Alzheimer's Disease

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IU announces progress toward its Precision Health Grand Challenge: cancers it aims to cure, diseases it is working to prevent

Today Indiana University researchers and physicians announced progress toward their bold goals of developing cures and preventive treatments for devastating diseases prevalent among Indiana residents.IU Precision Health leaders announced they have recruited 33 new research faculty from throughout...

By: IU School of Medicine On: August 6, 2018

NIH funds major biobank expansion at IU School of Medicine to support Alzheimer’s disease research

With a grant from the National Institute of Health's National Institute on Aging, Indiana University School of Medicine will dramatically increase the size and scope of the biobank that stores DNA and other biological samples used by researchers...

By: IU School of Medicine On: July 21, 2018

Expansion of Alzheimer’s disease biospecimens repository prompts name change

Indiana University School of Medicine's repository for biological samples used by the nation's Alzheimer's disease researchers is changing its name to the National Centralized Repository for Alzheimer’s Disease and Related Dementias."The new name reflects the significant...

By: IU School of Medicine On: July 20, 2018

IU researchers report problems with sense of smell may point to build-up of protein linked to Alzheimer’s disease

Problems identifying odors could be an early warning sign that the protein tau is building up in the brain, researchers have found. Tau is one of two proteins that are primary suspects in the development of Alzheimer's disease....

By: IU School of Medicine On: January 29, 2018

IU, Regenstrief Institute receive nearly $3 million to fund studies on aiding family caregivers of patients with dementia or traumatic brain injury

Family caregivers of individuals who have cognitive disorders are faced with complex and stressful challenges for which they are often unprepared and unsupported.Health services researcher Nicole Fowler, PhD, MHSA, of Indiana University School of Medicine, the IU...

By: IU School of Medicine On: December 18, 2017

IU awarded $7.6 million grant to establish groundbreaking study of early-onset Alzheimer’s disease

Indiana University School of Medicine has been awarded a one-year, $7.6 million grant from the National Institute on Aging (NIA) to establish a network of sites to study early-onset Alzheimer’s disease.The new NIA grant will help establish...

By: IU School of Medicine On: October 9, 2017

IU researchers help provide first look at atomic structures of protein tangles found in Alzheimer’s disease

INDIANAPOLIS – New research by scientists at the MRC Laboratory of Molecular Biology in the United Kingdom and Indiana University School of Medicine gives the most detailed view yet of tau protein structures found in Alzheimer’s disease.The...

By: IU School of Medicine On: July 5, 2017

IU, Regenstrief study explores adherence and tolerability to Alzheimer’s medications

INDIANAPOLIS -- Researchers from the Indiana University Center for Aging Research and the Regenstrief Institute have performed the first study conducted in the United States under real-world conditions comparing patient adherence and tolerability to a class of drugs...

By: IU School of Medicine On: April 11, 2017

Study finds occupational therapy unable to delay Alzheimer’s patients’ functional decline

INDIANAPOLIS – In the first study to investigate whether two years of in-home occupational therapy might help those with Alzheimer's disease delay the loss of their physical function, researchers from the Indiana Center for Aging Research and the Regenstrief...

By: IU School of Medicine On: November 21, 2016

Indiana University, Jackson Lab partner on new Alzheimer’s models seeking future therapies

INDIANAPOLIS and Bar Harbor, Maine — With the goal of breaking the bottleneck in developing new drugs to treat Alzheimer’s disease, the National Institute of Aging will provide $25 million over five years to establish and fund the Alzheimer’...

By: IU School of Medicine On: September 22, 2016

Indiana Alzheimer Disease Center success brings sixth consecutive five-year federal grant

INDIANAPOLIS -- Federal officials have recognized the research impact of scientists and physicians working on Alzheimer's disease at the Indiana University School of Medicine, awarding the school its sixth consecutive five-year grant for the Indiana Alzheimer Disease Center....

