Indiana Alzheimer Disease Center

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Neuropathology Core

The Neuropathology Core carries out state-of-the-art neuropathological examinations of brain, spinal cord and other tissue samples obtained from individuals affected by neurodegenerative dementia and/or related neurodegenerative diseases. This core supports a large number of national and international scientists with frozen and fixed samples from the tissue repository.

The Neuropathology Core interacts with the Clinical Core, Neuroimaging Core and Genetics and Biomarkers Core to study patients applying concepts of precision medicine. This multidisciplinary approach helps to provide a definitive diagnosis of dementing disorders.

Alzheimer’s Disease Expertise Services

Core members offer technical resources, laboratory facilities and professional expertise for the collection, diagnosis and storage of tissue obtained at autopsy from patients with dementia and control subjects studied in the Indiana Alzheimer Disease Center Clinical Core as well as other Alzheimer disease centers, the frontotemporal dementia project of the NINDS, Dominantly Inherited Alzheimer Network and academic institutions. Core services are also available to families from the community, including those referred by the Alzheimer’s Association chapters.

The Core is also involved in continuing education to physicians, researchers, technicians and the community about new developments emerging from Alzheimer’s disease research. Results from studies carried out by investigators of the NPC are presented at numerous national and international conferences, including the annual Alzheimer’s Association International Conference.

Pathologic Data Analysis

The Neuropathology Core provides information about pathologic data to referring physicians and families as well as well-characterized tissue to basic researchers. The core has expanded the center’s mission to integrate molecular technology to assist in the neuropathologic diagnosis. By combining data obtained by neurohistology, immunohistochemistry and immunocytochemistry, the core members can recognize and characterize the localization and the antigenic profile of molecules that are important to the pathogenesis of dementia. These studies, carried out in parallel with molecular analysis, are fundamental to understanding disease etiology and phenotypic heterogeneity.