Mohammad Yaseen Abbasi, PhD
No current publications.
Aymin Akil, PhD
Costantine Albany, MD
TBA.
Abdulateef Aregbe, MD
Aregbe AO, Sherer EA, Egorin MJ, Scher HI, Solit DB, Ramanathan RK, Ramalingam S, Belani CP, Ivy PS, Bies RR. Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors. Cancer Chemother Pharmacol. 2012 Jul. PMID: 22450873. PMCID: PMC3383947.
Blessed Winston Arul Dhas, MD
Alyson Baker, MD
TBA.
Nadia Bamfo, PharmD*
Bamfo NO, Hosey-Cojocari C, Benet LZ, Remsberg CM. Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. Pharm Res. 2021 Jul;38(7):1139-1156. doi: 10.1007/s11095-021-03076-y. Epub 2021 Jul 12. PMID: 34254223.
Jason Bazil, PhD
Lauren A. Bell, MD, MPH*
Adams ZW, Agley J, Pederson CA, Bell LA, Aalsma MC, Jackson T, Grant MT, Ott CA, Hulvershorn LA. Use of Project ECHO to promote evidence based care for justice involved adults with opioid use disorder. Subst Abus. 2022;43(1):336-343. doi: 10.1080/08897077.2021.1941518. Epub 2021 Jul 20. PMID: 34283701; PMCID: PMC8889500.
Nicole Bell, PhD*
TBA.
Eric Benson, PhD, MD*
Ramamoorthy A, Li L, Gaedigk A, Bradford LD, Benson EA, Flockhart DA, Skaar TC. In Silico and In Vitro Identification of MicroRNAs that Regulate HNF4A Expression. Drug Metab Dispos. 2012 Jan 9. [Epub ahead of print]. PMID: 22232426. PMCID: PMC3310421.
Benson, EA, Skaar TC. Incubation of whole blood at room temperature does not alter the plasma concentrations of microRNA-16 and -223. Drug Metab Dispos. 2013 Oct. PMID: 23886700. PMCID: PMC3781369.
Burgess KS, Philips S, Benson EA, Desta Z, Gaedigk A, Gaedigk R, Segar MW, Liu Y, Skaar TC. Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver. Clin Pharmacol Ther. 2015 Aug;98(2):205-15. PMID: 25968989; PMCID: PMC4512918.
Benson EA, Skaar TC, Liu Y, Nephew KP, Matei D. Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study. PLoS One. 2015 Oct 20;10(10):e0141279. PMID: 26485143; PMCID: PMC4612782.
Eadon MT, Desta Z, Levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dave N, Robarge JD, Hyder MA, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clin Pharmacol Ther. 2016 Jul;100(1):63-6. -Epub 2016 Mar 31. PMID: 26850569; PMCID: PMC4899152.
Benson EA, Eadon MT, Desta Z, Liu Y, Lin H, Burgess KS, Segar MW, Gaedigk A, Skaar TC. Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111. PMID: 27199754; PMCID: PMC4845040.
Eadon MT, Hause RJ, Stark AL, Cheng YH, Wheeler HE, Burgess KS, Benson EA, Cunningham PN, Bacallao RL, Dagher PC, Skaar TC, Dolan ME. Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach. Int J Mol Sci. 2017 Mar 18;18(3):661. PMID: 28335481; PMCID: PMC5372673.
Eadon MT, Cheng YH, Hato T, Benson EA, Ipe J, Collins KS, De Luca T, El- Achkar TM, Bacallao RL, Skaar TC, Dagher PC. In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice. J Drug Deliv. 2017;2017:4070793. Epub 2017 Dec 20. PMID: 29410918; PMCID: PMC5750491.
Surya Bhamidipaty-Pelosi, MD, MS, DRANZCOG
No current publications.
Carla Biesdorf de Almeida, PhD
Silvana Borges-Gonzalez, MD
Josiane Cardoso
TBA.
Shripad Chitnis, PhD
Vélez de Mendizábal N, Strother RM, Farag SS, et al. Modelling the sitagliptin effect on dipeptidyl peptidase-4 activity in adults with haematological malignancies after umbilical cord blood haematopoietic cell transplantation. Clin Pharmacokinet. 2014;53(3):247-259. doi:10.1007/s40262-013-0109-y
Doo-Yeoun Cho, MD
Kimberly Collins, PhD
Melo Ferreira, R., Sabo, A. R., Winfree, S., Collins, K. S., Janosevic, D., Gulbronson, C. J., Cheng, Y. H., Casbon, L., Barwinska, D., Ferkowicz, M. J., Xuei, X., Zhang, C., Dunn, K. W., Kelly, K. J., Sutton, T. A., Hato, T., Dagher, P. C., El-Achkar, T. M., & Eadon, M. T. (2021). Integration of spatial and single-cell transcriptomics localizes epithelial cell-immune cross-talk in kidney injury. JCI insight, 6(12), e147703. https://doi.org/10.1172/jci.insight.147703
Janosevic, D., Myslinski, J., McCarthy, T. W., Zollman, A., Syed, F., Xuei, X., Gao, H., Liu, Y. L., Collins, K. S., Cheng, Y. H., Winfree, S., El-Achkar, T. M., Maier, B., Melo Ferreira, R., Eadon, M. T., Hato, T., & Dagher, P. C. (2021). The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline. eLife, 10, e62270. https://doi.org/10.7554/eLife.62270
Collins, K. S., Raviele, A. L. J., Elchynski, A. L., Woodcock, A. M., Zhao, Y., Cooper-DeHoff, R. M., & Eadon, M. T. (2020). Genotype-Guided Hydralazine Therapy. American journal of nephrology, 51(10), 764–776. https://doi.org/10.1159/000510433
Collins, K. S., Eadon, M. T., Cheng, Y. H., Barwinska, D., Melo Ferreira, R., McCarthy, T. W., Janosevic, D., Syed, F., Maier, B., El-Achkar, T. M., Kelly, K. J., Phillips, C. L., Hato, T., Sutton, T. A., & Dagher, P. C. (2022). Alterations in Protein Translation and Carboxylic Acid Catabolic Processes in Diabetic Kidney Disease. Cells, 11(7), 1166. https://doi.org/10.3390/cells11071166
Eadon, M. T., Lampe, S., Baig, M. M., Collins, K. S., Melo Ferreira, R., Mang, H., Cheng, Y. H., Barwinska, D., El-Achkar, T. M., Schwantes-An, T. H., Winfree, S., Temm, C. J., Ferkowicz, M. J., Dunn, K. W., Kelly, K. J., Sutton, T. A., Moe, S. M., Moorthi, R. N., Phillips, C. L., Dagher, P. C., … Kidney Precision Medicine Project (2021). Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 37(1), 72–84. https://doi.org/10.1093/ndt/gfaa331
Barwinska, D., El-Achkar, T. M., Melo Ferreira, R., Syed, F., Cheng, Y. H., Winfree, S., Ferkowicz, M. J., Hato, T., Collins, K. S., Dunn, K. W., Kelly, K. J., Sutton, T. A., Rovin, B. H., Parikh, S. V., Phillips, C. L., Dagher, P. C., Eadon, M. T., & Kidney Precision Medicine Project (2021). Molecular characterization of the human kidney interstitium in health and disease. Science advances, 7(7), eabd3359. https://doi.org/10.1126/sciadv.abd3359
Spiech, K. M., Tripathy, P. R., Woodcock, A. M., Sheth, N. A., Collins, K. S., Kannegolla, K., Sinha, A. D., Sharfuddin, A. A., Pratt, V. M., Khalid, M., Hains, D. S., Moe, S. M., Skaar, T. C., Moorthi, R. N., & Eadon, M. T. (2020). Implementation of a Renal Precision Medicine Program: Clinician Attitudes and Acceptance. Life (Basel, Switzerland), 10(4), 32. https://doi.org/10.3390/life10040032
Eadon, M. T., Cheng, Y. H., Hato, T., Benson, E. A., Ipe, J., Collins, K. S., De Luca, T., El-Achkar, T. M., Bacallao, R. L., Skaar, T. C., & Dagher, P. C. (2017). In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice. Journal of drug delivery, 2017, 4070793. https://doi.org/10.1155/2017/4070793
Collins, K. S., Cheng, Y. H., Ferreira, R. M., Gao, H., Dollins, M. D., Janosevic, D., Khan, N. A., White, C., Dagher, P. C., & Eadon, M. T. (2020). Interindividual Variability in Lymphocyte Stimulation and Transcriptomic Response Predicts Mycophenolic Acid Sensitivity in Healthy Volunteers. Clinical and translational science, 13(6), 1137–1149. https://doi.org/10.1111/cts.12795
Edwards, M. E., De Luca, T., Ferreira, C. R., Collins, K. S., Eadon, M. T., Benson, E. A., Sobreira, T. J. P., & Cooks, R. G. (2021). Multiple reaction monitoring profiling as an analytical strategy to investigate lipids in extracellular vesicles. Journal of mass spectrometry : JMS, 56(1), e4681. https://doi.org/10.1002/jms.4681
Nimita Dave, PhD*
Dave N, Chow LM, Gudelsky GA, LaSance K, Qi X, Desai PB. Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas. Mol Cancer Ther. 2015 Apr;14(4):857-64. doi: 10.1158/1535-7163.MCT-14-0743. PMID: 25695958. PMCID: PMC4631403.
Tom DeLuca, PhD
De Luca T, Stratford RE Jr, Edwards ME, Ferreira CR, Benson EA. Novel Quantification of Extracellular Vesicles with Unaltered Surface Membranes Using an Internalized Oligonucleotide Tracer and Applied Pharmacokinetic Multiple Compartment Modeling. Pharm Res. 2021 Oct;38(10):1677-1695. doi: 10.1007/s11095-021-03102-z. Epub 2021 Oct 20. PubMed PMID: 34671921; PubMed Central PMCID: PMC8602176.
Edwards ME, De Luca T, Ferreira CR, Collins KS, Eadon MT, Benson EA, Sobreira TJP, Cooks RG. Multiple reaction monitoring profiling as an analytical strategy to investigate lipids in extracellular vesicles. J Mass Spectrom. 2021 Jan;56(1):e4681. doi: 10.1002/jms.4681. Epub 2020 Nov 18. PubMed PMID: 33210411; PubMed Central PMCID: PMC7941191.
De Luca T, Stratford R, Edwards M, Ferreira C, Benson E. Quantification of extracellular vesicles with unaltered surface membranes using an internalized oligonucleotide tracer and droplet digital PCR applied to modeling of <i>in vivo</i> kinetics. [preprint]. 2020 September. doi: 10.1101/2020.09.22.306969.
Fulton CR, Swart M, De Luca T, Liu SN, Collins KS, Desta Z, Gufford BT, Eadon MT. Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness. J Nurse Pract. 2018 Nov-Dec;14(10):697-704.e1. doi: 10.1016/j.nurpra.2018.09.021. Epub 2018 Nov 2. PubMed PMID: 30555285; PubMed Central PMCID: PMC6291225.
De Luca T, Szilágyi KL, Hargreaves KA, Collins KS, Benson EA. Improving the Patency of Jugular Vein Catheters in Sprague-Dawley Rats by Using an Antiseptic Nitrocellulose Coating. J Am Assoc Lab Anim Sci. 2018 Sep 1;57(5):520-528. doi: 10.30802/AALAS-JAALAS-18-000017. Epub 2018 Aug 3. PubMed PMID: 30075826; PubMed Central PMCID: PMC6159680.
Eadon M, Cheng Y, Hato T, Benson E, Ipe J, Collins K, De Luca T, El-Achkar T, Bacallao R, Skaar T, Dagher P. <i>In Vivo</i> siRNA Delivery and Rebound of Renal <i>LRP2</i> in Mice. Journal of Drug Delivery. 2017 December; 2017:1-12. doi: 10.1155/2017/4070793.
