Stroke is the leading cause of death and disability in U.S. Transient cerebral ischemia results in selective neuronal damage in the brain. A-type potassium current (IA) plays important role in maintaining neuronal excitability. The Xu’s lab demonstrated that enhancement of IA protects neurons against ischemia. The lab is investigating the PKC regulation of IA channels after ischemia using animal models of transient global ischemia and oxygen-glucose deprivation models of neuronal culture. Diabetes exacerbates the ischemia outcome and increases the incidence of post-ischemia seizure/epilepsy. Xu’s lab also reveal the mechanisms of epilepsy after ischemia in normoglycemic and diabetes conditions.