By: IU School of Medicine On: August 22, 2016

Researchers seek volunteers for study of Facebook app for Alzheimer’s caregivers

FOR IMMEDIATE RELEASEINDIANAPOLIS -- Can a caregiver of a person with Alzheimer's disease make meaningful use of a social networking site like Facebook? A team of researchers at Indiana University-Purdue University Indianapolis is looking for volunteers to participate...

By: IU School of Medicine On: July 29, 2016

IU researchers begin PET scans of certain older patients in new Alzheimer’s related study

INDIANAPOLIS -- In a new Alzheimer's disease-related initiative, Indiana University School of Medicine researchers have begun using PET brain scans to look for signs of abnormal protein deposits known as amyloid plaques in older patients who have been...

By: IU School of Medicine On: July 18, 2016

IU announces first round of funding for $300 million Grand Challenges program to Precision Health

INDIANAPOLIS -- Indiana University today announced that the Precision Health Initiative, a research initiative focused on patient-centered precision medicine therapies, is the first recipient of funding under the university’s new $300 million Grand Challenges Program. Led by faculty...

By: IU School of Medicine On: June 20, 2016

Researchers identify genes linked to the effects of mood and stress on longevity

INDIANAPOLIS -- The visible impacts of depression and stress that can be seen in a person's face -- and contribute to shorter lives -- can also be found in alterations in genetic activity, according to newly published research....

By: IU School of Medicine On: May 24, 2016

Research team at IUPUI develops social app to support Alzheimer’s caregivers

FOR IMMEDIATE RELEASEINDIANAPOLIS -- Every day, more than 15 million unpaid caregivers provide care to people with Alzheimer’s disease, with little outside support and often at the risk of their own health.Now a team of researchers, including...

By: IU School of Medicine On: March 18, 2016

IU, Regenstrief study: Cognitive training effects differ by older adult’s education level

INDIANAPOLIS -- The first study to investigate the effects of cognitive training on the cognitive functioning of older adults by education level has found that individuals with fewer than 12 years of schooling benefit more from cognitive training than...

By: IU School of Medicine On: January 28, 2016

Two Alzheimer’s risk genes linked to brain atrophy, promise future blood markers

INDIANAPOLIS -- Two genetic variants previously linked to Alzheimer's disease have been more specifically tied to brain atrophy that is characteristic of the disease.A newly reported study, led by Liana Apostolova, M.D., Barbara and Peer Baekgaard...

By: IU School of Medicine On: December 23, 2015

Researchers identify new gene linked to amyloid beta plaque buildup in Alzheimer’s disease

INDIANAPOLIS -- In a newly published study, a multi-institutional team led by scientists at the Indiana University School of Medicine have discovered an immune system gene associated with higher rates of amyloid plaque buildup in the brains of...

By: IU School of Medicine On: October 5, 2015

Tatiana Foroud named new chair of IU Department of Medical and Molecular Genetics

INDIANAPOLIS -- Tatiana Foroud, Ph.D., an internationally recognized genetic researcher who holds several leadership positions at the Indiana University School of Medicine, has been selected to be chair of the school's Department of Medical and Molecular Genetics....

By: IU School of Medicine On: September 15, 2015

IU medical, nursing and social work schools collaborate to win elder care initiative grant

INDIANAPOLIS -- Better health care for older adults and better training for those who care for them are the goals of a new Indiana University initiative for which clinicians and educators recently received a three-year award of nearly $2.6...

By: IU School of Medicine On: August 6, 2015

Study: Number of new cases of dementia decreasing for African-Americans but not Africans

INDIANAPOLIS -- An Indiana University and Regenstrief Institute study is the first to report significantly decreased incidence rates over two decades for Alzheimer's disease and other dementias in African-Americans. The study is also the first to show that...