Allen KT, Chin-Sinex H, DeLuca T, Pomerening JR, Sherer J, Watkins JB 3rd, Foley J, Jesseph JM, Mendonca MS. Dichloroacetate alters Warburg metabolism, inhibits cell growth, and increases the X-ray sensitivity of human A549 and H1299 NSC lung cancer cells. Free Radic Biol Med. 2015 Dec;89:263-73. doi: 10.1016/j.freeradbiomed.2015.08.006. Epub 2015 Sep 21. PubMed PMID: 26393423.
Yuan X, Srividhya J, De Luca T, Lee JH, Pomerening JR. Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset. Mol Biol Cell. 2014 Feb;25(4):441-56. doi: 10.1091/mbc.E13-08-0480. Epub 2013 Dec 19. PubMed PMID: 24356446; PubMed Central PMCID: PMC3923637.
Wu LY, De Luca T, Watanabe T, Morré DM, Morré DJ. Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol. Biochim Biophys Acta. 2011 Aug;1810(8):784-9. doi: 10.1016/j.bbagen.2011.04.011. Epub 2011 May 5. PubMed PMID: 21571040.
De Luca T, Morré DM, Morré DJ. Reciprocal relationship between cytosolic NADH and ENOX2 inhibition triggers sphingolipid-induced apoptosis in HeLa cells. J Cell Biochem. 2010 Aug 15;110(6):1504-11. doi: 10.1002/jcb.22724. PubMed PMID: 20518072.
De Luca T, Bosneaga E, Morré DM, Morré DJ. Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol. Biofactors. 2008;34(3):253-60. doi: 10.3233/BIO-2009-1079. PubMed PMID: 19734127.
De Luca T, Morré DM, Zhao H, Morré DJ. NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. Biofactors. 2005;25(1-4):43-60. doi: 10.1002/biof.5520250106. PubMed PMID: 16873929.
Mehul G. Desai, MD*
Gorski, J. C., Huang, S. M., Pinto, A., Hamman, M. A., Hilligoss, J. K., Zaheer, N. A., Desai, M., Miller, M., & Hall, S. D. (2004). The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clinical pharmacology and therapeutics, 75(1), 89–100. https://doi.org/10.1016/j.clpt.2003.09.013
Li, L., Desai, M., Desta, Z., & Flockhart, D. (2004). QT analysis: a complex answer to a 'simple' problem. Statistics in medicine, 23(17), 2625–2643. https://doi.org/10.1002/sim.1863
Jardine, M. J., Mahaffey, K. W., Neal, B., Agarwal, R., Bakris, G. L., Brenner, B. M., Bull, S., Cannon, C. P., Charytan, D. M., de Zeeuw, D., Edwards, R., Greene, T., Heerspink, H. J. L., Levin, A., Pollock, C., Wheeler, D. C., Xie, J., Zhang, H., Zinman, B., Desai, M., … CREDENCE study investigators (2017). The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics. American journal of nephrology, 46(6), 462–472. Advance online publication. https://doi.org/10.1159/000484633
Desai, M., Li, L., Desta, Z., Malik, M., & Flockhart, D. (2003). Variability of heart rate correction methods for the QT interval. British journal of clinical pharmacology, 55(6), 511–517. https://doi.org/10.1046/j.1365-2125.2003.01791.x
Anh Duong, PharmD*
No publications.
Omar El Jordi, PhD
No current publications.
Noam Epstein, MD*
Nadia Falah, MD*
Falah, N., & Haas, D. M. (2014). Antenatal corticosteroid therapy: current strategies and identifying mediators and markers for response. Seminars in perinatology, 38(8), 528–533. https://doi.org/10.1053/j.semperi.2014.08.018
Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Brustovetsky, N., Srour, E. F., Lee, M. R., Messina-Graham, S., Haas, D. M., Falah, N., Kapur, R., Pelus, L. M., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S., & Broxmeyer, H. E. (2015). Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock. Cell, 161(7), 1553–1565. https://doi.org/10.1016/j.cell.2015.04.054
Michael Ferguson, MD
TBA.
Ricardo Melo Ferreira, PhD
Cathy Fulton, DNP, RN*
Fulton CR, Clark C, Dickinson S. Clinical Hours in Nurse Practitioner Programs Equals Clinical Competence: Fact or Misnomer? Nurse Educ. 2017 Jul/Aug;42(4):195-198. doi: 10.1097/NNE.0000000000000346. PMID: 27922898.
Fulton CR, Swart M, De Luca T, Liu SN, Collins KS, Desta Z, Gufford BT, Eadon MT. Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness. J Nurse Pract. 2018 Nov-Dec;14(10):697-704.e1. doi: 10.1016/j.nurpra.2018.09.021. Epub 2018 Nov 2. PMID: 30555285; PMCID: PMC6291225.
Fulton CR, Zang Y, Desta Z, Rosenman MB, Holmes AM, Decker BS, Zhang Y, T Callaghan J, Pratt VM, Levy KD, Gufford BT, Dexter PR, Skaar TC, Eadon MT. Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial. Pharmacogenomics. 2019 Apr;20(6):397-408. doi: 10.2217/pgs-2018-0205. Epub 2019 Feb 20. PMID: 30784356; PMCID: PMC6562829.
Yemi Gafari, PharmD, MBA
No current publications.
Tonia Gardner Thompson, MD
TBA.
Debora Gisch, PhD
Melo Ferreira R, Gisch DL, Eadon MT. Spatial transcriptomics and the kidney. Curr Opin Nephrol Hypertens. 2022 May 1;31(3):244-250. doi: 10.1097/MNH.0000000000000781. Epub 2022 Feb 3. PMID: 35125393; PMCID: PMC9035033.
Avin KG, Hughes MC, Chen NX, Srinivasan S, O'Neill KD, Evan AP, Bacallao RL, Schulte ML, Moorthi RN, Gisch DL, Perry CGR, Moe SM, O'Connell TM. Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease. Sci Rep. 2021 May 7;11(1):9788. doi: 10.1038/s41598-021-89120-8. PMID: 33963215; PMCID: PMC8105324.
Ellen Go, MD
Go, E., & Yoder, M. C. (2021). Identification of Endothelial Cells and Their Progenitors. Methods in molecular biology (Clifton, N.J.), 2206, 27–37. https://doi.org/10.1007/978-1-0716-0916-3_3
Go, E. J. L., & O'Neil, K. M. (2017). The catastrophic antiphospholipid syndrome in children. Current opinion in rheumatology, 29(5), 516–522. https://doi.org/10.1097/BOR.0000000000000426
Go, E., Tarnawsky, S. P., Shelley, W. C., Banno, K., Lin, Y., Gil, C. H., Blue, E. K., Haneline, L. S., O'Neil, K. M., & Yoder, M. C. (2018). Mycophenolic acid induces senescence of vascular precursor cells. PloS one, 13(3), e0193749. https://doi.org/10.1371/journal.pone.0193749
Aeschlimann, F. A., Batu, E. D., Canna, S. W., Go, E., Gül, A., Hoffmann, P., Leavis, H. L., Ozen, S., Schwartz, D. M., Stone, D. L., van Royen-Kerkof, A., Kastner, D. L., Aksentijevich, I., & Laxer, R. M. (2018). A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease. Annals of the rheumatic diseases, 77(5), 728–735. https://doi.org/10.1136/annrheumdis-2017-212403
Brandon T. Gufford, PharmD, PhD*
Eadon MT, Desta Z, Levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dave N, Robarge JD, Hyder MA, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clin Pharmacol Ther. 2016 Feb 6. doi:10.1002/cpt.347. [Epub ahead of print] Review. PMID: 26850569 PMCID: PMC4899152.
Gufford BT, Lu JB, Metzger IF, Jones DR, Desta Z. Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo. Drug Metab Dispos. 2016 Apr;44(4):544-53. Epub 2016 Jan 22. Erratum in: Drug Metab Dispos. 2016 Nov;44(11):1852. PMID: 26802129; PMCID: PMC4810769.
Andrea R. Masters, Brandon T. Gufford, Jessica Bo Li Lu, Ingrid F. Metzger, David R. Jones, and Zeruesenay Desta. Chiral plasma pharmacokinetics and urinary excretion of bupropion and metabolites in healthy volunteers. J Pharmacol Exp Ther. 2016 Aug; 358(2):230-8. PMID: 27255113. PMCID: PMC4959100. [Available on 2017-08-01]
, Desta Z, Eadon MT. Clinical and educational impact of pharmacogenomics testing: a case series from the INGENIOUS trial. Pharmacogenomics. 2017 Jun;18(9):835-841. Epub 2017 Jun 8. PMID: 28594278; PMCID: PMC5591461.Gufford BTPierson RC,
Gufford BT, Robarge JD, Eadon MT, Gao H, Lin H, Liu Y, Desta Z, Skaar TC. Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes. Pharmacol Res Perspect. 2018 Mar 26;6(2):e00386. PMID: 29610665; PMCID: PMC5869567.
, Thong N, Desta Z, Gaedigk R, Pearce RE, Gaedigk A, Liu Y, Skaar TC. Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs. Clin Pharmacol Ther. 2018 Jul;104(1):130-138. Epub 2017 Oct 25. PMID: 28960269; PMCID: PMC5871545.Gufford BTBurgess KS, Ipe J, Swart M, Metzger IF, Lu J,
, Eadon MT. Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness. J Nurse Pract. 2018 Nov-Dec;14(10):697-704.e1. Epub 2018 Nov 2. PMID: 30555285; PMCID: PMC6291225.Gufford BTFulton CR, Swart M, De Luca T, Liu SN, Collins KS, Desta Z,
, Dexter PR, Skaar TC, Eadon MT. Drug- gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial. Pharmacogenomics. 2019 Apr;20(6):397-408. Epub 2019 Feb 20. PMID: 30784356; PMCID: PMC6562829.Gufford BTFulton CR, Zang Y, Desta Z, Rosenman MB, Holmes AM, Decker BS, Zhang Y, T Callaghan J, Pratt VM, Levy KD,
. Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors. Drug Metab Dispos. 2019 May;47(5):535-544. Epub 2019 Feb 25. PMID: 30804050; PMCID: PMC6474910., Gufford BTLiu SN, Lu JBL, Watson CJW, Lazarus P, Desta Z
. Probenecid-Boosted Tenofovir: A Physiologically- Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis. CPT Pharmacometrics Syst Pharmacol. 2020 Jan;9(1):40-47. Epub 2019 Dec 23. PMID: 31749296; PMCID: PMC6966182.Gufford BTLiu SN, Desta Z,
, Lu JB, Medeiros EB, Pratt VM, Skaar TC, Desta Z. Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers. Drug Metab Dispos. 2020 Mar;48(3):169-175. Epub 2019 Dec 30. PMID: 31888882; PMCID: PMC7011111.Gufford BTCollins KS, Metzger IF,
, Lu JBL, Bushman LR, Anderson PL, Bergstrom RF, Desta Z, Gupta SK. Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis. Clin Pharmacol Ther. 2020 May;107(5):1200-1208. Epub 2019 Dec 31. PMID: 31675437; PMCID: PMC7703849Gufford BTLiu SN,
, Desta Z, Liu Y, Skaar TC. Circulating miRNAs as Biomarkers for CYP2B6 Enzyme Activity. Clin Pharmacol Ther. 2021 Feb;109(2):485-493. Epub 2020 Oct 5. PMID: 32772362.Gufford BTIpe J, Li R, Metzger IF, Bo Li Lu J,
Abhishek Gulati, PhD
. (2018). An Evaluation of a Factor Xa-Based Clotting Time Test for Enoxaparin: A Proof-of-Concept Study. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 24(4), 669–676. https://doi.org/10.1177/1076029617711802Gulati, ANg, D. P. J., Duffull, S. B., Faed, J. M., Isbister, G. K., &
., Faed, J. M., Isbister, G. K., & Duffull, S. B. (2015). Application of Adaptive DP-optimality to Design a Pilot Study for a Clotting Time Test for Enoxaparin. Pharmaceutical research, 32(10), 3391–3402. https://doi.org/10.1007/s11095-015-1715-1Gulati, A
., Dhanikula, R. S., Gokemeijer, J., Leil, T. A., Thalhauser, C. J., Giorgi, M., Swat, M. J., Chelliah, V., Small, B. G., Benson, N., … van der Graaf, P. H. (2019). A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins. CPT: pharmacometrics & systems pharmacology, 8(11), 773–776. https://doi.org/10.1002/psp4.12465Gulati, AKierzek, A. M., Hickling, T. P., Figueroa, I., Kalvass, J. C., Nijsen, M., Mohan, K., Veldman, G. M., Yamada, A., Sayama, H., Yokoo, S.,
., Bagnato, F., Villoslada, P., & Velez de Mendizabal, N. (2015). A Population Approach to Characterize Interferon Beta-1b Effect on Contrast Enhancing Lesions in Patients With Relapsing Remitting Multiple Sclerosis. CPT: pharmacometrics & systems pharmacology, 4(5), 295–304. https://doi.org/10.1002/psp4.36Gulati, A
Segewkal Hawaze Heruye, PhD
No current publications.
