Research

Service Cores

Research core laboratories provide investigators with specialized scientific services to support their research. With these resources, scientists at IU School of Medicine and partner organizations can access state-of-the-art instrumentation and equipment, technical expertise, and training that advances their work.

Indianapolis

The Advanced Biomedical Information Technology Core offers supercomputing, bioinformatics software, data management and database hosting, massive storage and advanced visualization services.

The Computational Biology and Bioinformatics Service Core, a service unit of the Center for Computational Biology and Bioinformatics, provides biomedical data management, informatics and analytical consulting, graphic and website design, and software and website hosting.

The Cardiovascular Ischemia and Vasculogenesis Core provides technical expertise and assistance in conducting experiments employing various rodent cardiovascular disease models for generating physiological data or for testing experimental compounds, molecules, cells or devices.

The Chemical Genomics Core provides investigators with cost-effective access to high throughput screening of structurally diverse, drug-like small molecules in biological assays to discover small molecule tools for basic research, therapeutic development and diagnostic applications.

The Indiana Institute for Biomedical Imaging Sciences offers imaging of tissue biochemistry, physiology, and anatomy provided by the Indiana Center of Excellence in Biomedical Imaging.

The Small Animal Ultrasound Core provides high resolution ultrasound for imaging of rodents and small animals. The core provides expertise, imaging facilities and off-line image analysis for investigators.

The veterinary staff and other highly experienced laboratory animal professionals of the IU School of Medicine Laboratory Animal Resource Center provides training, supplies and specialized service support for medical research. Services center on basic husbandry for a wide variety of laboratory animal species.

The Micro Computed Tomography Core houses two Skyscan systems with the versatility to scan skeletal and non-soft biological tissues at high resolution. The 1172 system has variable magnification (pixel size between 0.9-35 µm) and can hold ex vivo samples with a maximum diameter of 68 mm. With a fixed magnification (pixel size of 9, 18 or 36 µm), the system can be used for in vivo animals and ex vivo samples. Scan reconstruction and analysis software can be used on the scanning systems, or they can be installed on individual laboratory workstations. Self-service or full-service scanning is available. Scanning rates are discounted members of the Indiana Center for Musculoskeletal Health; the systems can be used by non-members as well. For more information, email the system manager or contact the core director.

The Electron Microscopy Center provides electron microscopy services utilizing either scanning or transmission electron microscopy.

The Indiana Center for Biological Microscopy offers high resolution confocal epifluorescence and multiphoton microscopy of cells, tissues and organs in living animals and fixed samples, and development of methods for imaging and digital image analysis.

The Clinical Pharmacology Analytical Core provides services to assist in the quantification of drugs and/or metabolites, identification of metabolites and pharmacokinetic analysis of data.

The Proteomics Core facility provides identification, quantitation and characterization of proteins and instrumentation development.

The Transgenic and Knockout Mouse Core provides production of transgenic mouse lines using both blastocyst injection of embryonic stem cells and pronuclear injection of DNA.

South Bend

The IU School of Medicine Imaging and Flow Cytometry Core facility, located on the school’s South Bend campus, operates a laser core facility in Raclin-Carmichael and Harper halls, which houses multiple types of laser-scanning equipment that are available to all faculty and staff of IU School of Medicine and the University of Notre Dame. The Imaging and Flow Cytometry Core is a member of the CTSI Resource Core Group.