Diabetes and Obesity
Alcoholic and Non-alcoholic Fatty Liver Diseases
Current Research Funding
NIH R01 DK091592 (PI), 3/1/12-2/28/18, 3.6 calendar
Goal: This project is to illustrate the molecular regulation of hepatic lipid metabolism
NIH R01DK107682 (MPI/Liangpunsakul & Dong), 7/1/16 – 6/30/20, 2.4 calendar
Goal: To illustrate the molecular mechanisms underlying the Sestrin3 function in the development of fatty liver disease.
NIH R21AA024550-01A1 (PI), 3/1/17 – 2/28/19, 2.4 calendar
Goal: To explore the hepatic protective function of sirtuin 6 against alcohol-induced tissue damage.
Showalter Scholar Award (PI, 07/01/15 – 06/30/18, .60 calendar
Agency: IUSM & Showalter Trust Funds
Goal: To enhance faculty research and career development.
Indiana CTSI CTR, (MPI/Liu, Dong, Yeo), 07/01/16 – 6/30/18, .60 calendar
Agency: Indiana CTSI
Goal: To develop a collaborative team for the NASH translational research.
IUPUI RSFG-DONG (PI) , 6/1/17-6/30/18, .60 calendar
Goal: This pilot grant aims to support the generation of additional preliminary data for an external grant application.
Indiana CTSI CTR (MPI/Liangpunsakul, Dong, Zhang C, and Zhang M), 10/1/17 – 9/30/19, .60 calendar
Agency: Indiana CTSI
Goal: This pilot study is to identify molecular profiles from alcohol heavy drinkers.
Indiana State Department of Health, Xu (PI), 7/1/17-6/30/19, .60 calendar
Agency: Indiana State Department of Health
Goal: This project is to illustrate the mechanism of Sestrin 3 in the protection against post-traumatic epilepsy.
A complete list of published work is available.
- Dong XC. SCP4, a small nuclear phosphatase having a big effect on FoxOs in gluconeogenesis. Diabetes. 2017 (in press).
- Xiong X, Zhang C, Zhang Y, Fan R, Qian X, Dong XC. Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice. J Endocrinol. 2017 Apr 6. pii: JOE-17-0033.
- Pan X, Zhang Y, Kim HG, Liangpunsakul S, Dong XC. FOXO transcription factors protect against the diet-induced fatty liver disease. Sci Rep. 2017 Mar 16; 7:44597.
- Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, Ding WX, Tong, X, Tersey SA, Harris RA, Mirmira RG, Evans-Molina C, Dong XC. Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Diabetologia 2016 Jan;59(1):151-60.
- Tao R, Xiong X, Liangpunsakul S, Dong XC. Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Diabetes 2015 Apr; 64(4): 1211-23.
Additional Research Team Members
Other faculty lab team members include Yunjian Liu, MD; Ping Xu, PhD; Yang Zhang, PhD; and Xiaolin Zhong, MD.