John Lab

The lab of Chandy John, MD focus of research is on malaria, one of the leading causes of death and long-term morbidity in children under five years of age worldwide. Studies focus on malaria pathogenesis, immunology and epidemiology; the relationships between infection, nutrition and neurodevelopment; and infections in children with sickle cell anemia. Dr. John conducts studies in medical research facilities at Indiana University School of Medicine in the United States as well as at Makerere University in Uganda and the Kenya Medical Research Institute in Kenya.

Active Research

Award Number: R01 NS055349
Funding Agency: NINDS
PI: Chandy John; Co-investigator: Andrea Conroy
Dates: 04/15/08 – 12/31/18
Sites: Kampala and Jinja, Uganda
Goal: This study seeks to establish the areas, frequency and severity of cognitive, neurologic and behavioral function affected by the 5 major forms of severe malaria in children 6 months to 4 years of age and to identify the immunological/inflammatory, metabolic and genetic factors associated with cognitive, neurologic and behavioral impairment in children with severe malaria.

Award Number: ES529474
Funding Agency: Research Agency of Norway
PI: Kamija Phiri; Co-investigator: Chandy John
Dates: 09/01/14 – 09/01/19
Sites: Malawi, Uganda and Kenya
Goal: The major goal of this project is to determine if malaria chemoprevention for a 3-month period decreases rates of readmission and death in children with severe anemia.

PI: Chandy John
Funding Agency: RWC
Dates: 01/01/15 – 12/31/20
Sites: Kisumu and North Nandi County, Kenya
Goal: The goal is this study is to understand how changes in malaria transmission, and particularly a sharp decrease in malaria transmission, affects immune responses to malaria, and to assess whether a decrease in specific responses may lead to increased future susceptibility to malaria.

Award Number: DDICRA 2013139
Funding Agency: Doris Duke Charitable Foundation
PI: Chandy John
Dates: 09/01/13 – 08/31/16
Site: Kampala, Uganda
Goal: This study is a randomized controlled trial assessing the effects of hydroxyurea therapy vs. placebo on incidence of malaria in Ugandan children with sickle cell disease.

Award Number: DDCF 2015053
Funding Agency: Doris Duke Charitable Foundation
PI: Chandy John
Dates: 06/01/15 – 11/30/16
Site: Kampala, Uganda
Goal: This award supports research mentorship of a medical student to study the frequency of iron deficiency in sickle cell anemia and its relationship to anemia and infection.

Award Number: D43 NS078280
PI: Chandy John
Funding Agency: NINDS/Fogarty International Center
Dates: 08/01/11 – 07/31/16
Site: Kampala, Uganda
Goal: This grant provides doctoral level training for students in neuropsychology, immunology, biostatistics, and epidemiology, Masters in Medicine training for pediatric and internal medicine residency, and training in mentorship for faculty members at Makerere University.

Recent Publications

Dr. John’s publications and research information are available at Google Scholar and Research Grants and Publications

Research Team

Chandy C. John, MD,  MS

Chandy C. John, MD, MS

Ryan White Professor of Pediatrics
Dibyadyuti Datta, MS,  PhD

Dibyadyuti Datta, MS, PhD

Assistant Research Professor of Pediatrics
Andrea Conroy, PhD

Andrea Conroy, PhD

Assistant Research Professor of Pediatrics

Additional Research Team Members

Research team members at the IU School of Medicine–Indianapolis campus include Lindsey Turnbull (Post-Doctoral Fellow in Pediatrics), Katrina Co (Lab Manager), Travis Putzke (Research Technician), Adnan Gopinadhan (Doctoral Student), Annie Covington, Clint Haines and Deepali Subramaniam (Undergraduate Students). The John Lab also has labs and lab team members in Uganda and Kenya.