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Precision Medicine

The precision medicine team is focused on genetic musculoskeletal diseases, such as X-linked hypophosphatemia, autosomal dominant hypophosphatemia, and genomic, metabolomics, protemic determinants of bone density, osteoporosis and sarcopenia in aging and chronic disease. These investigators focusing on the causes of these diseases, and working to develop treatments and cures.


  • NIH-NHLBI R01-HL145528
    “Changes in phosphate metabolism cause pathologic cardiac remodeling in chronic kidney disease (CKD)”
    Award period: 2/1/19 to 1/31/23
    PI: K. White
    Therapeutic potential of HIF-PHDi in the control of bioactive FGF23 in CKD
    Active dates: 7/2019-6/2022
    PI M. Noonan, IBMG/PhD student in White lab
    *priority score of 20.
    Bone quality and strength across life-stages in glomerular disorders
    Co-I M. Allen
  • Amgen
    The effect of etelcalcetide on bone-tissue properties and calcification propensity in end stage kidney disease

    Co-PI M. Allen

    NHGRI U01

    A clinical trial will be moving forward this summer/fall of a prospective testing of pharmacogenetic guided opioid therapy for acute pain, including patients such as those receiving hip and knee replacements

    Multi-PI: T. Skaar


    An R35 MIRA grant has been funded from NIGMS focused on the molecular mechanisms that regulate hepatic drug metabolism and contribute to interindividual variability in drug efficacy and toxicity

    PI: T. Skaar

    P01 development in FGF23/Klotho-related mineral metabolism

    PI: M. Allen, S. Moe, M. Econs, K. White

Team Leaders

Todd C. Skaar, PhD

Professor of Medicine

Kenneth E. White, PhD

Chancellor's Professor

Faculty Investigators

Matthew R. Allen, PhD

Assistant Dean for Faculty Affairs and Professional Development

Lynda F. Bonewald, PhD

Director, Indiana Center for Musculoskeletal Health

Angela Bruzzaniti, PhD

Director of Student Research, School of Dentistry

Neal X. Chen, MD, PhD, BS

Associate Research Professor of Medicine

Erica L. Clinkenbeard, PhD

Assistant Professor of Medical and Molecular Genetics

Michael J. Econs, MD

Distinguished Professor

Clair A. Francomano, MD

Professor of Medical & Molecular Genetics

Erik A. Imel, MD

Associate Professor of Medicine

Uma Sankar, PhD

Associate Professor of Anatomy, Cell Biology & Physiology

Other Members

Patricia Celestino-Soper, PhD, DABMGG

Megan Noonan, PhD Postdoc