Molecular Mechanisms of Neural Crest-Related Congenital Heart Defects
Goals: To examine how Pax3 transcription factor regulates cardiac neural crest morphogenesis and determine the underlying mechanism of in utero heart failure in Pax3 nulls using systemic null, hypomorphic and lineage-restricted conditional mouse mutant models.
Mechanisms of adult cardiac and pulmonary fibrosis in relation to TGFβ signaling and miR-145 function.
Goals: Test whether microRNA miR145 regulates adult heart and lung fibrosis via regulation of downstream Periostin matricellular protein.
Mechanisms associated with systemic effects of cancer.
Goals: Test hypothesis that cancer-derived cytokine TNFα contributes to impairment of cardiac and muscle functions in part by suppressing systemic levels of miR-486.
Kong P, Shinde AV, Su Y, Russo I, Chen B, Saxena A, Conway SJ, Graff JM, Frangogiannis NG. (2018). Opposing Actions of Fibroblast and Cardiomyocyte Smad3 Signaling in the Infarcted Myocardium. Circulation. 137:707-724. PMID:29229611
Alvarez M, Xu L, Himes E, Chitteti B, Childress P, Mohamad S, Olivos D, Cheng Y-H, Conway SJ, Srour EF, Kacena MA. (2018). Megakaryocyte and osteoblast interactions modulate bone mass and hematopoiesis. Stem Cells Dev. doi: 10.1089/scd.2017.0178. PMID:29631496
Duchamp de Lageneste O, Julien A, Abou-Khalil R, Frangi G, Carvalho C, Cagnard N, Cordier C, Conway SJ, Colnot C. (2018). Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nat Commun. 9:773. doi: 10.1038/s41467-018-03124-z. PMID:29472541
Schwanekamp JA, Lorts A, Sargent M, York AJ, Gokey J, Whitsett JA, Conway SJ and Molkentin JD. (2017). TGFBI functions similar to Periostin but is uniquely dispensable during cardiac injury. PLOS One, 12:e0181945. PMID:28750100
Poulsen ET, Runager K, Nielsen N, Thomsen K, Snider P, Simmons O, Vorum H, Conway SJ* and Enghild JL*. (2017). Proteomic profiling of Tgfbi-null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies. FEBS, 285:101-114 [* joint corresponding authors]. PMID:29117645
Ahlfeld SK, Wang J, Gao Y, Snider P, Conway SJ. (2016). Initial suppression of TGFβ signaling and loss of TGFBI causes early alveolar structural defects resulting in bronchopulmonary dysplasia. Am J Pathol. 186:777-93. PMID:26878215
Zhou HM and Conway SJ. (2016). Restricted Pax3 deletion in the neural tube results in congenital hydrocephalus. J. Dev. Biol. 4(1), 7; doi:10.3390/jdb4010007. PMCID:PMC4777317
Simmons O, Snider P, Wang J, Schwartz RJ, Chen YP and Conway SJ. (2015). Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality. Dev. Dyn. 244:457-67. PMID:25428115
Lajiness JD, Snider P, Wang P, Feng GS, Krenz M and Conway SJ. (2014). Shp2 deletion in post-migratory neural crest cells results in impaired cardiac sympathetic innervation. Proc Natl Acad Sci USA., 111:E1374-82. PMID:2470681