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Research

Medicinal and Analytical Chemistry

Services

Cheminformatics

  • Compound Information Retrieval from Database (e.g. HTS Hits)
  • Structure-Activity Relationship (SAR) Analysis
  • Compound Novelty Analysis on Structure & Bioactivity
  • Property Evaluation on Drug Ability (e.g. CLogP, Solubility, etc.)

Medicinal Chemistry

  • Structural Design for Small Molecules, such as Inhibitors, Probes & Activators
  • Synthetic Route Design for Small Molecules
  • Compound Synthesis & Purification (Up to Gram Scale)
  • Combinatorial Small Molecule Library Design & Synthesis

Analytical Chemistry

  • Small Molecule Qualification: Structural Elucidation & Purity Determination
  • Small Molecule Quantification for Metabolites, Biomarkers, etc.
  • Protein, Peptide, & Oligonucleotide Qualification & Quantification

Hourly Rates (FY2020)

Internal user: $66
Nonprofit organization: $104
For-profit organization: $119

Synthetic and Analytical Equipment Rates

 Price FY2020  Unsupervised Price ($)  Supervised Price ($)  All Users per Unit
 Instrument  Unit  Internal  Nonprofit  For-profit  Internal  Nonprofit  For-profit  Supplies Package ($)
 Aapptec Peptide Synthesizer  per hour  16  27  30  71  112  129  44
 Biotage Microwave Reactor  per hour  10  27  30  71  112  129  18
 Chemical Hood and Space  monthly per chemist  402  634  729  402  634  729  TBD
 Agilent 1290 LC - 6545 QTOF MS  per hour  42  66  76  87  138  159  31
 Agilent 1200 LC - 6130 MS  per hour  27  44  50  82  129  149  31
 Bruker NMR, 300MHz  per hour  17  40  45  79  125  144  43
 Biotage Flash Purification System  per hour  16  27  30  71  121  129  36
 Waters Preparative HPLC  per hour  15  35  40  77  121  139  33
 Buchi Evaporation System 1  per hour  10  20  22  67  105  121  10
 Labconco Freeze Dryer  per port per day  5  20  23  67  106  122  9

 Stuart Melting Point Meter

 per hour

 10

 20

 22

 67

 105

 121

 0

Please contact Lifan Zeng, PhD, for more information.

Equipment

Chemical hoods, Lyophilizer, Melting Point Apparatus, Polarimeter, Rotary Evaporator

UHPLC/Q-ToF

Agilent LC1290 Infinity II – MS6545 Q-ToF equipped with UV detector.

  • High Resolution MS for Small Molecule and Protein Characterization
  • Identification and Verification of Metabolite Biomarkers
  • Targeted MS/MS for Quantitation, Identification, and Confirmation of Unknowns

NMR

Bruker 300 MHz Fourier Transform NMR equipped with a 16-slot automated sampler.

  • Structure Elucidation and Verification via 1D and 2D NMR
  • Purity Determination, Quality Assurance and Control

Preparative HPLC

Waters Preparative HPLC with UV detector

  • Purification of Small Molecules and Peptides

Microwave Reactor

Biotage Microwave

  • Efficient and Controlled Heating via µW irradiation
  • Accelerated Organic Reactions via High Temperature and Pressure

Flash Purification

Biotage Flash Purification with Automated Fraction Collection

Aapptec Automated Parallel Organic Synthesizer