Histology and Histomorphometry Core

Led by David Burr, PhD, and Lilian Plotkin, PhD, the Histology and Histomorphometry Core is currently active on the IU School of Medicine—Indianapolis campus as the Histology Lab Service Core and is currently being redesigned as it becomes a research core of the Indiana Center for Musculoskeletal Health.

The future design of the core will provide customized services to meet the needs of the musculoskeletal research community. This core will improve accessibility to, and reproducibility of, histological and histomorphometric analyses of all musculoskeletal tissues using standard (histology, immunohistochemis-try) and newer (multi-photon microscopy, tissue clearing, 3D histology) techniques developed for musculoskeletal applications. The Histology and Histomorphometry Core will foster collaborations by providing services to musculoskeletal investigators who otherwise would not have access to them and facilitate multidisciplinary research by establishing new relationships with investigators outside the field who might have need for analysis of musculoskeletal tissues.


The goals of the Histology and Histomorphetry Core are to provide bone and muscle histological phenotyping, including histological bone and muscle tissue preparation and staining, as well as histomorphometric analysis. This core will also provide consistency and comparability of measurement modalities across studies, by providing protocols and quality control standards for technical procedures and coordinated guidance to investigators and provide consultation on study design and post-study data interpretation. Finally, the Histology and Hisomorphometry core will continuously monitor improvements in methodology and instrumentation and incorporate into the histology core as they become available to provide a more comprehensive set of outcomes for the investigator and to assure that preparation of tissues and methodologies across the cores are suitable and sequenced properly to achieve the maximum information from a given study.