Indiana Center for Regenerative Medicine and Engineering

Tissue Nanotransfection Techonology

Under the leadership of Chandan Sen, PhD, one of the nation’s leading experts in the field of regenerative medicine, a non-invasive, nanochip device that uses a technology called tissue nanotransfection (TNT) has been developed to reprogram one type of tissue into another with a simple touch and electric spark that is harmless to the body.  The technology has two major components: First, a nanotechnology-based chip hardware is designed to deliver cargo to adult cells in the live body. Second, the design of specific biological cargo for cell conversion allows such cargo, when delivered using the above hardware, to convert an adult cell from one type to another of interest.

Tissue nanotransfection does not require any laboratory-based procedures and may be implemented at the point of care. The procedure is also non-invasive. For example, topical contact of the nanochip hardware with the skin for less than a second is sufficient to deliver cargo to skin cells such that skin cells become vasculogenic cells.

This technology avoids the use of stem cells and is simple to use.  Tissue nanotransfection has been licensed with the ultimate goal of enabling skin and other tissue to be converted to tissue types necessary for therapy. These potential therapies include healing burns, reducing diabetic complications, treating injured soldiers, and re-growing damaged and diseased tissue.

Tissue Nanotransfection (TNT)

TNT: The simple use of complex technology

Sen and his team of interdisciplinary experts will continue to develop this technology at the Indiana Center for Regenerative Medicine and Engineering, which will involve close collaboration with the Weldon School of Biomedical Engineering as well as the Birck Nanotechnology Center, both at Purdue University.