Center for Diabetes and Metabolic Diseases

Diabetes Translational Research Studies

The Diabetes Translational Research Program at IU School of Medicine is conducting a wide range of research studies that focus on different areas of diabetes, including primary prevention of diabetes, the treatment of depression and diabetes, the design and delivery of diabetes clinical care, provider-patient communication, medication adherence, the role of genetics on diabetes, and the development of health-promotion partnership programs with under-resourced communities.

Diabetes Prevention Program Outcomes Study

The Diabetes Translational Research Program was a study site for the Diabetes Prevention Program (DPP), which was a study of interventions to prevent development of type 2 diabetes in overweight adults with impaired glucose tolerance (IGT). The Diabetes Prevention Program Outcomes Study is a continuation of the study investigating the role of aging on health and diabetes prevention.

Primary Prevention of Type 2 Diabetes

A study comparing two implementation models for the primary prevention of type 2 diabetes in persons with increased risk. Both models assist practices to choose local approaches to identify pre diabetes and offer diabetes prevention services. Only intervention sites include a community liaison from YMCA on local practice implementation team.


Program ACTIVE II is a randomized controlled trial designed to test the effectiveness of two different forms of behavioral treatment of major depression in adults with type 2 diabetes: counseling and exercise.  Participants for the study were recruited from  Indianapolis, southeastern Ohio and West Virginia.

Program ACTIVE II has demonstrated that counseling, exercise and combined interventions have resulted in improving depression outcomes 5-6 times greater than usual care.  In addition, participants who were assigned to the combination condition of counseling and exercise had a significant improvement in A1c (1.7% reduction) from baseline to post-intervention compared to usual care.

Two secondary aims are addressed by the study: 1) To compare changes in cardiovascular risk factors, exercise capacity, blood lipid profiles, resting blood pressure across intervention groups at post-intervention, 6- and 12-month follow-up assessments compared to usual care and; 2) To assess the comparative cost-effectiveness of each intervention arm against usual care in terms of predicted incidence of diabetes complications (e.g. coronary heart disease) and quality of life.