Apostolova Lab

The Apostolova lab, led by Liana G. Apostolova, MD, focuses on the characterization of early symptomatic and pre-symptomatic stages of Alzheimer’s disease and on the development and validation of sensitive imaging and genetic biomarkers for Alzheimer’s disease and other dementing disorders. The lab is affiliated with the Indiana Alzheimer Disease Center, the Center for Neuroimaging and several other school centers and departments. The lab works with data from several high profile Alzheimer’s disease studies, including data from the Longitudinal Early Onset Alzheimer’s Disease Study (LEADS) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The lab also works with datasets from the Imaging and Genetic Biomarkers for Alzheimer’s Disease Study (ImaGene).

Active Research Projects

Longitudinal Early Onset Alzheimer’s Disease Study (LEADS)

Apostolova and her co-PIs Maria Carrillo, PhD, Brad Dickerson, MD, and Gil Rabinovici, MD, received a total of $52.3 million to conduct a national multi-institutional study on early-onset Alzheimer’s disease. The study will comprehensively evaluate 400 participants diagnosed with early-onset Alzheimer’s disease, characterized by an age of onset before 65 years, and 100 age-matched cognitively intact controlled participants. The study collects detailed clinical, cognitive, imaging (MRI, amyloid and tau PET), fluid biomarker (peripheral blood, cerebrospinal fluid) and genetic (DNA, RNA) data.

Imaging-Genetics Biomarkers for Alzheimer’s Disease (ImaGene)

Led by Apostolova, this study uses advanced statistics, machine learning and network science approaches on comprehensive, multimodal data acquired from subjects in pre-symptomatic and early-symptomatic stages of disease. These techniques are crucial in order to identify promising imaging and genetic biomarkers that can accurately assess an individual’s risk for developing Alzheimer’s disease and discover new critical disease-related pathways. Improved understanding of the molecular and genetic triggers of Alzheimer’s disease will bring research closer to genomic-based interventions and personalized risk assessment.

Current Research Funding

NIA R56 AG057195/ U01 AG057195 (09/15/2017-08/31/2022)

PIs: Liana Apostolova, MD, Maria Carrillo, PhD, Brad Dickerson, MD, and Gil Ravinovici, MD.
Apostolova leads the administrative and clinical cores of the study at the IU School of Medicine clinical site.

This project is recruiting and following 400 people with early-onset Alzheimer’s disease across 15 clinical sites in the US. The study will collect detailed cognitive, clinical, imaging (MRI, amyloid and tau PET) and fluid biomarkers (DNA, RNA, plasma, serum, PBMC, CSF) from participants in order to better understand pathophysiology and design new treatment trials for this segment of the Alzheimer’s population.

NIA R01AG057739 (09/01/2018-08/31/2023)

PIs: Brea Perry, PhD, Liana Apostolova, MD, and Andrew J. Saykin, PsyD

This research examines social and biological mechanisms underlying relationships between personal social networks and patterns of neurodegeneration in preclinical and early stages of Alzheimer’s disease using neuroimaging biomarkers.

NIA P30AG010133

PI: Andrew Saykin, PsyD
Clinical Core Leader: Liana G. Apostolova, MD

The Clinical Core of the Indiana Alzheimer Disease Center (IADC) recruits and longitudinally follows a diverse cohort of subjects to collect standardized clinical, neuropsychological and biomarker data to support innovative interdisciplinary research locally, nationally and internationally. The Clinical Core supports the overall mission of the IADC to improve early detection of neurodegenerative diseases at the transition from normal cognition to prodromal stages by providing researchers with high quality clinical, imaging, biomarker and neuropathological data in Alzheimer’s disease and hereditary dementias.

NIA F32AG062157 (09/01/2018-08/31/2021)

PI: Diana Svaldi, PhD
Sponsor: Liana G. Apostolova, MD
Co-sponsors: Andrew Saykin, PsyD, and Joaquin Goni Cortes

This study is developing connectivity biomarkers to assess the progression of Alzheimer’s disease and to develop connectivity-based biomarkers for early detection of Alzheimer’s disease.

Research Team

Apostolova
Liana G. Apostolova, MD

Liana G. Apostolova, MD

Barbara and Peer Baekgaard Professor of Alzheimer's Disease Research
David G. Clark, MD

David G. Clark, MD

Associate Professor of Clinical Neurology
Diana O. Svaldi, PhD

Diana O. Svaldi, PhD

Postdoctoral Fellow in Neurology

Additional Research Members

Gena Antonopoulos BSN, RN, clinical research nurse manager
Lora Dean, administrative assistant
Jenna Groh, research coordinator
Allison Rainford, research coordinator
Apoorva Sanjay, PhD student
Eddie Stage, PhD student
Heather Wagoner, grant manager

Past Members

Tugce Duran, research technician
Meredith Phillips, research coordinator