Herbert Ho, MD
Jin, Y., Desta, Z., Stearns, V., Ward, B., Ho, H., Lee, K. H., Skaar, T., Storniolo, A. M., Li, L., Araba, A., Blanchard, R., Nguyen, A., Ullmer, L., Hayden, J., Lemler, S., Weinshilboum, R. M., Rae, J. M., Hayes, D. F., & Flockhart, D. A. (2005). CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. Journal of the National Cancer Institute, 97(1), 30–39. https://doi.org/10.1093/jnci/dji005
Ho, H., Pinto, A., Hall, S. D., Flockhart, D. A., Li, L., Skaar, T. C., Cadman, P., O'Connor, D. T., Wagner, U., Fineberg, N. S., & Weinberger, M. H. (2005). Association between the CYP3A5 genotype and blood pressure. Hypertension (Dallas, Tex. : 1979), 45(2), 294–298. https://doi.org/10.1161/01.HYP.0000151361.31736.96
Rosenshein, B., Flockhart, D. A., & Ho, H. (2004). Induction of testosterone metabolism by esomeprazole in a CYP2C19*2 heterozygote. The American journal of the medical sciences, 327(5), 289–293. https://doi.org/10.1097/00000441-200405000-00032
Thang Ho, PhD
Woo Seong Huh, MD
TBA.
Jung-Won Hwang, MD, PhD
TBA.
Mustafa Hyder, MD*
Eadon MT, Desta Z, levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dove N, Robarge JD, Hyder MA, Gupta SK, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clinical Pharmacology & Therapeutics. 2016. ePub Feb G. PMID: 26850569. PMCID: PMC4899152
Chetna Jadala, PhD
No current publications.
Seongwook Jeong, MD, PhD
Jeong, S., Woo, M. M., Flockhart, D. A., & Desta, Z. (2009). Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer chemotherapy and pharmacology, 64(5), 867–875. https://doi.org/10.1007/s00280-009-0935-7
Jeong, S., Nguyen, P. D., & Desta, Z. (2009). Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A. Antimicrobial agents and chemotherapy, 53(2), 541–551. https://doi.org/10.1128/AAC.01123-08
Yan Jin, MD, MS*
Kreutz RP, Owens J, Jin Y, et al. Cytochrome P450 3A4*22, PPAR-α, and ARNT polymorphisms and clopidogrel response. Clin Pharmacol. 2013;5:185-192. Published 2013 Dec 9. doi:10.2147/CPAA.S53151
Landry K. Kamdem, PhD
Kamdem, L. K., Liu, Y., Stearns, V., Kadlubar, S. A., Ramirez, J., Jeter, S., Shahverdi, K., Ward, B. A., Ogburn, E., Ratain, M. J., Flockhart, D. A., & Desta, Z. (2010). In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. British journal of clinical pharmacology, 70(6), 854–869. https://doi.org/10.1111/j.1365-2125.2010.03791.x
Kamdem, L. K., Flockhart, D. A., & Desta, Z. (2011). In vitro cytochrome P450-mediated metabolism of exemestane. Drug metabolism and disposition: the biological fate of chemicals, 39(1), 98–105. https://doi.org/10.1124/dmd.110.032276
Kamdem, L. K., Xi, J., Clark, B. L., Gregory, B. J., Kidwell, K. M., Storniolo, A. M., Stearns, V., Hayes, D. F., Gersch, C. L., Rae, J. M., Henry, N. L., & Hertz, D. L. (2019). Exemestane may be less detrimental than letrozole to bone health in women homozygous for the UGT2B17*2 gene deletion. Breast cancer research and treatment, 175(2), 297–303. https://doi.org/10.1007/s10549-019-05158-3
Desta, Z., Kreutz, Y., Nguyen, A. T., Li, L., Skaar, T., Kamdem, L. K., Henry, N. L., Hayes, D. F., Storniolo, A. M., Stearns, V., Hoffmann, E., Tyndale, R. F., & Flockhart, D. A. (2011). Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age. Clinical pharmacology and therapeutics, 90(5), 693–700. https://doi.org/10.1038/clpt.2011.174
Murugesh Kandasamy, PhD
No current publications.
Sri Harsha Kanuri, MD, PhD, MPH
, Chapman AB. Pharmacogenomic studies of hypertension: paving the way for personalized antihypertensive treatment. Expert Rev Precis Med Drug Dev. 2018;3(1):33-47. doi: 10.1080/23808993.2018.1420419. Epub 2018 Jan 3. PMID: 29888336; PMCID: PMC5990020.Kanuri SHEadon MT,
, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med. 2019 Mar;21(3):743-747. doi: 10.1038/s41436-018-0080-y. Epub 2018 Jul 12. Erratum in: Genet Med. 2018 Aug 29; Erratum in: Genet Med. 2020 Oct;22(10):1730. Erratum in: Genet Med. 2021 Oct;23(10):2020. PMID: 29997387; PMCID: PMC6330142.Kanuri SHLevy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM,
Kanuri SH, Ipe J, Kassab K, Gao H, Liu Y, Skaar TC, Kreutz RP. Next generation MicroRNA sequencing to identify coronary artery disease patients at risk of recurrent myocardial infarction. Atherosclerosis. 2018 Nov;278:232-239. doi: 10.1016/j.atherosclerosis.2018.09.021. Epub 2018 Oct 3. PMID: 30336307; PMCID: PMC6350783.
, Kreutz RP. Pharmacogenomics of Novel Direct Oral Anticoagulants: Newly Identified Genes and Genetic Variants. J Pers Med. 2019 Jan 17;9(1):7. doi: 10.3390/jpm9010007. PMID: 30658513; PMCID: PMC6463033.Kanuri SH
, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med. 2019 Jul;21(7):1670. doi: 10.1038/s41436-018-0280-5. Erratum for: Genet Med. 2019 Mar;21(3):743-747. PMID: 30158693; PMCID: PMC6752260.Kanuri SHLevy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM,
, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med. 2020 Oct;22(10):1730. doi: 10.1038/s41436-020-0911-5. Erratum for: Genet Med. 2019 Mar;21(3):743-747. PMID: 32719393; PMCID: PMC7521989.Kanuri SHLevy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM,
, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med. 2021 Oct;23(10):2020. doi: 10.1038/s41436-020-01054-0. Erratum for: Genet Med. 2019 Mar;21(3):743-747. PMID: 33288881; PMCID: PMC8486650.Kanuri SHLevy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM,
Kye-Min Kim, PhD
TBA.
Yangweon Kim, MD, PhD
TBA.
Lindsey Kirkpatrick, DO, PhD
Bhumbra, S., Malin, S., Kirkpatrick, L., Khaitan, A., John, C. C., Rowan, C. M., & Enane, L. A. (2020). Clinical Features of Critical Coronavirus Disease 2019 in Children. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 21(10), e948–e953. https://doi.org/10.1097/PCC.0000000000002511
Skaggs, C., Kirkpatrick, L., Wichert, W. R. A., Skaggs, N., & Manicke, N. E. (2020). A statistical approach to optimizing paper spray mass spectrometry parameters. Rapid communications in mass spectrometry : RCM, 34(7), e8601. https://doi.org/10.1002/rcm.8601
Skaggs, C. L., Ren, G. J., Elgierari, E. T. M., Sturmer, L. R., Shi, R. Z., Manicke, N. E., & Kirkpatrick, L. M. (2020). Simultaneous quantitation of five triazole anti-fungal agents by paper spray-mass spectrometry. Clinical chemistry and laboratory medicine, 58(5), 836–846. https://doi.org/10.1515/cclm-2019-0895
Skaggs, C., Zimmerman, H., Manicke, N., & Kirkpatrick, L. (2022). Development and validation of a paper spray mass spectrometry method for the rapid quantitation of remdesivir and its active metabolite, GS-441524, in human plasma. Journal of mass spectrometry and advances in the clinical lab, 25, 27–35. https://doi.org/10.1016/j.jmsacl.2022.06.001
Milton, J. R., Jankiewicz, B. J., Max, J. P., Vinueza, N. R., Kirkpatrick, L. M., Campbell, K., Gallardo, V. A., Reece, J. N., & Kenttämaa, H. I. (2021). Study on the Gas-Phase Reactivity of Charged Pyridynes. The Journal of organic chemistry, 86(15), 9979–9993. https://doi.org/10.1021/acs.joc.1c00618
Povilaitis, S. C., Chakraborty, A., Kirkpatrick, L. M., Downey, R. D., Hauger, S. B., & Eberlin, L. S. (2022). Identifying Clinically Relevant Bacteria Directly from Culture and Clinical Samples with a Handheld Mass Spectrometry Probe. Clinical chemistry, 68(11), 1459–1470. https://doi.org/10.1093/clinchem/hvac147
Bell, L. A., Tyler, C. P., Russell, M. R., Szoko, N., Harrison, E. I., Kazmerski, T. M., Syed, T., & Kirkpatrick, L. (2023). Preferences and Experiences Regarding Pregnancy Options Counseling in Adolescence and Young Adulthood: A Qualitative Study. The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 73(1), 164–171. https://doi.org/10.1016/j.jadohealth.2023.02.017
Kirkpatrick, L., Bell, L., Tyler, C. P., Harrison, E., Russell, M., Syed, T., Szoko, N., & Kazmerski, T. M. (2023). Health Care and Adoption Service Experiences of People Who Placed Children for Adoption During Adolescence: A Qualitative Study. Journal of pediatric and adolescent gynecology, 36(1), 58–64. https://doi.org/10.1016/j.jpag.2022.08.006
Bryan, A., Kirkpatrick, L. M., Manaloor, J. J., & Salipante, S. J. (2017). 16S rRNA deep sequencing identifies Actinotignum schaalii as the major component of a polymicrobial intra-abdominal infection and implicates a urinary source. JMM case reports, 4(5), e005091. https://doi.org/10.1099/jmmcr.0.005091
Girum L. Lemma, MD
Maayan Leroy-Melamed, MD, MPH*
Leroy-Melamed M, Katz A, Shew ML. Menstrual Dysfunction and Treatment Among Adolescents With Congenital Heart Disease. J Pediatr Adolesc Gynecol. 2020 Dec;33(6):686-690. doi: 10.1016/j.jpag.2020.08.012. Epub 2020 Aug 20. PMID: 32827759.
Leroy-Melamed M, Zhao Q, Belmonte MA, Archer J, Peipert JF. Contraceptive Preference, Continuation Rates, and Unintended Pregnancies in Patients with Comorbidities: A Prospective Cohort Study. J Womens Health (Larchmt). 2021 Oct;30(10):1469-1475. doi: 10.1089/jwh.2020.8536. Epub 2021 Jan 6. PMID: 33404367; PMCID: PMC8590153.
