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<p>This weekend, April 26 and 27, Sound Medicine, the award-winning weekly radio program hosted by Barbara Lewis, focuses on gene mutations and breast cancer, diabetes in women, and optimism and the brain.</p>

This Week on Sound Medicine — April 27

Sound Medicine reporter Shia Levitt will speak with Carol Galaty, a woman who, after special testing, discovered she carried a genetic mutation linked to an elevated risk for breast and ovarian cancer . She also will address the impact of this risk on her daughters’ lives.

Ann Goebel-Fabbri, Ph.D., an instructor of psychiatry at Harvard Medical School and investigator in behavioral and mental health at Joslin Diabetes Center, will talk about diabulimia, where women with type 1 diabetes deliberately take less insulin than prescribed. A new study found these women had a three-fold increased risk of death and higher rates of disease complications and also exhibited eating disorder symptoms and behaviors .

Why do some people anticipate the worst while others have an optimistic outlook? A new study has identified a small part of the mid-brain, the rostral anterior cingulate cortex (rACC), as the area responsible for optimism. Cognitive neuroscientist Elizabeth Phelps, Ph.D., of New York University and co-author of the study, will discuss the findings.

Also, Allen Zadoff, a writer and teacher in L.A., will discuss his book “Hungry: Lessons Learned on a Journey From Fat to Thin,” a memoir about recognizing his food addiction, changing his eating habits and how he continues to maintain a healthy weight.

Archived editions of Sound Medicine as well as other helpful information can be found at http://www.soundmedicine.iu.edu.

Sound Medicine is underwritten by the Lilly Center for Medical Science, Clarian Health, and IU Medical Group; Jeremy Shere’s “Check-Up” is underwritten by IUPUI.