20592-Allette, Yohance
Resident

Yohance M. Allette, MD, MD PhD, PhD

Neurology, PGY 4
Indiana University School of Medicine

Address
CL 630
RSDT
IN
Indianapolis, IN

Key Publications

Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3-glucuronide sensitization of sensory neurons. Allette YM, Kim Y, Randolph AL, Smith JA, Ripsch MS, White FA. Scientific Reports. 2017.

The HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury Induced Pulmonary Dysfunction.Weber DJ, Allette YM, Wilkes DS, White FA. Antioxidants and Redox Signaling. 2015.

Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-Products in a model of neuropathic pain. Allette YM, Due MR, Wilson SM, Feldman P, Ripsch MS, Khanna R, White FA. Brain Behav Immun. 2014.

Carbamazepine potentiates the effectiveness of morphine in a rodent model of neuropathic pain. Due MR, Xang XF, Allette YM, Randolph AL, Ripsch MS, Wilson SM, Dustrude ET, Khanna R, White FA. PLoS One. 2014.

The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation. Weber DJ, Gracon AS, Ripsch MS, Fisher AJ, Cheon BM, Pandya PH, Wittal R, Capitano ML, Kim Y, Allette YM, Riley AA, McCarthy BP, Territo PR, Hutchins GD, Broxmeyer HE, Sandusky GE, White FA, Wilkes DS. Sci Transl Med. 2014.

Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria. Tang M, Odejinmi SI, Allette YM, Vankayalapati H, Lai K.  Bioorg Med Chem. 2011.                                     

Titles & Appointments

  • Resident Appointee
  • Education
    2017 MD PhD Indiana University School of Medicine
    2017 MD Indiana University School of Medicine
    2015 PhD Indiana University School of Medicine
  • Research

    My thesis project investigated the role of HMGB1 through its receptors Receptor for Advanced Glycation End-products (RAGE) and Toll-Like Receptor 4 (TLR4) as it pertained to the development of chronic inflammation and pathology in small diameter, nociceptive sensory neurons. It was demonstrated that the neuronal signaling associated with exposure to HMGB1 is dependent upon the ligands conformational states, as the state dictates its affinity and types of neuronal response. I designed and performed the major requisite experiments and interpreted the results under the guidance of my principal investigator. I was able to identify several key signaling mechanisms involved, as well as illustrate successful pharmacologic blockade with strong therapeutic indications.

  • Awards
    Org: The Park School Graduate Student Fellows Program in Science, Mathematics, and Technology
    Desc: Celebration of Alumni in STEM fields
    Scope: School
    Date: 2017-04-01

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