Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.
Biochemistry, 2016 Dec 20
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Peter J. Roach, PhD
Distinguished Professor
Bio
Dr. Roach hails from the United Kingdom, receiving his higher education at the University of Glasgow in Scotland. He moved to the United States for post-doctoral training in 1972 and has essentially remained in the US ever since. While his primary focus has been on research, Dr. Roach has made significant contributions to the training of both graduate and medical students while at Indiana University. His research has been funded by NIH since his arrival in 1979.
A postdoctoral position is currently available. Click for details.
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Biochemistry/Molecular Biology
635 Barnhill Drive Medical Science, Room MS406B
Indianapolis, IN 46202
Titles & Appointments
- Chancellor's Professor, IUPUI
- Professor of Biochemistry & Molecular Biology
1972
PhD
Biochemistry (PhD), University of Glasgow
1969
BSC
Biochemistry (BSC), University of Glasgow
Dr. Roach's work focuses on the metabolism of glycogen and its regulation, at the structural, cellular and whole animal level. In recent years, his work has been more directed towards genetic diseases accruing from defective glycogen metabolism, notably Lafora disease, a childhood-onset fatal epilepsy and Pompe disease, which has mainly skeletal muscle and cardiac pathology.
Glycogen phosphorylation and Lafora disease.
Molecular aspects of medicine, 2015 Aug 13
Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease.
The Journal of biological chemistry, 2014 Nov 21
Glycogen and its metabolism: some new developments and old themes.
The Biochemical journal, 2012 Feb 1
Phosphate incorporation during glycogen synthesis and Lafora disease.
Cell metabolism, 2011 Mar 2
PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease.
PLoS genetics, 2011 Apr 28
Abnormal metabolism of glycogen phosphate as a cause for Lafora disease.
The Journal of biological chemistry, 2008 Oct 13