Allen Lab

The laboratory led by Matthew R. Allen, PhD studies the tissue-level mechanisms responsible for musculoskeletal integrity in health and disease by utilizing numerous in vivo model systems that help investigators understand how disease and pharmaceutical intervention influence bone structure, cellular activity, tissue-level properties (such as mineralization, microdamage, collagen, hydration), and biomechanical properties.

The laboratory studies a range of diseases/conditions, including osteoporosis, chronic kidney disease, and disuse using techniques that include imaging (CT, DXA, X-ray), histology (static and dynamic histomorphometry, microdamage), and mechanical testing (bending, compression, fatigue loading).

Active Research

NIH R01 – AR 062002 (Matthew Allen), Enhancing bone strength using combination drug therapy.
VA Merit grant – BX003025 (Matthew R. Allen), Treating bone deterioration associated with chronic kidney disease
NIH R01 DK110871 (Multi PI – Matthew R. Allen, Sharon Moe, Tom Nickolas), Pathogenesis of compromised bone quality and mechanics in chronic kidney disease.
NIH – F30 DK100093 (Chris Newman; Mentors: Matthew R. Allen & Sharon Moe), Assessing and modifying bone quality in chronic kidney disease
NIH R01AR064244 (Todd Bredbenner), The role of bone trait covariation in vertebral fracture resistance.
NIH – F32 DK108554 (Erin McNerny; Mentors: Matthew R. Allen & Sharon Moe), Assessing and improving bone quality in chronic kidney disease
NSF – EAGER (Co-PI – Matthew R. Allen and Thomas Siegmund), Mechanical size effects and bone failure

Led by Matthew R. Allen, PhD, Principle Investigator, this lab includes Erin McNerny, PhD, Post-doctoral Fellow; Mohammad Aref, MD/PhD student; and Elizabeth Swallow, PhD student. Other research team members include Drew Brown (Research Analyst/Lab Coordinator).