June 1, 2018—May 31,2020
“Cellular RNA binding and regulation by NFX1-123 and its perturbation by high-risk human papillomavirus E6”
The goals of this project are to investigate the hijacking of a host cell RNA binding protein by HPV E6 to drive dysregulation in HPV infections and cancer development.
September 1, 2016—August 31, 2021
“HIV integration-mediated modulation of immune regulation in HPV-associated cancers”
The major goals of this project are to determine whether HIV infection drives a novel mechanism for HPV-associated cancer development and progression.
June 4, 2014—May 31, 2019
“HPV E6 and NFX1-123 in differentiation, cell regulation and cancer”
The major goals of this project are to understand the collaborative role of NFX1-123 and HPV E6 in gene regulation, in epithelial architecture, and in cancer development and progression.
PA Vliet-Gregg, JR Hamilton and RA Katzenellenbogen. NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes. J Virol 2013;87(24):13741-13750. PMID24109236. PMC3838236.
M Xu, RA Katzenellenbogen, C Grandori and DA Galloway. An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes. Virology 2013;446(1-2):17-24. PMID24074563. PMC3787310.
RA Katzenellenbogen, JJ Carter, JE Stern, MS Butsch Kovacic, PA Mehta, SL Sauter, DA Galloway and RL Winer. Skin and mucosal human papillomavirus seroprevalence in persons with Fanconi Anemia. Clin Vaccine Immunol 2015;22(4):413-420. PMID25651924. PMC4375352.
PA Vliet-Gregg, JR Hamilton and RA Katzenellenbogen. Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest. Virology 2015;478:50-60. PMID25723053. PMC4383269.
RL Winer, CE Huang, S Cherne, JE Stern, MS Butsch Kovacic, PA Mehta, SL Sauter, DA Galloway and RA Katzenellenbogen. Detection of human papillomavirus in the oral cavities of persons with Fanconi anemia. Oral Dis 2015;21(3):349-354. PMID25158861. PMC4344428.
J Levan, P Vliet-Gregg, K Robinson, and RA Katzenellenbogen. Human papillomavirus type 16 E6 and NFX1-123 mislocalize immune signaling proteins and downregulate immune gene expression in keratinocytes. PLoS One 2017; 12(11):e0187514. PMID29117186. PMC5695606.
Additional Research Team Members
Additional research team members in the Katzenellenbogen Lab are Patty Gonzalez-DeWhitt, research analyst and laboratory manager, and Kevin Quist, research technician.