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Nuria Morral

Nuria Morral, PhD

Associate Professor of Medical & Molecular Genetics

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Bio

My lab is focused at understanding how nutrients and hormones influence gene expression, and elucidating the mechanisms that lead to hepatic insulin resistance.

EDUCATION

1987               B.Sc. Biology, University of Barcelona, Spain

1993               PhD Molecular Genetics, University of Barcelona, Spain

1994-1998      Postdoctoral fellow, Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

 

HONORS AND AWARDS

1994                Best Young Investigator Award on Human Genetics, Spanish Association of Human Genetics, Spain

1999-2003      Juvenile Diabetes Research Foundation International/Career Development Award

2009-2012      Member, American Society of Gene and Cell Therapy, Gene therapy of Genetic Diseases Committee

2009-2012      Standing member, American Diabetes Association Research Grant Review Committee

2011-2017      Standing Member, Gene and Drug Delivery Systems study section, NIH

2017-2018      American Society of Gene and Cell Therapy, Oligonucleotide and RNAi Therapeutics Committee Chair

 

Key Publications

Surendran S, Jideonwo VN, Merchun C, Ahn M, Murray J, Ryan J, Dunn K, Kota J, Morral N. Gene targets of mouse miR-709: regulation of distinct pools. Scientific Reports 6:18958 (2016).

Mansouri A, Pacheco-López G, Ramachandran D, Arnold M, Leitner C, Prip-Buus C, Langhans W, and Morral N. Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice. The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 308:R131-R137 (2015).

Ruiz, R., Jideonwo, V., Ahn, M., Surendran, S., Tagliabracci, VS., Hou, Y., Gamble, A., Kerner, J., Irimia-Dominguez, JM., Puchowicz, MA., DePaoli-Roach, A., Hoppel, C., Roach, P., Morral, N. Sterol Regulatory Element Binding Protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. Journal of Biological Chemistry 289:5510-5517 (2014).

Ahn, M., Witting, S.R., Ruiz, R., Saxena, R., Morral, N. Constitutive expression of shRNA in vivo triggers build up of mature hairpin molecules. Human Gene Therapy 22:1483-1497 (2011).

Ruiz, R., Witting, S.R., Saxena, R., Morral, N. Robust hepatic gene silencing for functional studies using helper-dependent adenovirus vectors. Human Gene Therapy 20:87-94 (2009).

Morral, N., Edenberg, HJ., Witting, SR., Altomonte, J., Chu, T., Brown, M. Effects of glucose metabolism on regulation of genes of fatty acid synthesis and triglyceride secretion in the liver. Journal of Lipid Research 48:1499-1510 (2007).

Morral, N. Novel targets and therapeutic strategies for type 2 diabetes. Trends in Endocrinology and Metabolism 14:169-75 (2003).

Morral, N., O’Neal, W.K., Rice, R., Leland, M., Kaplan, J., Piedra, P.A., Zhou, H., Parks, R., Velji, R., Aguilar-Cordova, E., Wadsworth, S., Graham, F.L., Kochanek, S., Carey, K.D., Beaudet, A.L. Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons.  Proceedings of the National Academy of Sciences USA (Track II) 96:12816-12821 (1999).

Connect


nmorralc@iu.edu 


(317) 278-9039 


MEDICAL & MOLECULAR GENETICS
IB 130 MMGE
Indianapolis, IN


  

Titles & Appointments

  • Associate Professor of Biochemistry & Molecular Biology