, Jacob S, Shew ML, Kazmerski TM. Provider Attitudes, Preferences, and Practices Regarding Sexual and Reproductive Health for Adolescents and Young Adults With Sickle Cell Disease. J Adolesc Health. 2021 Dec;69(6):970-975. doi: 10.1016/j.jadohealth.2021.06.008. Epub 2021 Jul 20. PMID: 34294508; PMCID: PMC8612941.Leroy-Melamed M
Youngchai Lim, PhD
Stephanie Liu, PharmD*
, Collins KS, Desta Z, Gufford BT, Eadon MT. Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness. J Nurse Pract. 2018 Nov-Dec;14(10):697-704.e1. doi: 10.1016/j.nurpra.2018.09.021. Epub 2018 Nov 2. PMID: 30555285; PMCID: PMC6291225. Liu SNFulton CR, Swart M, De Luca T,
Liu SN, Lu JBL, Watson CJW, Lazarus P, Desta Z, Gufford BT. Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors. Drug Metab Dispos. 2019 May;47(5):535-544. doi: 10.1124/dmd.118.085035. Epub 2019 Feb 25. PMID: 30804050; PMCID: PMC6474910.
Liu SN, Desta Z, Gufford BT. Probenecid-Boosted Tenofovir: A Physiologically-Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis. CPT Pharmacometrics Syst Pharmacol. 2020 Jan;9(1):40-47. doi: 10.1002/psp4.12481. Epub 2019 Dec 23. PMID: 31749296; PMCID: PMC6966182.
Liu SN, Gufford BT, Lu JBL, Bushman LR, Anderson PL, Bergstrom RF, Desta Z, Gupta SK. Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis. Clin Pharmacol Ther. 2020 May;107(5):1200-1208. doi: 10.1002/cpt.1714. Epub 2019 Dec 31. PMID: 31675437; PMCID: PMC7703849.
Deshun Lu, PhD*
Kreutz RP, Breall JA, Kreutz Y, Owens J, Lu D, Bolad I, von der Lohe E, Sinha A, Flockhart DA. Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependent on clopidogrel response. Thromb Res. 2012 Aug. PMID: 22459907. PMCID: PMC3965578.
Kreutz RP, Owens J, Breall JA, Lu D, von der Lohe E, Bolad I, Sinha A, Flockhart DA. C-reactive protein and fibrin clot strength measured by thrombelastography after coronary stenting. 2013 Apr. PMID: 23429252. PMCID: PMC4028117.
Lv W, Liu J, Lu D, Flockhart DA, Cushman M. Synthesis of mixed (E, Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities. J Med Chem. 2013 Jun. PMID 23731360. PMCID: PMC4043309.
Lu D, Owens J, Kreutz RP. Plasma and whole blood clot strength measured by thrombelastography in patients treated with clopidogrel during acute coronary syndromes. Thromb Res. 2013 Aug. PMID: 23920429. PMCID: PMC4028119.
Liu, J, Flockhart PJ, Lu D, Lv W, Lu WJ, Han x, Cushman M, Flockhart DA. Inhibition of cytochrome p450 enzymes by the e- and z-isomers of norendoxifen. Drug Metab Dispos. 2013 Sep. PMID: 23824607. PMCID: PMC3876808.
Reynold Ly, PhD
Aruldhas, B. W., Quinney, S. K., Overholser, B. R., Heathman, M. A., Masters, A. R., Ly, R. C., Gao, H., Packiasabapathy, S., & Sadhasivam, S. (2021). Pharmacokinetic modeling of R and S-Methadone and their metabolites to study the effects of various covariates in post-operative children. CPT: pharmacometrics & systems pharmacology, 10(10), 1183–1194. https://doi.org/10.1002/psp4.12687
Pratt, V. M., Cavallari, L. H., Fulmer, M. L., Gaedigk, A., Hachad, H., Ji, Y., Kalman, L. V., Ly, R. C., Moyer, A. M., Scott, S. A., van Schaik, R. H. N., Whirl-Carrillo, M., & Weck, K. E. (2022). TPMT and NUDT15 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase. The Journal of molecular diagnostics : JMD, 24(10), 1051–1063. https://doi.org/10.1016/j.jmoldx.2022.06.007
Rowe, E. J., Shugg, T., Ly, R. C., Philips, S., Rosenman, M. B., Callaghan, J. T., Radovich, M., Overholser, B. R., Schneider, B. P., Tisdale, J. E., & Skaar, T. C. (2022). Association of QT interval-prolonging drugs with clinical trial eligibility in patients with advanced cancer. Frontiers in cardiovascular medicine, 9, 894623. https://doi.org/10.3389/fcvm.2022.894623
Pratt, V. M., Cavallari, L. H., Del Tredici, A. L., Gaedigk, A., Hachad, H., Ji, Y., Kalman, L. V., Ly, R. C., Moyer, A. M., Scott, S. A., van Schaik, R. H. N., Whirl-Carrillo, M., & Weck, K. E. (2021). Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and the European Society for Pharmacogenomics and Personalized Therapy. The Journal of molecular diagnostics : JMD, 23(9), 1047–1064. https://doi.org/10.1016/j.jmoldx.2021.05.013
Shugg, T., Ly, R. C., Rowe, E. J., Philips, S., Hyder, M. A., Radovich, M., Rosenman, M. B., Pratt, V. M., Callaghan, J. T., Desta, Z., Schneider, B. P., & Skaar, T. C. (2022). Clinical Opportunities for Germline Pharmacogenetics and Management of Drug-Drug Interactions in Patients With Advanced Solid Cancers. JCO precision oncology, 6, e2100312. https://doi.org/10.1200/PO.21.00312
Powell, N. R., Shugg, T., Ly, R. C., Albany, C., Radovich, M., Schneider, B. P., & Skaar, T. C. (2022). Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report. Frontiers in oncology, 11, 809527. https://doi.org/10.3389/fonc.2021.809527
Ly, R. C., Shugg, T., Ratcliff, R., Osei, W., Lynnes, T. C., Pratt, V. M., Schneider, B. P., Radovich, M., Bray, S. M., Salisbury, B. A., Parikh, B., Sahinalp, S. C., Numanagić, I., & Skaar, T. C. (2022). Analytical Validation of a Computational Method for Pharmacogenetic Genotyping from Clinical Whole Exome Sequencing. The Journal of molecular diagnostics : JMD, 24(6), 576–585. https://doi.org/10.1016/j.jmoldx.2022.03.008
Ly, R. C., Schmidt, R. E., Kiel, P. J., Pratt, V. M., Schneider, B. P., Radovich, M., Offer, S. M., Diasio, R. B., & Skaar, T. C. (2020). Severe Capecitabine Toxicity Associated With a Rare DPYD Variant Identified Through Whole-Genome Sequencing. JCO precision oncology, 4, PO.20.00067. https://doi.org/10.1200/PO.20.00067
Shen, F., Jiang, G., Philips, S., Gardner, L., Xue, G., Cantor, E., Ly, R. C., Osei, W., Wu, X., Dang, C., Northfelt, D., Skaar, T., Miller, K. D., Sledge, G. W., & Schneider, B. P. (2023). Cytochrome P450 oxidoreductase, POR, associated with severe paclitaxel-induced peripheral neuropathy in patients of European ancestry from ECOG-ACRIN E5103. Clinical cancer research : an official journal of the American Association for Cancer Research, CCR-22-2431. Advance online publication. https://doi.org/10.1158/1078-0432.CCR-22-2431
Pratt, V. M., Cavallari, L. H., Del Tredici, A. L., Hachad, H., Ji, Y., Kalman, L. V., Ly, R. C., Moyer, A. M., Scott, S. A., Whirl-Carrillo, M., & Weck, K. E. (2020). Recommendations for Clinical Warfarin Genotyping Allele Selection: A Report of the Association for Molecular Pathology and the College of American Pathologists. The Journal of molecular diagnostics : JMD, 22(7), 847–859. https://doi.org/10.1016/j.jmoldx.2020.04.204
Gaedigk, A., Boone, E. C., Turner, A. J., van Schaik, R. H. N., Chernova, D., Wang, W. Y., Broeckel, U., Granfield, C. A., Hodge, J. C., Ly, R. C., Lynnes, T. C., Mitchell, M. W., Moyer, A. M., Oliva, J., & Kalman, L. V. (2023). Characterization of Reference Materials for CYP3A4 and CYP3A5: A GeT-RM Collaborative Project. The Journal of molecular diagnostics : JMD, S1525-1578(23)00133-2. Advance online publication. https://doi.org/10.1016/j.jmoldx.2023.06.005
Roth, A. M., Williams, J. A., Ly, R., Curd, K., Brooks, D., Arno, J., & Van Der Pol, B. (2011). Changing sexually transmitted infection screening protocol will result in improved case finding for trichomonas vaginalis among high-risk female populations. Sexually transmitted diseases, 38(5), 398–400. https://doi.org/10.1097/OLQ.0b013e318203e3ce
Srikar Malireddy, MD*
Tarunendu Mapder, PharmD*
Smitha Marri, MD*
Mwangi SM, Nezami BG, Obukwelu B, Anitha M, Marri S, Fu P, Epperson MF, Le NA, Shanmugam M, Sitaraman SV, Tseng YH, Anania FA, Srinivasan S. Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G515-25. doi: 10.1152/ajpgi.00364.2013. PMID: 24458024. PMCID: PMC3949027.
Harrison SA, Marri SR, Chalasani N, et al. Randomised clinical study: GR-MD-02, a galectin-3 inhibitor in patients having nonalcoholic steatohepatitis with advanced fibrosis. Aliment Pharmacol Ther. 2016 Dec;44(11-12):1183-1198. doi: 10.1111/apt.13816. Epub 2016 Oct 24. PMID: 27778367.
