Center for Bioethics

TREATs Talks

The Bioethics and Subject Advocacy Program of the Indiana Clinical and Translational Sciences Institute (CTSI) at Indiana University School of Medicine presents Translational Research Ethics: Applied Topics seminars (TREATs) monthly regarding ethical issues in translational research. Access to presentations and information on research ethics presented as TREAT seminars are available.

Minor Consent to Research

Cluster Randomized Clinical Trials: Ethics and Science

On March 29, 2017, Edward Liechty, MD gave a presentation on the unique ethical issues that can arise from cluster randomized clinical trials.

Resources related to this topic:

Conflict of Interest

On September 29, 2016, Andrew Brightman, PhD gave a presentation on the conflicts of interest that can arise from partnering with medical device companies during research. This talk was titled “Does It Pay to Partner With Medical Device Companies? Considering Conflict of Interest.

Resources related to this topic:

Data Safety

Misconduct in Research

On June 29, 2017, Kim Quaid, PhD, presented insights to the ethical issues of research misconduct, including issues related to fabrication, falsification and plagiarism.

Video recording of talk

George, S. L. (2016). Research misconduct and data fraud in clinical trials: prevalence and causal factors. International journal of clinical oncology, 21(1), 15.

Seife, C. (2015). Research misconduct identified by the US Food and Drug Administration: out of sight, out of mind, out of the peer-reviewed literature. JAMA internal medicine, 175(4), 567-577.

Resnik, D. B., Neal, T., Raymond, A., & Kissling, G. E. (2015). Research misconduct definitions adopted by US research institutions. Accountability in research, 22(1), 14-21.

Resnik, D. B., Rasmussen, L. M., & Kissling, G. E. (2015). An International Study of Research Misconduct Policies. Accountability in Research, 22(5), 249–266.

Sox, H. C., & Rennie, D. (2006). Research misconduct, retraction, and cleansing the medical literature: lessons from the Poehlman case. Annals of Internal Medicine, 144(8), 609.

De-Identified Data: Ethics and Regulation

Peter Schwartz, MD presented a TREAT Talk on Data De-Identification on December 22, 2016. This seminar focused on the ethics and regulations involving de-identifying data from research in order to protect patient privacy.

Materials related to this talk include:

Incidental Findings

On June 16, 2016, Kim Quaid, PhD, gave a presentation on incidental findings from genetic testing and the ethics involving what to do with those results and whether the patient should be informed.

 Materials related to this talk include:

Gliwa, C., Yurkiewicz, I. R., Lehmann, L. S., Hull, S. C., Jones, N., & Berkman, B. E. (2015) Institutional review board perspectives on obligations to disclose genetic incidental findings to research participants. Genetics in Medicine, 18(7), 705-711.

Kleiderman, E., Avard, D., Besso, A., Ali?Khan, S., Sauvageau, G., & Hébert, J. (2015) Disclosure of incidental findings in cancer genomic research: investigators’ perceptions on obligations and barriers. Clinical Genetics, 88(4), 320-326.

Abdul-Karim, R., Berkman, B. E., Wendler, D., Rid, A., Khan, J., Badgett, T., & Hull, S. C. (2013) Disclosure of Incidental Findings From Next-Generation Sequencing in Pediatric Genomic Research. Pediatrics, 131(3), 564–571.

Meacham, M. C., Starks, H., Burke, W., & Edwards, K. (2010). Researcher Perspectives on Disclosure of Incidental Findings in Genetic Research. Journal of Empirical Research on Human Research Ethics? JERHRE, 5(3), 31–41.

Clinical Trial Recruitment

On May 19, 2016, Peter Schwartz, MD gave a presentation titled “Is it Ethical to Exclude People Who Can’t Speak English from Participating in a Study?” on the ethics surrounding exclusion of people with limited English proficiency from participating in a research study.

Materials related to this talk include: