YOU ARE EXPLORING

Clinical Trials

The Departments of Neurology and Psychiatry at Indiana University School of Medicine continue to be leaders in preclinical and clinical research and discovery. Faculty and staff investigators conduct innovative research in a wide array of areas and are supported by federal grants from the National Institute of Neurological Disorders and Stroke; Alcohol Abuse and Alcoholism, and Aging; and the National Science Foundation.

The lab of David Kareken, PhD, professor of neurology, involves neuroimaging of the human brain’s reward system (using positron emission tomography and functional magnetic resonance imaging) and motivated behavior for natural rewards, like food, along with drugs of abuse. Lab work is targeted to understand the brain and genetic vulnerabilities that may predispose individuals to disorders such as alcoholism and obesity. Research is funded by the National Institute of Alcohol Abuse and Alcoholism.

The lab Brandon Oberlin, PhD, assistant professor of psychiatry, focuses on unhealthy decision-making, behavioral traits linked to addiction/alcoholism disorders, and brain activation governing those behaviors. Dr. Oberlin’s lab utilizes neuroimaging (fMRI) to better understand brain systems underlying addiction, laboratory behavioral tasks to measure behavior, and digital visualization methods for relapse prevention.

Current Clinical Trials

fMRI of Chemical Sense Stimulation in Substance Use Disorders (Participants ages 21 – 26)

This study takes place over the course of two days. On the first day, participants receive an MRI while also being given small doses of sugar water. On the second day, participants administer alcohol to themselves intravenously at a desired level that is most enjoyable for them. This study and prerequisite screening interview takes place at Goodman Hall and/or IU Health University Hospital in Indianapolis, and is conducted Monday through Friday. Participants of this study will receive up to $325 with additional opportunities for payment throughout the study visit.

Imaging of Alcohol and Reward Seeking Behavior (Participants ages 21 – 30)

This overnight study involves participants receiving and MRI scan and a PET scan, as well as an infusion of alcohol. Participants administer alcohol to themselves intravenously at a desired level that is most enjoyable for them. The study takes place at Goodman Hall and IU Health University Hospital in Indianapolis, and is conducted primarily on Tuesdays, Wednesdays and Thursdays. Participants of this study will receive up to $400 compensation for their time, with opportunities for additional payment throughout the study visit.

Neural Bases of Alcohol-Related Decision-Making (Participants ages 21-45)

This one-day study involves participants receiving a short alcohol infusion and completing tasks during an MRI scan. The study takes place at the Stark Neurosciences Research Institute (Goodman Hall) in Indianapolis. This study are conducted Monday through Friday during business hours. Participants of this study will receive $200 with the possibility of earning more throughout the visit.

Clinical Trials Support

The Office of Clinical Research serves as the single point of entry for clinical trials across Indiana University and provides streamlined support for IU School of Medicine faculty investigators in the facilitation of research studies including contracting, budgeting and metric tracking.