The research lab of Mircea Ivan MD, PhD is studying the metabolic branches of the hypoxic response and how they can be exploited for synergistic anticancer combinations in solid tumors (with emphasis on brain cancer).
The laboratory is performing therapeutic targeting of brain cancer metabolism using combinations of specific metabolic inhibitors and antiangiogenic agents. The overall goal is to better understand an exploit the vulnerabilities generated by the tumor microenvironment.
The Ivan Lab is also dissecting the role of specific noncoding RNAs generated by the miR210HG and miR193BHG loci as feedback modifiers of the hypoxic response.