By: IU School of Medicine On: August 4, 2015

Study identifies traits of those who screen positive for dementia but refuse diagnostic testing

INDIANAPOLIS -- Two thirds of individuals 65 and older who screened positive for cognitive impairment refused subsequent evaluation according to the first study of its kind to examine older adults willingness to undergo diagnostic assessment. The Indiana University Center...

By: IU School of Medicine On: July 16, 2015

Impact of major Alzheimer’s-related gene may be felt years before any symptoms appear

INDIANAPOLIS -- The best-known genetic variant linked to Alzheimer's disease may be "at work" promoting deposits of plaque in the brain long before any symptoms of the disease can be measured on tests, according to a national research...

By: IU School of Medicine On: July 13, 2015

IU Center for Aging Research eMR-ABC software improving brain care throughout Indiana

INDIANAPOLIS -- Older Indiana adults with dementia or depression will be among the best cared for elders in the nation beginning this month with the statewide roll-out of a unique automated decision-support system that enables their care coordinators...

By: IU School of Medicine On: May 7, 2015

Study: Majority of older adults willing to be screened by telephone for dementia

INDIANAPOLIS -- Nearly two-thirds of older adults were willing to undergo telephone screening for dementia, according to a new study from the Indiana University Center for Aging Research and the Regenstrief Institute. Willingness to be screened by phone...

By: IU School of Medicine On: May 1, 2015

Regenstrief investigator chosen for prestigious Charleston Conference on Alzheimer’s

INDIANAPOLIS -- Regenstrief Institute investigator and Indiana University Center for Aging Research scientist Noll Campbell, Pharm.D., is one of only 15 early career investigators nationwide selected to participate in the annual Charleston Conference on Alzheimer’s Disease in...

By: IU School of Medicine On: March 23, 2015

New NIH funding expands genetics research resources at IU Alzheimer Disease Center

INDIANAPOLIS -- The Indiana Alzheimer Disease Center has significantly boosted its resources for treating and researching the genetic underpinnings of Alzheimer's disease with an additional grant of $300,000 per year from the National Institutes of Health.The center, one...

By: IU School of Medicine On: February 26, 2015

IU-led research team identifies genetic variant linked to better memory performance

INDIANAPOLIS -- People with a newly identified genetic variant perform better on certain types of memory tests, a discovery that may point the way to new treatments for the memory impairments caused by Alzheimer's disease or other age-associated...

By: IU School of Medicine On: November 11, 2014

State-of-the-art IU Neuroscience Research Building to be dedicated Wednesday

INDIANAPOLIS -- Academic, scientific and health system leaders from Indiana University and IU Health will gather Wednesday to dedicate the new home of one of the nation's pre-eminent neuroscience research enterprises.The Indiana University Neurosciences Research building, which...

By: IU School of Medicine On: October 1, 2014

Back to basics: Redesigning systems of care for older adults with Alzheimer’s disease

INDIANAPOLIS -- The number of older adults with dementia in the United States is forecast to more than double over the next 40 years. Caring for these individuals will have a significant impact on caregivers as well as the...

By: IU School of Medicine On: April 8, 2014

Innovative, coordinated brain care could save billions of health care dollars

INDIANAPOLIS -- Studies have shown that a new patient and caregiver centered model of innovative, coordinated brain care for older adults improves health outcomes and quality of care for those with cognitive impairment. A new study from the...

By: IU School of Medicine On: April 8, 2014

On ‘Sound Medicine’: ‘Young invincibles,’ a president’s secret, and detecting autism

INDIANAPOLIS -- “Sound Medicine” announces its program for Sept. 22, with a conversation about young healthy adults and the Affordable Care Act, President Grover Cleveland’s secret surgery and designing a computer program to detect autism.Why should “young...

By: IU School of Medicine On: September 18, 2013

On ‘Sound Medicine’: Alzheimer’s X Prize, medical care for the elderly, and emergency room medicine

INDIANAPOLIS -- The award-winning “Sound Medicine” announces its program for Aug. 18, featuring several segments focusing on care for the elderly, including ethical medical decisions, the correlation between anesthesia and dementia, and a grant for Alzheimer’s research.How...

