Genetic defects in a several genes, some known for decades and others discovered more recently, can lead to abnormalities in glycogen structure and/or accumulation. Usually, there is an over-accumulation of glycogen. Investigators in this lab are interested mainly in three of these glycogen storage diseases: Pompe Disease (GSD II), Cori Disease (GSD III) and Lafora disease. The Roach Lab has shown that genetic depletion of glycogen accumulation in mouse models of glycogenoses can correct pathological consequences of the aberrant glycogen storage. These results suggest a possible therapeutic approach to treat glycogenoses: suppress glycogen accumulation in tissues.