Experimental hematology 2014 May 2

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
Smith S; Tripathi R; Goodings C; Cleveland S; Mathias E; Hardaway JA; Elliott N; Yi Y; Chen X; Downing J; Mullighan C; Swing DA; Tessarollo L; Li L; Love P; Jenkins NA; Copeland NG; Thompson MA; Du Y; Davé UP; PloS one 2014 Jan 21

Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells.
Yan L; Womack B; Wotton D; Guo Y; Shyr Y; Davé U; Li C; Hiebert S; Brandt S; Hamid R; Molecular and cellular biology 2013 Oct 7

Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia.
Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Davé UP; Stem cells (Dayton, Ohio) 2013 May

Targeting nonclassical oncogenes for therapy in T-ALL.
Subramaniam PS; Whye DW; Efimenko E; Chen J; Tosello V; De Keersmaecker K; Kashishian A; Thompson MA; Castillo M; Cordon-Cardo C; Davé UP; Ferrando A; Lannutti BJ; Diacovo TG; Cancer cell 2012 Apr 17

Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm.
Chmielecki J; Peifer M; Viale A; Hutchinson K; Giltnane J; Socci ND; Hollis CJ; Dean RS; Yenamandra A; Jagasia M; Kim AS; Davé UP; Thomas RK; Pao W; Genes, chromosomes & cancer 2011 Sep 21

FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma.
Elliott NE; Cleveland SM; Grann V; Janik J; Waldmann TA; Davé UP; Blood 2011 Aug 5

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.
Aue G; Du Y; Cleveland SM; Smith SB; Davé UP; Liu D; Weniger MA; Metais JY; Jenkins NA; Copeland NG; Dunbar CE; Blood 2011 Aug 30

Endoscopic ultrasound does not accurately stage early adenocarcinoma or high-grade dysplasia of the esophagus.
Young PE; Gentry AB; Acosta RD; Greenwald BD; Riddle M; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2010 Sep 8

A role for proapoptotic Bax and Bak in T-cell differentiation and transformation.
Biswas S; Shi Q; Matise L; Cleveland S; Dave U; Zinkel S; Blood 2010 Sep 2

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.
Davé UP; Akagi K; Tripathi R; Cleveland SM; Thompson MA; Yi M; Stephens R; Downing JR; Jenkins NA; Copeland NG; PLoS genetics 2009 May 22

Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning.
Duncan EA; Davé UP; Sakai J; Goldstein JL; Brown MS; The Journal of biological chemistry 1998 Jul 10

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.
Bungert J; Davé U; Lim KC; Lieuw KH; Shavit JA; Liu Q; Engel JD; Genes & development 1995 Dec 15

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