By: IU School of Medicine On: August 14, 2013

Fifth annual Memory University focusing on dementia scheduled for Thursdays in June

INDIANAPOLIS -- The Indiana Alzheimer Disease Center will present the fifth annual Memory University, “When It’s Not Just Memory,” from 1:30 to 3 p.m. Thursdays in June in the IU Health Neuroscience Center (Goodman Hall) auditorium, 355 W. 16 St.,...

By: IU School of Medicine On: May 31, 2013

IU scientists find second gene associated with Alzheimer’s disease plaques

A study combining genetic data with brain imaging, designed to identify genes associated with the amyloid plaque deposits found in Alzheimer’s disease patients, has not only identified the APOE gene -- long associated with development of Alzheimer’...

By: IU School of Medicine On: February 28, 2013

Genome-wide imaging study identifies new gene associated with Alzheimer’s plaques

A national research team, led by scientists at the Indiana University School of Medicine, reported the results of the study in an article in Molecular Psychiatry posted online Tuesday. The study is believed to be the first genome-wide...

By: IU School of Medicine On: February 20, 2013

IU and Regenstrief to collaborate with 19 Indiana nursing facilities to improve care

The IU and Regenstrief clinician-researchers have created  “OPTIMISTIC” -- “Optimizing Patient Transfers, Impacting Medical Quality and Improving Symptoms: Transforming Institutional Care” -- a comprehensive four-year initiative that will be targeted to 100-day or...

By: IU School of Medicine On: October 11, 2012

Groundbreaking ceremony set as construction begins on IU neurosciences research facility

The Indiana University Neurosciences Research Building, scheduled to open in 2014, will complete the second phase of the Indiana University Health Neuroscience Center at West 16th Street and North Senate Avenue. The research building will provide IU School...

By: IU School of Medicine On: August 3, 2012

Scientists mount genome research initiative to unlock Alzheimer’s genetic secrets

The new national initiative to research the genetics of Alzheimer’s disease, announced Monday, could have a dramatic impact on the development of treatments for the disease, said Indiana University School of Medicine researchers involved in the...

By: IU School of Medicine On: July 2, 2012

Study: Free, user-friendly ‘blood pressure cuff’ for dementia is reliable and valid

“The HABC Monitor is a 'blood pressure cuff' for dementia," said Regenstrief Institute investigator Malaz Boustani, M.D., MPH, associate professor of medicine and associate director of the IU Center for Aging Research. A geriatrician, Dr. Boustani...

By: IU School of Medicine On: June 14, 2012

2012 Memory University begins June 7

This series is a unique program for both professionals and families to learn more about Alzheimer's disease from nationally known clinicians affiliated with the Indiana Alzheimer Disease Center. Participants will learn the most up-to-date information and will...

By: IU School of Medicine On: June 5, 2012

Individuals With Dementia More Likely to Die at Home Than in Nursing Homes

“Transitions in Care for Older Adults With and Without Dementia” appears online in advance of publication in the May 2012 issue of the Journal of the American Geriatrics Society.Most individuals with dementia, even advanced dementia, die...

By: IU School of Medicine On: May 14, 2012

Study: Alzheimer’s drug fails to reduce significant agitation

 Previous studies suggested memantine could help reduce agitation and improve cognitive functions such as memory. Led by the University of East Anglia in the U.K., the new research found that while memantine does improve cognitive functioning...

By: IU School of Medicine On: May 2, 2012

Regenstrief extending successful aging brain care model globally

Through its ABC Program, the Senior Health Implementation Center will disseminate ABC tools including a how-to manual for clinicians, a dementia symptoms monitor and resource handbook for caregivers, as well as providing onsite training. The new center and...

