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Faculty investigators in the Department of Obstetrics and Gynecology conduct collaborative research across a broad spectrum of women’s health issues. Investigators have been awarded numerous highly competitive grants from a variety of funding agencies, including the National Institutes of Health, and have published results from these various projects in several high impact peer-reviewed journals. In addition, some of the research findings here have contributed to practice changes worldwide in women’s health.
General Obstetrics and Gynecology
The Division of General Obstetrics and Gynecology is a leader in clinical research. Research efforts include studies of genetics and pharmacology, personalized medicine in pregnancy, prevention of pre-term birth, reversible contraceptive methods, patient-physician communication and shared decision-making and health care delivery and teaching methods. Research performed by members of this division has garnered several prestigious national awards.
Maternal Fetal Medicine
The Maternal Fetal Medicine Division has a strong record of production of basic science, clinical/translational and epidemiologic research, including membership in the Consortium on Safe Labor, Obstetric-Fetal Pharmacology Research Units Network and Nulliparous Network of the NICHD (nuMoM2b). The team also has long-standing partnerships with the prestigious Regenstrief Institute for informatics and healthcare research in Indianapolis.
This division supports a Perinatal Epigenetics Research Laboratory, which conducts translational research in gene-environment interactions that affect fetal development, maternal health and postnatal health trajectories, as well as an Obstetric Clinical Pharmacology Lab, which provides laboratory space and resources for basic and translational study techniques related to therapeutics in pregnant women.
An important component of the division’s obstetric research is the PREGMED program. One of the initial IUPUI Signature Centers and later supported by NIH funding, the focus of PREGMED is to develop personalized therapeutic approaches for pregnant women and children using analytic, genomic, and computational techniques.
In association with NRG Oncology and the Gynecologic Oncology Group Foundation, the Gynecologic Oncology Division actively participates in many different clinical trials protocols. Pre-clinical and animal studies of gynecologic malignancies focus primarily on the development and progression of gynecologic cancers at the molecular level. Discovering new and effective diagnostic and prognostic biomarkers remains the main goal of cancer-based laboratory research. Explore the list of current trials.
Building Block of Pregnancy Biobank
The Building Blocks of Pregnancy Biobank is an internally funded local pregnancy biobank. Thus far, BBPB has recruited more than 2500 subjects with more than 54,000 samples banked. This is an observational, longitudinal pregnancy biobank. The goal is to provide a resource at IU School of Medicine for investigators to look for novel biomarkers and clinical variables associated with adverse pregnancy outcomes.
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