The role of skin-derived TSLP in promoting asthma development in infants with atopic dermatitis
Alternative splicing and Treg function
The Zhou Lab recently discovered that FOXP3, the master transcription factor for Treg development and function, interacts with splicing factors to regulate alternative splicing in Tregs. The research team is studying alternative splicing of human FOXP3 and mouse FOXP3 genes to investigate how the alternative splicing of human FOXP3 contributes to pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE), Type 1 diabetes and chronic asthma.
Current Research Funding
Yao, W., Zhang, Y., Jabeen, R., Nguyen, E.T., Wilkes, D.S., Tepper, R.S., Kaplan, M.H. and Zhou, B. (2013) IL-9 is Required for TSLP-mediated Allergic Airway Inflammation. Immunity. 38:360-372.
Wang, Q., Du, J., Zhu, J. , Yang, X. and Zhou, B. (2015) Thymic stromal lymphopoietin signaling in CD4+ T cells is required for TH2 memory. J. Allergy Clin. Immunol. 135: 781-791.
Sehra, S., Yao, W., Nguyen, E.T., Glosson-Byers, N.L., Akhtar, N., Zhou, B., and Kaplan, M.H. (2015). Th9 cells are required for tissue mast cell accumulation during allergic inflammation. J Allergy Clin Immunol. 136:433-440.
Zeng, W.P., McFarland, M.M., Zhou, B., Holtfreter, S., Flesher, S., Cheung, A., and Mallick, A. (2017) Staphylococcal enterotoxin A-activated regulatory T cells promote allergen-specific TH2 response to intratracheal allergen inoculation. J Allergy Clin Immunol. 139:508-518.
Du, J., Wang, Q., Ziegler, S.F., and Zhou, B. (2018) FOXP3 interacts with hnRNP F to modulate pre-mRNA alternative splicing. J. Biol. Chem. 293:10235-10244.
Additional Research Team Members
Additional research team members include Lina Wang (research technician) and Shuangshuang Yang (graduate student).