Center for Diabetes and Metabolic Diseases

Center for Diabetes and Metabolic Diseases Research

Research at the Center for Diabetes and Metabolic Diseases (CDMD) is highly collaborative and focuses on four major themes that represent the breadth and depth of basic, translational and clinical research.

In support of this work, five research cores provide enhanced expertise and access to state-of-the-art methodologies, which promote high-impact scientific discoveries.

Research Themes

Cellular and Molecular Metabolism

There are 21 investigators in the Cellular and Molecular Metabolism theme who study a broad cross-section of metabolic regulation that remains a fundamental challenge in biology and a significant issue in disorders of glucose and lipid metabolism.

Complications of Diabetes and Obesity

The 31  investigators in this group focus on delineating central mechanisms underlying the complications of obesity and diabetes–such as retinal complications, wound healing, skeletal changes, and chronic kidney disease.

Islet Function and Survival

There are 21 researchers in the Islet Function and Survival theme, who form a highly interactive group of basic and translational investigators that focuses on the role of the pancreatic islet in Type 1 and Type 2 diabetes.

Nutrition and Physiology of Obesity

The Nutrition and Physiology of Obesity theme is comprised of 21 collaborative basic and translational investigators who focus on ingestive behavior, energy balance, obesity and weight loss, primarily in human subjects but also using rodent and other animal models.

Research Cores

Five research cores serve as a vital resource for rich, collaborative partnerships and state-of-the-art methodologies for innovative translational research. The center’s research program is augmented by educational and funding activities that cultivate and promote investigators to become leaders in diabetes research by linking investigators, scientific discovery and the Indianapolis community.

Islet and Physiology Core

Under the leadership of director Carmella Evans-Molina, MD, associate professor of medicine, and assistant director Sarah Tersey, PhD, associate research professor of pediatrics, the Islet and Physiology Core provides IU School of Medicine and regional investigators with the capability to obtain high-quality rodent pancreatic islets for study. This core also provides services for islet transplantation and assists investigators who wish to perform immunohistochemistry, immunofluorescence and/or analysis of beta cell mass on whole pancreata from mouse and rat models. In addition, the core offers several services for rodent metabolic characterization, including performance insulin and glucose tolerance testing, analysis of body composition and metabolic cage analysis using the TSE System cages. For more information, contact the core.

Microscopy Core

The Microscopy Core is a nationally recognized service core at IU School of Medicine that provides consultation and access to state-of-the-art microscope equipment. To better serve regional diabetes researchers, this core provides consultation and specialized services for intravital microscopy of pancreas and transplanted islets, FRET assays, and fluorescent biosensors for analysis of intracellular signaling cascades. Kenneth Dunn, PhD, associate professor of medicine, serves as the core’s director, and Richard Day, PhD serves as assistant director. Fees for investigators affiliated with the Center for Diabetes and Metabolic Diseases at IU School of Medicine are available on MedNet.

Swine Core

The Swine Core is a unique resource of IU School of Medicine and Purdue University and serves as a regional and national shared resource core of the International Development Research Centre (IRDC). Under the direction of Michael Sturek, PhD, chair of cellular and integrative physiology, this core utilizes a novel breeding colony of Ossaaw sine with metabolic syndrome and long-term complications, most notably cardiovascular disease. In addition, the core provides swine maintenance (glucose tolerance tests, body composition, glucose clamp studies and imaging studies), characterization of cardiovascular disease (intravascular ultrasound, blood flor velocity and microvascular studies) and tissues (banked and fresh) for analysis ex vivo. For more information or to request services, contact Mouhamad Alloosh, MD, assistant director for the core.

Translation Core

The Translation Core provides services that facilitate the conduct of research involving human subjects, including supplying low-cost, high-quality analyte measurement services for a variety of hormones, cytokines, lipids and other analytes. Translation Core human studies services include phenotyping (i.e. GTT, clamp studies, tracer studies), and access to a biobank of human tissues and serum. The core has the capacity to undertake specialized and customizable laboratory services, including bringing online assays not previously available at IU School of Medicine. For more information or to request services, contact Kieren Mather, MD, director of the Translation Core, or Robert Considine, PhD, associate director.

Systems and Informatics Core

New in 2019, the Systems and Informatics Core addresses the emerging need for large data acquisition and analysis. The Systems and Informatics Core provides a suite of proteomics and genomics services that will be coupled to bioinformatics. Services include global protein quantitation (untargeted), phosphoproteomics, post-translational modification analysis from purified samples, protein ID from solution, beads, or gel bands, protein-protein interaction analysis, and protein/peptide quantitation (targeted). A range of genomics services will be offered, including mRNA sequencing, single cell RNA sequencing (10X Genomics platform), ChIP-Seq/Exo, CLIP-Seq, ATAC-Seq, Ribo-Seq, genome sequencing. For more information or to request services, contact  Amber Mosley, PhD, or Yunlong Liu, PhD, co-directors of the core.
Diabetes Clinical Trials

Diabetes Clinical Trials

Center for Diabetes and Metabolic Diseases investigators conduct clinical trials focused on the prevention and treatment of Type 1 diabetes, Type 2 diabetes and obesity.