Weinberger began his research career at Stanford University, after completing his internship and residency in Internal Medicine at IU. He was the first to identify the high doses of estrogen in birth-control pills as a cause of hypertension in women. He developed one of the first radioimmunoassays to measure renin and aldosterone in blood that enhanced research in the field of sodium metabolism. This led to many new findings of the causes and treatments of hypertension. He was also one of the first to study the newly developed classes of drugs blocking components of the renin-angiotensin-aldosterone system, as well as other new antihypertensive drugs including calcium channel and beta blockers. Six additional NIH grants investigated newer aspects of these findings leading to reduction in heart disease and stroke.
Weinberger directed the Hypertension Research Center, published over 250 peer-reviewed scientific papers and 25 books/book chapters, while conducting a busy referral practice treating hypertensive patients from the US and Europe.
To longtime friends and colleagues, Weinberger’s impact is even more extraordinary given the fact that he was born profoundly deaf and learned to read lips as well as books by the age of 4. In the third grade he obtained a hearing aid and embarked on a lifetime of adaptation, determined to become a physician despite repeated advice that it would not be possible.
“This disability did not deter his august achievements, and one must conclude that his achievements are even more remarkable by way of his perseverance and dedication to overcome any handicap to achieve academic excellence,” said Robert W. Holden, M.D., Dean Emeritus of the School of Medicine.