Current Research Funding
07/15/12 – 05/31/22
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function
Goals: to determine whether extra daily vitamin C taken by pregnant women who cannot quit smoking, can block the negative effects of the smoking on the infant’s lung function and respiratory symptoms.
Maternal Vitamin C Supplementation to decrease effects of smoking during pregnancy on infant lung function and health
Goals: Our cohort of infants of mothers who could not quit smoking during pregnancy and received extra daily vitamin C or Placebo are part of the national multi-center NIH cohorts participating in Environmental influences on Child Health Outcomes (ECHO).
09/15/15 – 05/31/19
Anti-Angiogenic Preeclamptic Milieu Impairs Infant Lung and Vascular Development
Goals: 1) Determine whether angiogenic circulating progenitor cells (CPCs) in cord blood are associated with the risk of premature infants developing chronic lung disease of infancy (CLDI) and whether post-natal CPCs and environment alters the relationship between cord blood CPCs and CLDI, and 2) Determine whether angiogenic CPCs in cord blood are associated with pulmonary pathophysiology at 6 months corrected-age and whether post-natal CPCs and environment alters the relationship between cord blood CPCs and pulmonary dysfunction.
7/01/15 – 6/30/20
CPAP Drives Lung Growth and Pulmonary Function in Moderately Preterm Primates
Goals: 1) Determine whether applying CPAP for 10 days stimulates lung growth, improves lung function, and suppresses airway reactivity in non-human moderately premature primates and whether these effects persist with subsequent lung growth and development, and 2) Identify pathways and mechanisms by which CPAP stimulates lung growth and improves lung function.
09/01/2018 – 08/31/2019
Physiological Phenotyping of Respiratory Outcomes in Infants Born Premature
Studies proposed are highly innovative, testing new ideas that challenge current paradigms regarding BPD definition and outcomes by demonstrating the potential role for more precise phenotyping based on novel measures relating specific pulmonary pathophysiology and proteomic patterns with late respiratory outcomes to better distinguish infants at risk for sustained respiratory disease during early childhood.
3/01/2017 – 8/30/2018
Hypoxia-dependent Epigenetic Modifications in the Pulmonary Vasculature
Goals: determine if in utero hypoxia results in epigenetic modifications in hypoxia-sensitive pathways in the lung vasculature that begin in utero and that persist until adulthood; determine if epigenetic modifications in utero are reversible and inducible when the post-utero environment is changed.
Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health. McEvoy CT, Milner KF, Scherman AJ, Schilling DG, Tiller CJ, Vuylsteke B, Shorey Kendrick LE, Spindel ER, Schuff R, Mitchell J, Peters D, Metz J, Haas D, Jackson K, Tepper RS, Morris CD. Contemporary clinical trials. 2017; 58:66-77.
Cumulative effects of neonatal hyperoxia on murine alveolar structure and function. Cox AM, Gao Y, Perl AT, Tepper RS, Ahlfeld SK. Pediatric Pulmonology. 2017; 52(5):616-624.
Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses. Cheon IS, Son YM, Jiang L, Goplen NP, Kaplan MH, Limper AH, Kita H, Paczesny S, Prakash YS, Tepper R, Ahlfeld SK, Sun J. J Allergy Clin Immunol. 2017 Dec 15. S0091-6749(17)32871-3.
Chronic Hypoxia Accentuates Dysanaptic Lung Growth. Llapur CJ, Martínez MR, Grassino PT, Stok A, Altieri HH, Bonilla F, Caram MM, Krowchuk NM, Kirby M, Coxson HO, Tepper RS. American Journal of Respiratory and Critical Care Medicine. 2016; 194(3):327-32.
Increased Cardiac Output and Preserved Gas Exchange Despite Decreased Alveolar Surface Area in Rats Exposed to Neonatal Hyperoxia and Adult Hypoxia. Goss KN, Tepper RS, Lahm T, Ahlfeld SK. American Journal of Respiratory and Critical Care Medicine. 2015; 53(6):902-6.
Research team members within the Wells Center include research technicians Amy Gao and Fredrick Herman. Additional research team members from the Riley Infant Pulmonary Function Laboratory include Christina Tiller, Michelle Cunningham and Jeffrey Bjerregaard.