Emily Mason, PhD
Darius Meiman, PharmD*
Ingrid Ferreira Metzger, PhD
Metzger, I. F., Thomas, A. E., Evrard, C. A., Jones, D. R., Masters, A. R., Haas, D. M., Haneline, L. S., & Quinney, S. K. (2021). Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome. American journal of perinatology, 38(9), 968–975. https://doi.org/10.1055/s-0040-1701505
Gufford, B. T., Lu, J. B., Metzger, I. F., Jones, D. R., & Desta, Z. (2016). Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo. Drug metabolism and disposition: the biological fate of chemicals, 44(4), 544–553. https://doi.org/10.1124/dmd.115.068908
Masters, A. R., Gufford, B. T., Lu, J. B., Metzger, I. F., Jones, D. R., & Desta, Z. (2016). Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers. The Journal of pharmacology and experimental therapeutics, 358(2), 230–238. https://doi.org/10.1124/jpet.116.232876
Gufford, B. T., Metzger, I. F., Bamfo, N. O., Benson, E. A., Masters, A. R., Lu, J. B. L., & Desta, Z. (2022). Influence of CYP2B6 Pharmacogenetics on Stereoselective Inhibition and Induction of Bupropion Metabolism by Efavirenz in Healthy Volunteers. The Journal of pharmacology and experimental therapeutics, 382(3), 313–326. Advance online publication. https://doi.org/10.1124/jpet.122.001277
Onos, K. D., Quinney, S. K., Jones, D. R., Masters, A. R., Pandey, R., Keezer, K. J., Biesdorf, C., Metzger, I. F., Meyers, J. A., Peters, J., Persohn, S. C., McCarthy, B. P., Bedwell, A. A., Figueiredo, L. L., Cope, Z. A., Sasner, M., Howell, G. R., Williams, H. M., Oblak, A. L., Lamb, B. T., … Territo, P. R. (2022). Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study. Alzheimer's & dementia (New York, N. Y.), 8(1), e12329. https://doi.org/10.1002/trc2.12329
Ipe, J., Li, R., Metzger, I. F., Bo Li Lu, J., Gufford, B. T., Desta, Z., Liu, Y., & Skaar, T. C. (2021). Circulating miRNAs as Biomarkers for CYP2B6 Enzyme Activity. Clinical pharmacology and therapeutics, 109(2), 485–493. https://doi.org/10.1002/cpt.2018
Metzger, I. F., Quigg, T. C., Epstein, N., Aregbe, A. O., Thong, N., Callaghan, J. T., Flockhart, D. A., Nguyen, A. T., Stevens, C. K., Gupta, S. K., & Desta, Z. (2014). Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers. Current therapeutic research, clinical and experimental, 76, 64–69. https://doi.org/10.1016/j.curtheres.2014.05.002
Metzger, I. F., Dave, N., Kreutz, Y., Lu, J. B. L., Galinsky, R. E., & Desta, Z. (2019). CYP2B6 Genotype-Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers. Clinical and translational science, 12(6), 657–666. https://doi.org/10.1111/cts.12671
Collins, K. S., Metzger, I. F., Gufford, B. T., Lu, J. B., Medeiros, E. B., Pratt, V. M., Skaar, T. C., & Desta, Z. (2020). Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers. Drug metabolism and disposition: the biological fate of chemicals, 48(3), 169–175. https://doi.org/10.1124/dmd.119.089052
Robarge, J. D., Metzger, I. F., Lu, J., Thong, N., Skaar, T. C., Desta, Z., & Bies, R. R. (2016). Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition. Antimicrobial agents and chemotherapy, 61(1), e01813-16. https://doi.org/10.1128/AAC.01813-16
Desta, Z., Metzger, I. F., Thong, N., Lu, J. B., Callaghan, J. T., Skaar, T. C., Flockhart, D. A., & Galinsky, R. E. (2016). Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers. Antimicrobial agents and chemotherapy, 60(11), 6813–6822. https://doi.org/10.1128/AAC.01000-16
Burgess, K. S., Ipe, J., Swart, M., Metzger, I. F., Lu, J., Gufford, B. T., Thong, N., Desta, Z., Gaedigk, R., Pearce, R. E., Gaedigk, A., Liu, Y., & Skaar, T. C. (2018). Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs. Clinical pharmacology and therapeutics, 104(1), 130–138. https://doi.org/10.1002/cpt.892
Jia Miao, MD
Kreutz, R. P., Nystrom, P., Kreutz, Y., Miao, J., Desta, Z., Breall, J. A., Li, L., Chiang, C., Kovacs, R., Flockhart, D. A., & Jin, Y. (2012). Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response. Clinical pharmacology : advances and applications, 4, 13–20. https://doi.org/10.2147/CPAA.S27822
Kreutz, R. P., Nystrom, P., Kreutz, Y., Miao, J., Kovacs, R., Desta, Z., Flockhart, D. A., & Jin, Y. (2013). Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin. Platelets, 24(2), 145–150. https://doi.org/10.3109/09537104.2012.661107
Veronique Michaud, PhD, MSc
Michaud, V., Kreutz, Y., Skaar, T., Ogburn, E., Thong, N., Flockhart, D. A., & Desta, Z. (2014). Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent. The pharmacogenomics journal, 14(2), 151–159. https://doi.org/10.1038/tpj.2013.17
Michaud, V., Turgeon, J., Flockhart, D., & Wainberg, M. A. (2011). Rôle de la pharmacogénétique dans le métabolisme et le transport des antirétroviraux [Importance of pharmacogenetics in antiretroviral metabolism and drug-transporters]. Virologie (Montrouge, France), 15(3), 157–174. https://doi.org/10.1684/vir.2011.17135
Michaud, V., Ogburn, E., Thong, N., Aregbe, A. O., Quigg, T. C., Flockhart, D. A., & Desta, Z. (2012). Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers. Clinical pharmacology and therapeutics, 91(3), 475–482. https://doi.org/10.1038/clpt.2011.249
Jin, D., Wek, S. A., Cordova, R. A., Wek, R. C., Lacombe, D., Michaud, V., & Musier-Forsyth, K. (2023). Aminoacylation-defective bi-allelic mutations in human EPRS1 associated with psychomotor developmental delay, epilepsy, and deafness. Clinical genetics, 103(3), 358–363. https://doi.org/10.1111/cge.14269
Nick Miles, PharmD*
Kathleen A. Neville, MD
Nseobong Ntukidem, MD*
Aislinn O'Kane, PharmD*
No current publications.
Chimnonso Onuoha, PharmD*
, Fenn NE 3rd. Low-Molecular-Weight Heparin and Fondaparinux Use in Pediatric Patients With Obesity. Ann Pharmacother. 2021 May;55(5):666-676. doi: 10.1177/1060028020955029. Epub 2020 Aug 30. PMID: 32864984.Onuoha CPGarner MP,
Onuoha CP, Garner MP, Fenn NE 3rd. Student perceptions of co-curricular activities on pharmacy education: A review. Curr Pharm Teach Learn. 2021 May;13(5):576-584. doi: 10.1016/j.cptl.2021.01.017. Epub 2021 Feb 24. PMID: 33795114.
Rebecca Pierson, MD*
Pierson RC, Malone AM, Haas DM. Increasing Influenza Vaccination Rates in a Busy Urban Clinic. J Nat Sci. 2015;1(3):e57. PMID: 25750936; PMCID: PMC4347981.
Amar Pinto, MD
Liangpunsakul, S., Kolwankar, D., Pinto, A., Gorski, J. C., Hall, S. D., & Chalasani, N. (2005). Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics. Hepatology (Baltimore, Md.), 41(5), 1144–1150. https://doi.org/10.1002/hep.20673
Ho, H., Pinto, A., Hall, S. D., Flockhart, D. A., Li, L., Skaar, T. C., Cadman, P., O'Connor, D. T., Wagner, U., Fineberg, N. S., & Weinberger, M. H. (2005). Association between the CYP3A5 genotype and blood pressure. Hypertension (Dallas, Tex. : 1979), 45(2), 294–298. https://doi.org/10.1161/01.HYP.0000151361.31736.96
Gorski, J. C., Huang, S. M., Pinto, A., Hamman, M. A., Hilligoss, J. K., Zaheer, N. A., Desai, M., Miller, M., & Hall, S. D. (2004). The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clinical pharmacology and therapeutics, 75(1), 89–100. https://doi.org/10.1016/j.clpt.2003.09.013
Pinto, A. G., Wang, Y. H., Chalasani, N., Skaar, T., Kolwankar, D., Gorski, J. C., Liangpunsakul, S., Hamman, M. A., Arefayene, M., & Hall, S. D. (2005). Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression. Clinical pharmacology and therapeutics, 77(3), 178–188. https://doi.org/10.1016/j.clpt.2004.10.002
Adigun, A. Q., Pinto, A. G., Flockhart, D. A., Gorski, J. C., Li, L., Hall, S. D., & Chalasani, N. (2005). Effect of cirrhosis and liver transplantation on the gender difference in QT interval. The American journal of cardiology, 95(5), 691–694. https://doi.org/10.1016/j.amjcard.2004.10.054
Pinto, A. G., Horlander, J., Chalasani, N., Hamman, M., Asghar, A., Kolwankar, D., & Hall, S. D. (2005). Diltiazem inhibits human intestinal cytochrome P450 3A (CYP3A) activity in vivo without altering the expression of intestinal mRNA or protein. British journal of clinical pharmacology, 59(4), 440–446. https://doi.org/10.1111/j.1365-2125.2005.02343.x
Malireddy, S. R., Pinto, A. G., Chalasani, N. P., Gorski, J. C., & Hall, S. D. (2008). Altered first-pass effects in a liver transplant recipient explained intraindividual variation in calcineurin inhibitor concentrations: a case report. Transplantation proceedings, 40(5), 1789–1791. https://doi.org/10.1016/j.transproceed.2008.02.073
Pinto, A. G., Namyslowski, J., & Pandya, P. (2005). Severe thrombocytopenia due to hypersplenism successfully treated with partial splenic embolization in preoperative management. Southern medical journal, 98(4), 481–483. https://doi.org/10.1097/01.SMJ.0000157558.62378.0B
Chalasani, N., Kahi, C., Francois, F., Pinto, A., Marathe, A., Bini, E. J., Pandya, P., Sitaraman, S., & Shen, J. (2003). Improved patient survival after acute variceal bleeding: a multicenter, cohort study. The American journal of gastroenterology, 98(3), 653–659. https://doi.org/10.1111/j.1572-0241.2003.07294.x
Jagdeep (JD) Podichetty, PhD
Nick Powell, PharmD*
Troy Quigg, MD*
Metzger IF, Quigg TC, Epstein N, Aregbe AO, Thong N, Callaghan JT, Flockhart DA, Nguyen AT, Stevens CK, Gupta SK, Desta Z. Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers. Curr Ther Res Clin Exp. 2014 Sep 27;76:64-9. doi: 10.1016/j.curtheres.2014.05.002. PMID: 25352936; PMCID: PMC4209507.
Sara Quinney, PharmD, PhD*
Shanks AL, Grasch JL, Quinney SK, Haas DM. Controversies in antenatal corticosteroids. Semin Fetal Neonatal Med. 2019 Jun;24(3):182-188. doi: 10.1016/j.siny.2019.05.002. Epub 2019 May 29. PMID: 31155465 Review.
Quinney SK, Bonate PL. A pharmacometrician's role in enhancing medication use in pregnancy and lactation. J Pharmacokinet Pharmacodyn. 2020 Aug;47(4):267-269. doi: 10.1007/s10928-020-09707-y. PMID: 32803462 Free PMC article. No abstract available.
Aruldhas BW, Quinney SK, Overholser BR, Heathman MA, Masters AR, Ly RC, Gao H, Packiasabapathy S, Sadhasivam S. Pharmacokinetic modeling of R and S-Methadone and their metabolites to study the effects of various covariates in post-operative children. CPT Pharmacometrics Syst Pharmacol. 2021 Oct;10(10):1183-1194. doi: 10.1002/psp4.12687. Epub 2021 Aug 26. PMID: 34435753 Free PMC article.
Packiasabapathy S, Aruldhas BW, Horn N, Overholser BR, Quinney SK, Renschler JS, Sadhasivam S. Pharmacogenomics of methadone: a narrative review of the literature. Pharmacogenomics. 2020 Aug;21(12):871-887. doi: 10.2217/pgs-2020-0040. Epub 2020 Jul 24. PMID: 32705966 Free PMC article. Review.
Wu HY, Shendre A, Zhang S, Zhang P, Wang L, Zeruesenay D, Rocha LM, Shatkay H, Quinney SK, Ning X, Li L. Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics. Clin Pharmacol Ther. 2020 Apr;107(4):886-902. doi: 10.1002/cpt.1745. Epub 2020 Feb 3. PMID: 31863452 Free PMC article. Review.
Liao MZ, Flood Nichols SK, Ahmed M, Clark S, Hankins GD, Caritis S, Venkataramanan R, Haas D, Quinney SK, Haneline LS, Tita AT, Manuck T, Wang J, Thummel KE, Brown LM, Ren Z, Easterling TR, Hebert MF. Effects of Pregnancy on the Pharmacokinetics of Metformin. Drug Metab Dispos. 2020 Apr;48(4):264-271. doi: 10.1124/dmd.119.088435. Epub 2020 Jan 24. PMID: 31980499 Free PMC article. Clinical Trial.
Quinney SK, Gullapelli R, Haas DM. Translational Systems Pharmacology Studies in Pregnant Women. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):69-81. doi: 10.1002/psp4.12269. Epub 2017 Dec 14. PMID: 29239132 Free PMC article. Review.
Metzger IF, Thomas AE, Evrard CA, Jones DR, Masters AR, Haas DM, Haneline LS, Quinney SK. Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome. Am J Perinatol. 2021 Jul;38(9):968-975. doi: 10.1055/s-0040-1701505. Epub 2020 Feb 12. PMID: 32052397
Quinney SK, Patil AS, Flockhart DA. Is personalized medicine achievable in obstetrics? Semin Perinatol. 2014 Dec;38(8):534-40. doi: 10.1053/j.semperi.2014.08.017. Epub 2014 Oct 3. PMID: 25282474 Free PMC article. Review.
