Burr Lab

The primary area of research for the Burr Lab team is to evaluate the effects of pharmacologic agents used to treat osteoporosis on properties associated with quality of the bone matrix, specifically, the accumulation and repair of microdamage, changes in mineralization and alterations to the collagenous matrix.

Led by David Burr, MD, the Burr Lab has investigated matrix effects of bisphosphonates and other anti-remodeling agents for many years using canine models. In the past several years, the lab has begun to investigate changes in matrix in Type 2 diabetes using similar approaches in the ZDSD and ZDF rat models of diabetes. The laboratory is equipped to characterize histological and dynamic histomorphometric features of different tissues, and to utilize bone density (BMD) and imaging techniques (µCT, pQCT) to analyze tissues in animal models.

Active Research

IPREP: IUPUI Graduate Preparation for the Biomedical and Behavioral Sciences

This initiative is intended to prepare under-represented minority students and students with disabilities for doctoral level work in graduate school. National Institutes of Health. (NIGMS), PI: David B. Burr, 03/01/2014 – 12/31/2017

Comprehensive Training Program in Musculoskeletal Research

This program is designed to administer an effective, cross-disciplinary training environment to optimally prepare junior scientists, physicians and engineers for careers in bone biology and disease research. National Institutes of Health (NIAMS), PI: David B. Burr, 07/01/2015 – 06/30/2020

Berries and Bone

The Berries and Bone study is investigating the role that various extracts of blueberries may play in reducing inflammation and stimulating bone formation in estrogen-deficiency osteoporosis. National Institutes of Health (NCCAM), Co-I (PI: Connie Weaver), 09/01/2014 – 08/31/2019

David B. Burr, PhD

David B. Burr, PhD

Associate Vice Chancellor for Research, IUPUI
Keith W. Condon, PhD

Keith W. Condon, PhD

Adjunct Lecturer in Anatomy & Cell Biology