By: IU School of Medicine On: May 2, 2012

Geriatrician from Regenstrief Institute and Indiana University Honored

Dr. Boustani is a geriatrician. He is associate director of the IU Center for Aging Research and medical director of the Healthy Aging Brain Center at Wishard Health Services. He leads the Indianapolis Discovery Network for Dementia and...

By: IU School of Medicine On: February 14, 2012

Nursing Home Scorecards Are Misleading — This Week on Sound Medicine

Sound Medicine airs at 2 p.m. Sunday, Jan. 15, on WFYI, 90.1 FM. For the airtime on a public radio station near you, check the Sound Medicine website. Evaluating nursing homes. Government agencies use a standardized rating system for...

By: IU School of Medicine On: January 11, 2012

Indiana Alzheimer Disease Center Receives $9.1 Million from NIH to Continue Dementia Research

The grant will enable the Indiana center’s scientists and doctors to continue their work in state-of-the-art research aimed at developing better understanding of the causes and potential treatments for Alzheimer disease and other dementias, said Bernardino...

By: IU School of Medicine On: November 1, 2011

$8.4 Million Grant Supports Health Information Exchange and Research On Alzheimer’s Drugs

The grant simultaneously supports a groundbreaking comparative effectiveness research study using data from the INPC to compare the benefits and harms of three drugs commonly used to treat Alzheimer’s disease.Both the infrastructure expansion, already underway,...

By: IU School of Medicine On: October 10, 2011

Defining Essential Health Insurance Benefits, This Week on Sound Medicine

Essential health insurance benefits. Since the passage of the Affordable Care Act last year, actuaries at insurance companies have been working out the coverage and benefit details. Sound Medicine’s health policy analyst, Aaron Carroll, M.D.,...

By: IU School of Medicine On: March 31, 2011

New Mode of Dementia Care Improves Health, Lowers Hospitalization Rates

The paper appears in Volume 15, Issue 1, 2011 of the peer-reviewed journal Aging & Mental Health.“We successfully translated the memory care model we developed into actual practice, taking it from promising research to a clinical trial, which we...

By: IU School of Medicine On: February 10, 2011

A New Look at the Beta Amyloid Protein in Alzheimer’s Disease, This Week on Sound Medicine

A Washington University School of Medicine neurologist, Dr. Bateman will discuss his view on the common belief that the brain’s over-production of the beta amyloid protein causes Alzheimer’s disease. His research shows that the...

By: IU School of Medicine On: February 2, 2011

Cerebrospinal Fluid Study Reveals Potential New Gene Associated with Alzheimer’s Disease

The research team conducted a genome-wide analysis of potential CSF biomarkers that could be used for early detection of Alzheimer’s disease, using samples from 374 participants in the national Alzheimer’s Disease Neuroimaging Initiative (ADNI).“...

By: IU School of Medicine On: December 13, 2010

Multiple Organ Transplants, This Week on Sound Medicine

Dr. Rodrigo Vianna, director of intestinal and multivisceral transplantation at Clarian Hospital, is one of the few surgeons in the world who can perform multiple-organ transplant surgery -- a procedure to replace just about everything in the patient&...

By: IU School of Medicine On: September 23, 2010

Indianapolis to Host International Conference on Frontotemporal Dementias

The conference provides a rare opportunity for caregivers and researchers to meet and share information in a context that instills a new understanding of the complexities of this disease. Originally known as Pick’s disease, frontotemporal dementia...

By: IU School of Medicine On: September 7, 2010

This Week on Sound Medicine — Dec.5

The program:Sound Medicine producer Colleen Iudice will report on a controversy in Indiana where dentists are protesting a proposal to stop adding fluoride to water.Indiana Rep. Vanessa Summers will discuss a national effort to improve mental...

By: IU School of Medicine On: December 2, 2009

Alzheimer’s Disease Patients Sought For Study of Dietary Product

The supplement, Souvenaid®, is taken once a day as a beverage. Participants must be 50 years of age and be available to participate in the 28-week study, which requires six visits to the IU Medical Center.For more...