Sorkin BC, Kuszak AJ, Bloss G, Fukagawa NK, Hoffman FA, Jafari M, Barrett B, Brown PN, Bushman FD, Casper SJ, Chilton FH, Coffey CS, Ferruzzi MG, Hopp DC, Kiely M, Lakens D, MacMillan JB, Meltzer DO, Pahor M, Paul J, Pritchett-Corning K, Quinney SK, Rehermann B, Setchell KDR, Sipes NS, Stephens JM, Taylor DL, Tiriac H, Walters MA, Xi D, Zappalá G, Pauli GF. Improving natural product research translation: From source to clinical trial. FASEB J. 2020 Jan;34(1):41-65. doi: 10.1096/fj.201902143R. Epub 2019 Dec 10. PMID: 31914647 Free PMC article.
Marks C, Silvola R, Teal E, Quinney SK, Haas DM. Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study. Pharmacotherapy. 2021 Nov;41(11):907-914. doi: 10.1002/phar.2628. Epub 2021 Oct 26. PMID: 34587291
Sukoff Rizzo SJ, Masters A, Onos KD, Quinney S, Sasner M, Oblak A, Lamb BT, Territo PR; MODEL‐AD consortium. Improving preclinical to clinical translation in Alzheimer's disease research. Alzheimers Dement (N Y). 2020 Jun 14;6(1):e12038. doi: 10.1002/trc2.12038. eCollection 2020. PMID: 32548237 Free PMC article.
McKinzie AH, Yang Z, Teal E, Daggy JK, Tepper RS, Quinney SK, Rhoads E, Haneline LS, Haas DM. Are newborn outcomes different for term babies who were exposed to antenatal corticosteroids? Am J Obstet Gynecol. 2021 Nov;225(5):536.e1-536.e7. doi: 10.1016/j.ajog.2021.04.251. Epub 2021 May 3. PMID: 33957112
Yao X, Tsang T, Sun Q, Quinney S, Zhang P, Ning X, Li L, Shen L. Mining and visualizing high-order directional drug interaction effects using the FAERS database. BMC Med Inform Decis Mak. 2020 Mar 18;20(Suppl 2):50. doi: 10.1186/s12911-020-1053-z. PMID: 32183790 Free PMC article.
Packiasabapathy S, Aruldhas BW, Zhang P, Overholser BR, Quinney SK, Sadhasivam S. Novel associations between CYP2B6 polymorphisms, perioperative methadone metabolism and clinical outcomes in children. Pharmacogenomics. 2021 Jul;22(10):591-602. doi: 10.2217/pgs-2021-0039. Epub 2021 Jun 8. PMID: 34100292 Free PMC article.
Zhang P, Wu HY, Chiang CW, Wang L, Binkheder S, Wang X, Zeng D, Quinney SK, Li L. Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):90-102. doi: 10.1002/psp4.12267. Epub 2018 Jan 9. PMID: 29193890 Free PMC article. Review.
Quinney SK, Benjamin T, Zheng X, Patil AS. Characterization of Maternal and Fetal CYP3A-Mediated Progesterone Metabolism. Fetal Pediatr Pathol. 2017 Oct;36(5):400-411. doi:10.1080/15513815.2017.1354411. Epub 2017 Sep 26.PMID: 28949811 Free PMC article.
Kinney MT, Quinney SK, Trussell HK, Silva LL, Ibrahim SA, Haas DM. Do maternal demographics and prenatal history impact the efficacy of betamethasone therapy for threatened preterm labor? BMC Pregnancy Childbirth. 2021 Jun 24;21(1):442. doi: 10.1186/s12884-021-03949-5. PMID: 34167497 Free PMC article.
Sadhasivam S, Aruldhas BW, Packiasabapathy S, Overholser BR, Zhang P, Zang Y, Renschler JS, Fitzgerald RE, Quinney SK. A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects. Anesth Analg. 2021 Aug 1;133(2):327-337. doi:10.1213/ANE.0000000000005366.PMID: 33481403 Free PMC article. Clinical Trial.
Caan BJ, Meyerhardt JA, Brown JC, Campbell KL, Cespedes Feliciano EM, Lee C, Ross MC, Quinney S, Quesenberry C, Sternfeld B, Schmitz KH. Recruitment strategies and design considerations in a trial of resistance training to prevent dose-limiting toxicities in colon cancer patients undergoing chemotherapy. Contemp Clin Trials. 2021 Feb;101:106242. doi: 10.1016/j.cct.2020.106242. Epub 2020 Dec 7. PMID: 33301991 Free PMC article. Clinical Trial.
Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Brown LM, Ren Z, Brown Z, Easterling TR, Hebert MF. Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus.Clin Pharmacol Ther. 2020 Jun;107(6):1362-1372. doi: 10.1002/cpt.1749. Epub 2020 Jan 25.PMID: 31869430 Free PMC article. Clinical Trial.
Haas DM, Benjamin T, Sawyer R, Quinney SK. Short-term tocolytics for preterm delivery - current perspectives.Int J Womens Health. 2014 Mar 27;6:343-9. doi: 10.2147/IJWH.S44048. eCollection 2014. PMID: 24707187 Free PMC article. Review.
Hua L, Chiang CW, Cong W, Li J, Wang X, Cheng L, Feng W, Quinney SK, Wang L, Li L. The Cancer Drug Fraction of Metabolism Database. CPT Pharmacometrics Syst Pharmacol. 2019 Jul;8(7):511-519. doi: 10.1002/psp4.12417. Epub 2019 Jun 17. PMID: 31206254 Free PMC article.
Wang X, Zhang P, Chiang CW, Wu H, Shen L, Ning X, Zeng D, Wang L, Quinney SK, Feng W, Li L. Mixture drug-count response model for the high-dimensional drug combinatory effect on myopathy. Stat Med. 2018 Feb 20;37(4):673-686. doi: 10.1002/sim.7545. Epub 2017 Nov 23. PMID: 29171062 Free PMC article.
McDowell ML, Tonismae TR, Slaven JE, Abernathy MP, Shanks AL, Benjamin TD, Quinney SK. The Impact of Hepatitis C Virus Infection on Buprenorphine Dose in Pregnancy. Am J Perinatol. 2020 Jan;37(1):73-78. doi: 10.1055/s-0039-1698838. Epub 2019 Oct 26. PMID: 31655490
Quinney SK, Haehner BD, Rhoades MB, Lin Z, Gorski JC, Hall SD. Interaction between midazolam and clarithromycin in the elderly. Br J Clin Pharmacol. 2008 Jan;65(1):98-109. doi: 10.1111/j.1365-2125.2007.02970.x. Epub 2007 Jul 17. PMID: 17635500 Free PMC article. Clinical Trial.
Friedman AN, Considine RV, Quinney SK. Inquiry into the short- and long-term effects of Roux-en-Y gastric bypass on the glomerular filtration rate. Ren Fail. 2020 Nov;42(1):624-628. doi: 10.1080/0886022X.2020.1790389.PMID: 32654577 Free PMC article.
Wu HY, Karnik S, Subhadarshini A, Wang Z, Philips S, Han X, Chiang C, Liu L, Boustani M, Rocha LM, Quinney SK, Flockhart D, Li L. An integrated pharmacokinetics ontology and corpus for text mining.BMC Bioinformatics. 2013 Feb 1;14:35. doi: 10.1186/1471-2105-14-35.PMID: 23374886 Free PMC article.
Friedman AN, Moe S, Fadel WF, Inman M, Mattar SG, Shihabi Z, Quinney SK. Predicting the glomerular filtration rate in bariatric surgery patients. Am J Nephrol. 2014;39(1):8-15. doi: 10.1159/000357231. Epub 2013 Dec 19. PMID: 24356416 Free PMC article.
Wu HY, Lu D, Hyder M, Zhang S, Quinney SK, Desta Z, Li L. DrugMetab: An Integrated Machine Learning and Lexicon Mapping Named Entity Recognition Method for Drug Metabolite. CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):709-717. doi: 10.1002/psp4.12340. Epub 2018 Sep 29. PMID: 30033622 Free PMC article.
Chiang CW, Zhang P, Wang X, Wang L, Zhang S, Ning X, Shen L, Quinney SK, Li L. Translational High-Dimensional Drug Interaction Discovery and Validation Using Health Record Databases and Pharmacokinetics Models. Clin Pharmacol Ther. 2018 Feb;103(2):287-295. doi: 10.1002/cpt.914. Epub 2017 Dec 11. PMID: 29052226
Miao J, Jin Y, Marunde RL, Gorski CJ, Kim S, Quinney S, Radovich M, Li L, Hall SD. Association of genotypes of the CYP3A cluster with midazolam disposition in vivo. Pharmacogenomics J. 2009 Oct;9(5):319-26. doi: 10.1038/tpj.2009.21. Epub 2009 Jun 9. PMID: 19506580 Free PMC article.
Quinney SK, Malireddy SR, Vuppalanchi R, Hamman MA, Chalasani N, Gorski JC, Hall SD. Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin. Eur J Clin Pharmacol. 2013 Mar;69(3):439-48. doi: 10.1007/s00228-012-1339-x. Epub 2012 Jul 10. PMID: 22777148 Free PMC article. Clinical Trial.
Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Morris Brown L, Ren Z, Brown Z, Easterling TR, Hebert MF. Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus. J Clin Pharmacol. 2020 Apr;60(4):540-549. doi: 10.1002/jcph.1549. Epub 2019 Nov 19. PMID: 31742716 Free PMC article. Clinical Trial.
Oblak AL, Cope ZA, Quinney SK, Pandey RS, Biesdorf C, Masters AR, Onos KD, Haynes L, Keezer KJ, Meyer JA, Peters JS, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Little G, Williams SP, Noarbe B, Obenaus A, Sasner M, Howell GR, Carter GW, Williams H, Lamb BT, Territo PR, Sukoff Rizzo SJ. Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice. Alzheimers Dement (N Y). 2022 Jul 14;8(1):e12317. doi: 10.1002/trc2.12317. eCollection 2022. PMID: 35846156 Free PMC article.
Dorr ML, Pierson RC, Daggy J, Quinney SK, Haas DM. Buccal versus Vaginal Misoprostol for Term Induction of Labor: A Retrospective Cohort Study. Am J Perinatol. 2019 Jun;36(7):765-772. doi: 10.1055/s-0038-1675219. Epub 2018 Oct 31. PMID: 30380580 Free PMC article.
Podichetty JT, Brinda BJ, Nelson RP, Karr AH, Prasad NK, Quinney S, Foxworthy Scott S, Kiel PJ. Pharmacokinetics of Basiliximab for the Prevention of Graft-versus-Host Disease in Patients Undergoing Hematopoietic Cell Transplantation with Minimal-Intensity Cyclophosphamide and Fludarabine. Pharmacotherapy. 2020 Jan;40(1):26-32. doi: 10.1002/phar.2347. Epub 2019 Dec 20. PMID: 31742732 Clinical Trial.
Quinney SK. Opportunities and Challenges of Using Big Data to Detect Drug-Drug Interaction Risk. Clin Pharmacol Ther. 2019 Jul;106(1):72-74. doi: 10.1002/cpt.1481. Epub 2019 Jun 11. PMID: 31184772 Free PMC article. No abstract available.
Haas DM, Daggy J, Flannery KM, Dorr ML, Bonsack C, Bhamidipalli SS, Pierson RC, Lathrop A, Towns R, Ngo N, Head A, Morgan S, Quinney SK. A comparison of vaginal versus buccal misoprostol for cervical ripening in women for labor induction at term (the IMPROVE trial): a triple-masked randomized controlled trial. Am J Obstet Gynecol. 2019 Sep;221(3):259.e1-259.e16. doi: 10.1016/j.ajog.2019.04.037. Epub 2019 May 7. PMID: 31075246 Free PMC article. Clinical Trial.
