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Precision Medicine

The precision medicine team is focused on genetic musculoskeletal diseases, such as X-linked hypophosphatemia, autosomal dominant hypophosphatemia, and genomic, metabolomics, protemic determinants of bone density, osteoporosis and sarcopenia in aging and chronic disease. These investigators focusing on the causes of these diseases, and working to develop treatments and cures.

Grants

“Changes in phosphate metabolism cause pathologic cardiac remodeling in chronic kidney disease (CKD)”
Award period: 2/1/19 to 1/31/23
PI: K. White

Therapeutic potential of HIF-PHDi in the control of bioactive FGF23 in CKD
Active dates: 7/2019-6/2022
PI M. Noonan, IBMG/PhD student in White lab
*priority score of 20.

Bone quality and strength across life-stages in glomerular disorders
Co-I M. Allen

The effect of etelcalcetide on bone-tissue properties and calcification propensity in end stage kidney disease

Co-PI M. Allen

NHGRI U01

A clinical trial will be moving forward this summer/fall of a prospective testing of pharmacogenetic guided opioid therapy for acute pain, including patients such as those receiving hip and knee replacements

Multi-PI: T. Skaar

NIGMS

An R35 MIRA grant has been funded from NIGMS focused on the molecular mechanisms that regulate hepatic drug metabolism and contribute to interindividual variability in drug efficacy and toxicity

PI: T. Skaar

P01 development in FGF23/Klotho-related mineral metabolism

PI: M. Allen, S. Moe, M. Econs, K. White

Team Leaders

Todd C. Skaar, PhD

Todd C. Skaar, PhD

Professor of Medicine
Kenneth E. White, PhD

Kenneth E. White, PhD

Chancellor's Professor

Faculty Investigators

Matthew R. Allen, PhD

Matthew R. Allen, PhD

Assistant Dean for Faculty Affairs and Professional Development
Teresita M. Bellido, PhD

Teresita M. Bellido, PhD

Professor of Anatomy & Cell Biology
Angela Bruzzaniti, PhD

Angela Bruzzaniti, PhD

Associate Professor of Oral Biology, School of Dentistry
Neal X. Chen, MD, PhD

Neal X. Chen, MD, PhD

Associate Research Professor of Medicine
Michael J. Econs, MD

Michael J. Econs, MD

Distinguished Professor
Erik A. Imel, MD

Erik A. Imel, MD

Associate Professor of Medicine
Uma Sankar, PhD

Uma Sankar, PhD

Associate Professor of Anatomy & Cell Biology