The research lab of Yu-Chien Wu, MD, PhD, is actively investigating a wide range of radiology and imaging topics. Wu is particularly focused on studying diffusion physics in biologic system using diffusion MRI.
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Alzheimer's disease
Animal Imaging
Concussion
Imaging
The lab highlights the growing impact of computational methods, combined imaging techniques, and animal models in advancing neuroscience research.
TBI
The lab addresses the sensitivity issues of conventional medical imaging techniques in detecting mild traumatic brain injury (mTBI) by utilizing hybrid diffusion imaging (HYDI).
Research Collaborations
Research collaborations are pivotal in advancing research within the Wu Lab. These partnerships help foster synergy, pooling diverse expertise and resources to tackle complex challenges. From access to specialized equipment, funding, and data, to amplifying research capabilities—shared knowledge accelerates innovation, refining diagnostic techniques and potential treatment strategies.Ultimately, partnerships amplify a lab's impact, driving transformative progress in neuroscience.
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Active Collaborations
Alzheimer’s Disease
R01 AG053993-01, NIA, Wu (PI), 2016 – 2021
Modeling Axonal Density and Inflammation-Associated Cellularity in Alzheimer’s Disease Using Hybrid Diffusion Imaging -
Previous Collaborations
Alzheimer’s Disease
R01 AG053993-01, NIA, Wu (PI), 2016 – 2021
Modeling Axonal Density and Inflammation-Associated Cellularity in Alzheimer’s Disease Using Hybrid Diffusion Imaging
Cirrhosis
Clinical Trial, Intercept Pharmaceuticals, Chalasani (PI), 2015 – 2017
Dissection of Cholestatic Itch in Primary Biliary Cirrhosis
Concussion
W81XWH-14-2-0151, The NCAA-DoD Grand Alliance, McAllister (PI), 2014 – 2017
Concussion Assessment, Research and Education Consortium (CARE)
Hypoxic-Ischemic Injury
RadPDT, IU Radiology Project Development Team, Kralik (PI), 2017 – 2018
Evaluation of Resting State fMRI in Neonates with Hypoxic-Ischemic Injury
Imaging
(Completed) Pilot Project, Indiana Alzheimer Disease Center, Wu (PI), 2014 – 2015
Measuring Axonal Diameters and Density with a Novel ActiveAx and Fast RSA-EPI Sequence
(Completed) MITRA, Dartmouth Synergy, Wu and Holtzheimer (PI), 2012 – 2015
High Angular Resolution Diffusion Imaging (HARDI) with novel HYPR image reconstruction
(Completed) Research Project, IUPUI/RITDP, Wu (PI), 2015 – 2016
Hybrid Diffusion Imaging (HYDI) of the Kidney
TBI
CTR, CTSI, Wu (PI), 2016 – 2018
Microstructure Modulated White Matter Connectivity for Mild Traumatic Brain Injury
Indiana Spinal Cord and Traumatic Brain Injury Research Fund, Massie (PI), 2017 – 2019
Improving functional ability in chronic TBI with intensive rehabilitation robotic gait training.
(Completed) R21 NS075791-01, NINDS, Wu and McAllister (PI), 2011 – 2015
HYBRID Diffusion Imaging to Detect Acute White Matter Injury After Mild TBI
(Completed) Research Project, IUPUI/ITDP, Wu (PI), 2015 – 2016
Microstructure Imaging of the Human Brain with TBI
The Wu Lab is a national leader in neuroscience expertise. From working on studies like the CARE Consortium, the world's most comprehensive concussion study, to uncovering early diagnosis treatments for Alzheimer's disease—the Wu Lab is a pioneering hub for research excellence at IU School of Medicine and across the country.
Previous Lab Research
RoSA, Rotating Single Shot Acquisition, is a novel diffusion sequence developed in this lab for high-quality and high-resolution diffusion imaging. It can achieve spatial resolution of 1x1x1 mm3 at imaging acquisition for diffusion while maintaining high signal-to-noise ratio and minimal image distortion.
White Matter Tractography
In the Wu Lab, whole brain white matter tractography is performed using either CAMINO or MRTrix3 open source software. Hybrid Diffusion Imaging technique is used to acquire high angular resolution samples at high b-value diffusion weighting. Crossing fibers are resolved using q-ball reconstruction for fiber orientation distribution function (ODF).
Super resolution track density map
From tractography, investigators in this lab are able to produce submillimeter super resolution map of tack density using MRTrix3 software.