Zhang X, Galinsky RE, Kimura RE, Quinney SK, Jones DR, Hall SD. Inhibition of CYP3A by erythromycin: in vitro-in vivo correlation in rats. Drug Metab Dispos. 2010 Jan;38(1):61-72. doi: 0.1124/dmd.109.028290. PMID: 19797607
Haas DM, Quinney SK, Clay JM, Renbarger JL, Hebert MF, Clark S, Umans JG, Caritis SN; Obstetric-Fetal Pharmacology Research Units Network. Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic. Am J Perinatol. 2013 Apr;30(4):275-81. doi: 10.1055/s-0032-1323590. Epub 2012 Aug 8. PMID: 22875663 Free PMC article.
Quinney SK, Zhang X, Lucksiri A, Gorski JC, Li L, Hall SD. Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin. Drug Metab Dispos. 2010 Feb;38(2):241-8. doi: 10.1124/dmd.109.028746. Epub 2009 Nov 2. PMID: 19884323 Free PMC article.
Silva LL, Silvola RM, Haas DM, Quinney SK. Physiologically based pharmacokinetic modelling in pregnancy: Model reproducibility and external validation. Br J Clin Pharmacol. 2022 Feb;88(4):1441-1451. doi: 10.1111/bcp.15018. Epub 2021 Aug 26. PMID: 34337764
Blue EK, Ballman K, Boyle F, Oh E, Kono T, Quinney SK, Thurmond DC, Evans-Molina C, Haneline LS. Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats. Pediatr Res. 2015 Feb;77(2):316-25. doi: 10.1038/pr.2014.185. Epub 2014 Nov 20. PMID: 25412163 Free PMC article.
Zhang P, Li M, Chiang CW, Wang L, Xiang Y, Cheng L, Feng W, Schleyer TK, Quinney SK, Wu HY, Zeng D, Li L. Three-Component Mixture Model-Based Adverse Drug Event Signal Detection for the Adverse Event Reporting System. CPT Pharmacometrics Syst Pharmacol. 2018 Aug;7(8):499-506. doi:0.1002/psp4.12294. Epub 2018 Aug 9. PMID: 30091855 Free PMC article.
Zhang X, Quinney SK, Gorski JC, Jones DR, Hall SD. Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite. Drug Metab Dispos. 2009 Aug;37(8):1587-97. doi: 10.1124/dmd.109.026658. Epub 2009 May 6. PMID: 19420129 Clinical Trial.
Friedman AN, Strother M, Quinney SK, Hall S, Perkins SM, Brizendine EJ, Inman M, Gomez G, Shihabi Z, Moe S, Li L. Measuring the glomerular filtration rate in obese individuals without overt kidney disease. Nephron Clin Pract. 2010;116(3):c224-34. doi: 10.1159/000317203. Epub 2010 Jul 2. PMID: 20606483 Free PMC article. Clinical Trial.
Binkheder S, Wu HY, Quinney SK, Zhang S, Zitu MM, Chiang CW, Wang L, Jones J, Li L. PhenoDEF: a corpus for annotating sentences with information of phenotype definitions in biomedical literature. J Biomed Semantics. 2022 Jun 11;13(1):17. doi: 10.1186/s13326-022-00272-6. PMID: 35690873 Free PMC article.
Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11. doi: 10.1124/dmd.32.5.505. PMID: 15100172
Towns R, Quinney SK, Pierson RC, Haas DM. Survey of Provider Preferences Regarding the Route of Misoprostol for Induction of Labor at Term. AJP Rep. 2017 Jul;7(3):e158-e162. doi: 10.1055/s-0037-1603954. Epub 2017 Jul 25. PMID: 28752015 Free PMC article.
Duke JD, Han X, Wang Z, Subhadarshini A, Karnik SD, Li X, Hall SD, Jin Y, Callaghan JT, Overhage MJ, Flockhart DA, Strother RM, Quinney SK, Li L. Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions. PLoS Comput Biol. 2012;8(8):e1002614. doi: 10.1371/journal.pcbi.1002614. Epub 2012 Aug 9. PMID: 22912565 Free PMC article.
Han X, Quinney SK, Wang Z, Zhang P, Duke J, Desta Z, Elmendorf JS, Flockhart DA, Li L. Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach. Clin Pharmacol Ther. 2015 Sep;98(3):321-7. doi: 10.1002/cpt.150. PMID: 25975815 Free PMC article.
Friedman AN, Quinney SK, Inman M, Mattar SG, Shihabi Z, Moe S. Influence of dietary protein on glomerular filtration before and after bariatric surgery: a cohort study. Am J Kidney Dis. 2014 Apr;63(4):598-603. doi: 10.1053/j.ajkd.2013.11.012. Epub 2013 Dec 31. PMID: 24387796 Free PMC article.
Friedman AN, Yu Z, Juliar BE, Nguyen JT, Strother M, Quinney SK, Li L, Inman M, Gomez G, Shihabi Z, Moe S. Independent influence of dietary protein on markers of kidney function and disease in obesity. Kidney Int. 2010 Oct;78(7):693-7. doi: 10.1038/ki.2010.184. Epub 2010 Jul 21. PMID: 20664561 Clinical Trial.
Blue EK, DiGiuseppe R, Derr-Yellin E, Acosta JC, Pay SL, Hanenberg H, Schellinger MM, Quinney SK, Mund JA, Case J, Haneline LS. Gestational diabetes induces alterations in the function of neonatal endothelial colony-forming cells. Pediatr Res. 2014 Feb;75(2):266-72. doi: 10.1038/pr.2013.224. Epub 2013 Nov 14. PMID: 24232636 Free PMC article.
Ferrari Gianlupi J, Mapder T, Sego TJ, Sluka JP, Quinney SK, Craig M, Stratford RE Jr, Glazier JA. Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2. Viruses. 2022 Mar 14;14(3):605. doi: 10.3390/v14030605. PMID: 35337012 Free PMC article.
Vorontsova Y, Haas DM, Flannery K, Masters AR, Silva LL, Pierson RC, Yeley B, Hogg G, Guise D, Heathman M, Quinney SK. Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term. Clin Transl Sci. 2022 May 19. doi: 10.1111/cts.13306. Online ahead of print. PMID: 35587540
Sanghani SP, Quinney SK, Fredenburg TB, Sun Z, Davis WI, Murry DJ, Cummings OW, Seitz DE, Bosron WF. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. Clin Cancer Res. 2003 Oct 15;9(13):4983-91. PMID: 14581373
Du L, Chakraborty A, Chiang CW, Cheng L, Quinney SK, Wu H, Zhang P, Li L, Shen L. Graphic Mining of High-Order Drug Interactions and Their Directional Effects on Myopathy Using Electronic Medical Records. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):481-8. doi: 10.1002/psp4.59. Epub 2015 Jul 6. PMID: 26380157 Free PMC article.
Egbelakin A, Ferguson MJ, MacGill EA, Lehmann AS, Topletz AR, Quinney SK, Li L, McCammack KC, Hall SD, Renbarger JL. Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011 Mar;56(3):361-7. doi: 10.1002/pbc.22845. Epub 2010 Nov 11. PMID: 21225912 Free PMC article.
Haas DM, Quinney SK, McCormick CL, Jones DR, Renbarger JL. A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic. J Matern Fetal Neonatal Med. 2012 Apr;25(4):419-23. doi: 10.3109/14767058.2011.583700. Epub 2011 Jun 7. PMID: 21644845 Clinical Trial.
Quinney SK, Galinsky RE, Jiyamapa-Serna VA, Chen Y, Hamman MA, Hall SD, Kimura RE. Hydroxyitraconazole, formed during intestinal first-pass metabolism of itraconazole, controls the time course of hepatic CYP3A inhibition and the bioavailability of itraconazole in rats. Drug Metab Dispos. 2008 Jun;36(6):1097-101. doi: 10.1124/dmd.108.020644. Epub 2008 Mar 13. PMID: 18339815
Wang L, Chiang C, Liang H, Wu H, Feng W, Quinney SK, Li J, Li L. How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective. Biomed Res Int. 2015;2015:857327. doi: 10.1155/2015/857327. Epub 2015 Oct 11. PMID: 26539530 Free PMC article.
Wang Z, Kim S, Quinney SK, Guo Y, Hall SD, Rocha LM, Li L. Literature mining on pharmacokinetics numerical data: a feasibility study. J Biomed Inform. 2009 Aug;42(4):726-35. doi: 10.1016/j.jbi.2009.03.010. Epub 2009 Apr 2. PMID: 19345282 Free PMC article.
Quinney SK, Knopp S, Chang C, Hall SD, Li L. Integration of in vitro binding mechanism into the semiphysiologically based pharmacokinetic interaction model between ketoconazole and midazolam. CPT Pharmacometrics Syst Pharmacol. 2013 Sep 11;2(9):e75. doi: 10.1038/psp.2013.50. PMID: 24448021 Free PMC article.
Xu C, Quinney SK, Guo Y, Hall SD, Li L, Desta Z. CYP2B6 pharmacogenetics-based in vitro-in vivo extrapolation of efavirenz clearance by physiologically based pharmacokinetic modeling. Drug Metab Dispos. 2013 Dec;41(12):2004-11. doi: 10.1124/dmd.113.051755. Epub 2013 Jul 11. PMID: 23846872 Free PMC article. Clinical Trial.
Zhang P, Du L, Wang L, Liu M, Cheng L, Chiang CW, Wu HY, Quinney SK, Shen L, Li L. A Mixture Dose-Response Model for Identifying High-Dimensional Drug Interaction Effects on Myopathy Using Electronic Medical Record Databases. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):474-80. doi: 10.1002/psp4.53. Epub 2015 Jul 6. PMID: 26380156 Free PMC article.
Quinney SK, Mohamed AN, Hebert MF, Haas DM, Clark S, Umans JG, Caritis SN, Li L. A Semi-Mechanistic Metabolism Model of CYP3A Substrates in Pregnancy: Predicting Changes in Midazolam and Nifedipine Pharmacokinetics. CPT Pharmacometrics Syst Pharmacol. 2012 Sep 26;1(9):e2. doi: 10.1038/psp.2012.5. PMID: 23835882 Free PMC article.
Nader AM, Quinney SK, Fadda HM, Foster DR. Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine. AAPS J. 2016 Jul;18(4):981-8. doi: 10.1208/s12248-016-9918-x. Epub 2016 Apr 22. PMID: 27106837 Free PMC article.
Wang Z, Kim S, Quinney SK, Zhou J, Li L. Non-compartment model to compartment model pharmacokinetics transformation meta-analysis--a multivariate nonlinear mixed model. BMC Syst Biol. 2010 May 28;4 Suppl 1(Suppl 1):S8. doi: 10.1186/1752-0509-4-S1-S8. PMID: 20522258 Free PMC article.
Osteen SJ, Yang Z, Mckinzie AH, Teal E, Tepper RS, Rhoads E, Quinney SK, Haneline LS, Haas DM. Long-term childhood outcomes for babies born at term who were exposed to antenatal corticosteroids. Am J Obstet Gynecol. 2022 Jul 21:S0002-9378(22)00580-4. doi: 10.1016/j.ajog.2022.07.026. Online ahead of print. PMID: 35872037
Binkheder S, Wu HY, Quinney SK, Zhang S, Zitu MM, Chiang CW, Wang L, Jones J, Li L. Correction: PhenoDEF: a corpus for annotating sentences with information of phenotype definitions in biomedical literature. J Biomed Semantics. 2022 Jul 20;13(1):20. doi: 10.1186/s13326-022-00275-3. PMID: 35858945 Free PMC article. No abstract available.
Amir Rashidian, PharmD, PhD
No current publications.
