Laboratory of Molecular Mechanisms of Auditory Perception and Deafness

Selected Publications

• 2023
  Li J, Liu C, Muller U, Zhao B (2023) Autophagy proteins are essential for aminoglycoside-induced hearing loss. Autophagy:1-2. PubMed
• 2022

  Li J, Liu C, Muller U, Zhao B (2022) RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss. Dev Cell 57:2204-2220 e2206. PubMed

  Liu C, Luo N, Zhao B (2022) Reducing Taperin Expression Restores Hearing in Grxcr2 Mutant Mice. Neuroscience 498:85-92. PubMed

  Krey JF, Liu C, Belyantseva IA, Bateschell M, Dumont RA, Goldsmith J, Chatterjee P, Morrill RS, Fedorov LM, Foster S, Kim J, Nuttall AL, Jones SM, Choi D, Friedman TB, Ricci AJ, Zhao B, Barr-Gillespie PG (2022) ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points. J Cell Biol 221. PubMed

  Li J, Liu C, Zhao B (2022) Collapsin Response Mediator Protein 1 (CRMP1) Is Required for High-Frequency Hearing. Am J Pathol 192:805-812. PubMed

  Li J, Liu C, Kaefer S, Youssef M, Zhao B (2022) The Mechanotransduction Channel and Organic Cation Transporter Are Critical for Cisplatin Ototoxicity in Murine Hair Cells. Front Mol Neurosci 15:835448. PubMed

• 2021

  Liu C, Zhao B (2021) Murine GRXCR1 Has a Different Function Than GRXCR2 in the Morphogenesis of Stereocilia. Front Cell Neurosci 15:714070. PubMed

  McGrath J, Tung CY, Liao X, Belyantseva IA, Roy P, Chakraborty O, Li J, Berbari NF, Faaborg-Andersen CC, Barzik M, Bird JE, Zhao B, Balakrishnan L, Friedman TB, Perrin BJ (2021) Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin. Curr Biol 31:1141-1153 e1147. PubMed

  Li J, Liu C, Zhao B (2021) N-Terminus of GRXCR2 Interacts With CLIC5 and Is Essential for Auditory Perception. Front Cell Dev Biol 9:671364. PubMed

• 2020

  de Bruijn SE, Smits JJ, Liu C, Lanting CP, Beynon AJ, Blankevoort J, Oostrik J, Koole W, de Vrieze E, Cremers C, Cremers FPM, Roosing S, Yntema HG, Kunst HPM, Zhao B, Pennings RJE, Kremer H, Consortium D (2020) A RIPOR2 in-frame deletion is a frequent and highly penetrant cause of adult-onset hearing loss. J Med Genet. PubMed

  Cunningham CL, Qiu X, Wu Z, Zhao B, Peng G, Kim YH, Lauer A, Muller U (2020) TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells. Neuron 107:126-143 e128. PubMed

• 2018

  Liu C, Luo N, Tung CY, Perrin BJ, Zhao B (2018) GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing. Cell Rep 25:1268-1280 e1264. PubMed

  Dionne G, Qiu X, Rapp M, Liang X, Zhao B, Peng G, Katsamba PS, Ahlsen G, Rubinstein R, Potter CS, Carragher B, Honig B, Muller U, Shapiro L (2018) Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture. Neuron 99:480-492 e485. PubMed

• 2017
  Cunningham CL, Wu Z, Jafari A, Zhao B, Schrode K, Harkins-Perry S, Lauer A, Müller U. “The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.” eLife. 2017 May 15;6. PMID: 28504928

  Wu Z*, Grillet N*, Zhao B, Cunningham C, Harkins-Perry S, Coste B, Ranade S, Zebarjadi N, Beurg M, Fettiplace R, Patapoutian A, Müller U. “Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.” Nat Neurosci. 2017 Jan;20(1):24-33. PMID: 27893727

• 2016
  Morgan CP*, Krey JF*, Grati M, Zhao B, Fallen S, Kannan-Sundhari A, Liu XZ, Choi D, Müller U, and Barr-Gillespie PG. “PDZD7-MYO7A complex identified in enriched stereocilia membranes.” eLife. 2016 Aug 15;5. PMID 27525485

  Zhao B*, Wu Z, Müller U. “Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.” eLife. 2016 June 8;5. PMID: 27269051

• 2015
  Zhao B*, Müller U. “The Elusive Mechanotransduction Machinery of Hair Cells: Molecules and Models.” Curr Opin Neurobiol. 2015 Oct;34:172-9. PMID: 26342686

  Beurg M*, Xiong W, Zhao B, Müller U, Fettiplace R. “Subunit determination of the conductance of hair-cell mechanotransducer channels.” Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1589-94. PMID: 25550511

• 2014
  Zhao B*, Wu Z, Grillet N, Yan L, Xiong W, Harkins-Perry S, Müller U. “TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.” Neuron. 2014 Dec 3;84(5):954-67. PMID: 25467981
• 2012
  Xiong W*, Grillet N, Elledge HM, Wagner TF, Zhao B, Johnson KR, Kazmierczak P, Müller U. “TMHS is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells.” Cell. 2012 Dec 7;151(6):1283-95. PMID: 23217710
• 2011
  He SQ*, Zhang ZN*, Guan JS*, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Bao L, Zhang X. “Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation.” Neuron. 2011 Jan 13;69(1):120-31. PMID: 21220103

  Zhao B*, Wang HB*, Lu YJ, Hu JW, Bao L, Zhang X. “Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles.” Cell Res. 2011 May;21(5):741-53. PMID: 21321602

• 2010
  Wang HB*, Zhao B*, Zhong YQ*, Li KC, Li ZY, Wang Q, Lu YJ, Zhang ZN, He SQ, Zheng HC, Wu SX, Hökfelt TG, Bao L, Zhang X.  “Co-expression of delta- and mu-opioid receptors in nociceptive sensory neurons.” Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13117-22. PMID: 20615975