By: IU School of Medicine On: October 16, 2009

Alzheimer’s Disease Research Seeks Volunteers for Clinical Study

The drug, bapineuzumab, is an antibody, which is a protein usually produced by white blood cells to destroy foreign substances in the body. In this use, it is hoped bapineuzumab will attack the amyloid protein in the brain...

By: IU School of Medicine On: September 29, 2009

Indiana Alzheimer Disease Center to host showing of ‘The Alzheimer’s Project’

Following the screening, IADC faculty members from the Indiana University School of Medicine will be available to answer questions about Alzheimer disease, current diagnosis, treatment and promising areas of research.This program is free and open to the...

By: IU School of Medicine On: May 22, 2009

This Week on Sound Medicine — April 26

Sound Medicine reporter Shia Levitt will explore the growing phenomenon of baby boomers who are returning to illicit drug use of their younger years and forcing managers of drug rehabilitation programs to face new challenges dealing with boomers&...

By: IU School of Medicine On: April 22, 2009

Alzheimer’s Disease Neuroimaging Initiative Announces Completion of Genome-Wide Analysis

The ADNI data will be used by researchers to search for genes that contribute to the development of Alzheimer’s disease, which currently affects up to 5 million people in the United States alone.ADNI, an ongoing $60 million...

By: IU School of Medicine On: March 16, 2009

Telehealth for Diabetes Promotes Aging at Home, Not in the Hospital

The study of 387 diabetics and 387 individuals without diabetes appears in the March 2009 issue of the Journal of Telemedicine and Telecare.The researchers, led by Neale Chumbler, Ph.D., professor of sociology at Indiana University-Purdue University Indianapolis’s...

By: IU School of Medicine On: March 12, 2009

Cholinesterase Inhibitors Reduce Aggression, Wandering and Paranoia in Alzheimer’s disease

Investigators from the Indiana University School of Medicine, the Regenstrief Institute and Wishard Health Services reviewed nine randomized, double-blind, placebo-controlled clinical trials evaluating the effectiveness of three popular cholinesterase inhibitors in managing behavioral and psychological symptoms displayed by...

By: IU School of Medicine On: December 9, 2008

Caring for the Caregiver: Redefining the Definition of Patient -IU Study Finds 25% of family caregivers of AD patients Go To ER Or Are Hospitalized

Researchers from the Indiana University School of Medicine, the Regenstrief Institute and the Indiana University Center for Aging Research report in a new study that a quarter of family caregivers of Alzheimer’s dementia patients had at...

By: IU School of Medicine On: November 10, 2008

This Week on Sound Medicine — August 3

Ezekiel Emanuel, M.D., Ph.D., director of clinical bioethics at the National Institutes of Health, will discuss his new book, Healthcare, Guaranteed. In it, he proposes a different and more efficient health-care plan. Dr. Emanuel is an...

By: IU School of Medicine On: July 30, 2008

Neurological Assessment of Older Adults: A Crystal Ball to the Future

The editorial accompanies a study by Italian researchers who used data obtained from standardized neurological exams to devise a simple scale measuring the total number of subtle neurological abnormalities found among disability-free older adults. The Italian study found...

By: IU School of Medicine On: June 24, 2008

This Week on Sound Medicine — March 30

Co-host David Crabb, M.D., will speak with Alan Rogol, M.D., Ph.D., professor of clinical pediatrics at Indiana University School of Medicine and the University of Virginia Health System, about the health effects on athletes who...

By: IU School of Medicine On: March 26, 2008

Registration Open for Mild Cognitive Impairment 2-Day Workshop

The first day, specialists from across the country will focus on "Mild Cognitive Impairment: An Evolving Concept in Research and Clinical Practice." This scientific program highlights current concepts in the diagnosis, genetics, imaging and therapy associated with mild...

By: IU School of Medicine On: February 26, 2008

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