Anthony Raviele, PharmD*
Ashley Rawson, MD
Carpenter, C. P., Rawson, A., Hains, D. S., & Giel, D. W. (2018). Resolution of Diabetes Insipidus After Pyeloplasty: A Case Report and Review of the Literature. Urology, 115, 168–170. https://doi.org/10.1016/j.urology.2018.02.017
Rawson, A., Saxena, V., Gao, H., Hooks, J., Xuei, X., McGuire, P., Hato, T., Hains, D. S., Anderson, R. M., & Schwaderer, A. L. (2022). A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection. Pathogens & immunity, 7(1), 1–18. https://doi.org/10.20411/pai.v7i1.479
Hains, D. S., Polley, S., Liang, D., Saxena, V., Arregui, S., Ketz, J., Barr-Beare, E., Rawson, A., Spencer, J. D., Cohen, A., Hansen, P. L., Tuttolomondo, M., Casella, C., Ditzel, H. J., Cohen, D., Hollox, E. J., & Schwaderer, A. L. (2021). Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice. Clinical and translational medicine, 11(7), e477. https://doi.org/10.1002/ctm2.477
Rawson, A., Wilson, A. C., Schwaderer, A. L., Spiwak, E., Johnston, B., Anderson, S., Nailescu, C., Gupta, S., Christenson, J. C., Hains, D. S., & Starr, M. C. (2021). Coronavirus disease 2019 (COVID-19) in two pediatric patients with kidney disease on chronic immunosuppression: A case series. Hemodialysis international. International Symposium on Home Hemodialysis, 25(1), E1–E5. https://doi.org/10.1111/hdi.12876
Jason Robarge, PhD*
Eadon MT, Desta Z, Levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dave N, Robarge JD, Hyder MA, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clin Pharmacol Ther. 2016 Feb 6. doi:10.1002/cpt.347. [Epub ahead of print] Review. PMID: 26850569 PMCID: PMC4899152
Santa-Maria CA, Blackford A, Nguyen AT, Skaar TC, Philips S, Oesterreich S, Rae JM, Desta Z, Robarge J, Henry NL, Storniolo AM, Hayes DF, Blumenthal RS, Ouyang P, Post WS, Flockhart DA, Stearns V;. Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy. Clin Cancer Res 2016 Mar 15;22(6):1395-402. PMID: 26463708. PMCID: PMC4794377.
Robarge JD, Duarte DB, Shariati 3, Wang 4, Flockhart D5, Vasko MR. Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons. Exp Neural. 2016 April 9; 281: 53-65. PMID: 27072527. PMCID: PMC4877294.
Eadon MT, Desta Z, Levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dave N, Robarge JD, Hyder MA, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clin Pharmacol Ther. 2016 Jul;100(1):63-6. PMID: 26850569. PMCID: PMC4899152.
Abdelhady AM, Shugg T, Thong N, Lu JB, Kreutz Y, Jaynes HA, Robarge JD, Tisdale JE, Desta Z, Overholser BR. Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers. J Cardiovasc Electrophysiol. 2016 Oct;27(10):1206-1213Epub 2016 Jul 25. PMID: 27333947; PMCID: PMC5065384.
Robarge JD, Metzger IF, Lu J, Thong N, Skaar TC, Desta Z, Bies RR. Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition. Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01813-16PMID: 27799204; PMCID: PMC5192152.
Robarge JD, Desta Z, Nguyen AT, Li L, Hertz D, Rae JM, Hayes DF, Storniolo AM, Stearns V, Flockhart DA, Skaar TC, Henry NL. Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer. Breast Cancer Res Treat. 2017 Feb;161(3):453-461. Epub 2016 Dec 9. PMID: 27943008; PMCID: PMC5429096.
Violeta Rodriguez Romero, PhD
Rodriguez-Romero, V., Bergstrom, R. F., Decker, B. S., Lahu, G., Vakilynejad, M., & Bies, R. R. (2019). Prediction of Nephropathy in Type 2 Diabetes: An Analysis of the ACCORD Trial Applying Machine Learning Techniques. Clinical and translational science, 12(5), 519–528. https://doi.org/10.1111/cts.12647
Podichetty, J. T., Silvola, R. M., Rodriguez-Romero, V., Bergstrom, R. F., Vakilynejad, M., Bies, R. R., & Stratford, R. E., Jr (2021). Application of machine learning to predict reduction in total PANSS score and enrich enrollment in schizophrenia clinical trials. Clinical and translational science, 14(5), 1864–1874. https://doi.org/10.1111/cts.13035
Elizabeth Rowe, PhD
Oliver Schantz, MD
Anna Schwartz, MD
TBA.
Eric Sherer, PhD
Kahi, C. J., Myers, L. J., Stump, T. E., Imler, T. D., Sherer, E. A., Larson, J., & Imperiale, T. F. (2022). Tailoring Surveillance Colonoscopy in Patients With Advanced Adenomas. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 20(4), 847–854.e1. https://doi.org/10.1016/j.cgh.2021.03.027
Imperiale, T. F., Daggy, J. K., Imler, T. D., Sherer, E. A., Kahi, C. J., Larson, J., Cardwell, J., Johnson, C. S., Ahnen, D. J., Antaki, F., Ashley, C., Baffy, G., Dominitz, J. A., Hou, J., Korsten, M. A., Nagar, A., Promrat, K., Robertson, D. J., Saini, S., Shergill, A., … Smalley, W. E. (2021). Prevalence of Advanced Colorectal Neoplasia in Veterans: Effects of Age, Sex, and Race/Ethnicity. Journal of clinical gastroenterology, 55(10), 876–883. https://doi.org/10.1097/MCG.0000000000001402
Sherer, E. A., Sale, M. E., Pollock, B. G., Belani, C. P., Egorin, M. J., Ivy, P. S., Lieberman, J. A., Manuck, S. B., Marder, S. R., Muldoon, M. F., Scher, H. I., Solit, D. B., & Bies, R. R. (2012). Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building. Journal of pharmacokinetics and pharmacodynamics, 39(4), 393–414. https://doi.org/10.1007/s10928-012-9258-0
Imler, T. D., Morea, J., Kahi, C., Sherer, E. A., Cardwell, J., Johnson, C. S., Xu, H., Ahnen, D., Antaki, F., Ashley, C., Baffy, G., Cho, I., Dominitz, J., Hou, J., Korsten, M., Nagar, A., Promrat, K., Robertson, D., Saini, S., Shergill, A., … Imperiale, T. F. (2015). Multi-center colonoscopy quality measurement utilizing natural language processing. The American journal of gastroenterology, 110(4), 543–552. https://doi.org/10.1038/ajg.2015.51
Imperiale, T. F., Juluri, R., Sherer, E. A., Glowinski, E. A., Johnson, C. S., & Morelli, M. S. (2014). A risk index for advanced neoplasia on the second surveillance colonoscopy in patients with previous adenomatous polyps. Gastrointestinal endoscopy, 80(3), 471–478. https://doi.org/10.1016/j.gie.2014.03.042
Sherer, E. A., Fisher, D. A., Barnd, J., Jackson, G. L., Provenzale, D., & Haggstrom, D. A. (2016). The accuracy and completeness for receipt of colorectal cancer care using Veterans Health Administration administrative data. BMC health services research, 16, 50. https://doi.org/10.1186/s12913-016-1294-9
Aregbe, A. O., Sherer, E. A., Egorin, M. J., Scher, H. I., Solit, D. B., Ramanathan, R. K., Ramalingam, S., Belani, C. P., Ivy, P. S., & Bies, R. R. (2012). Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors. Cancer chemotherapy and pharmacology, 70(1), 201–205. https://doi.org/10.1007/s00280-012-1859-1
Sherer, E. A., Imler, T. D., & Imperiale, T. F. (2012). The effect of colonoscopy preparation quality on adenoma detection rates. Gastrointestinal endoscopy, 75(3), 545–553. https://doi.org/10.1016/j.gie.2011.09.022
Sehdev, A., Sherer, E. A., Hui, S. L., Wu, J., & Haggstrom, D. A. (2017). Patterns of computed tomography surveillance in survivors of colorectal cancer at Veterans Health Administration facilities. Cancer, 123(12), 2338–2351. https://doi.org/10.1002/cncr.30569
Li, C. H., Sherer, E. A., Lewis, L. D., & Bies, R. R. (2015). Clinical trial simulation to evaluate population pharmacokinetics and food effect: capturing abiraterone and nilotinib exposures. Journal of clinical pharmacology, 55(5), 556–562. https://doi.org/10.1002/jcph.449
Sherer, E. A., Bies, R. R., Clancy, P., Norman, P. E., & Golledge, J. (2012). Growth of screen-detected abdominal aortic aneurysms in men: a bayesian analysis. CPT: pharmacometrics & systems pharmacology, 1(10), e12. https://doi.org/10.1038/psp.2012.13
Sherer, E., Tocce, E., Hannemann, R. E., Rundell, A. E., & Ramkrishna, D. (2008). Identification of age-structured models: cell cycle phase transitions. Biotechnology and bioengineering, 99(4), 960–974. https://doi.org/10.1002/bit.21633
Tyler Shugg, PharmD, PhD
Elizabeth Sierra Potchanant, PhD
Broxmeyer, H. E., Capitano, M. L., Cooper, S., Potchanant, E. S., & Clapp, D. W. (2021). Numbers of long-term hematopoietic stem cells from bone marrow of fanca and fancc knockout mice can be greatly enhanced by their collection and processing in physioxia conditions. Blood cells, molecules & diseases, 86, 102492. https://doi.org/10.1016/j.bcmd.2020.102492
Abdul-Sater, Z., Cerabona, D., Potchanant, E. S., Sun, Z., Enzor, R., He, Y., Robertson, K., Goebel, W. S., & Nalepa, G. (2015). FANCA safeguards interphase and mitosis during hematopoiesis in vivo. Experimental hematology, 43(12), 1031–1046.e12. https://doi.org/10.1016/j.exphem.2015.08.013
Larissa Silva, PharmD
Rebecca Silvola, PharmD*
Shayne Small, MD
TBA.
Gerald So, PharmD*
No current publications.
Ashley Springer, PharmD, MSPGx, BS
No current publications.
Jasper Stevens, PhD
Stevens, J., Bies, R. R., Shekhar, A., & Anand, A. (2013). Bayesian model of Hamilton Depression Rating Score (HDRS) with memantine augmentation in bipolar depression. British journal of clinical pharmacology, 75(3), 791–798. https://doi.org/10.1111/j.1365-2125.2012.04398.x
Matthew Strother, MD*
Toru Takahaski, MD, PhD
None.
Irin Tanaudommongkon, PharmD*
None.
Alicia Teagarden, DO
Rhodes, S. D., Teagarden, A. M., Graner, B., Lutfi, R., & John, C. C. (2020). Brain Death Secondary to Rocky Mountain Spotted Fever Encephalitis. Case reports in critical care, 2020, 5329420. https://doi.org/10.1155/2020/5329420
Malin, S. W., Lutfi, R., Friedman, M. L., & Teagarden, A. M. (2018). Food Protein-Induced Enterocolitis Syndrome Causing Hypovolemic Shock and Methemoglobinemia. Case reports in critical care, 2018, 1903787. https://doi.org/10.1155/2018/1903787
Teagarden, A. M., & Mastropietro, C. W. (2017). Clinical significance of serum cortisol levels following surgery for congenital heart disease. Cardiology in the young, 27(2), 318–324. https://doi.org/10.1017/S104795111600055X
Teagarden, A. M., Leland, B. D., Rowan, C. M., & Lutfi, R. (2017). Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient. Case reports in critical care, 2017, 5121032. https://doi.org/10.1155/2017/5121032
Teagarden, A. M., Skiles, J. L., Beardsley, A. L., Hobson, M. J., Moser, E. A. S., Renbarger, J. L., & Rowan, C. M. (2017). Low serum albumin levels prior to pediatric allogeneic HCT are associated with increased need for critical care interventions and increased 6-month mortality. Pediatric transplantation, 21(6), 10.1111/petr.13016. https://doi.org/10.1111/petr.13016
Rowan, C. M., Teagarden, A. M., Cater, D. T., Moser, E. A. S., Baykoyannis, G., & Paczesny, S. (2020). Early high plasma ST2, the decoy IL-33 receptor, in children undergoing hematopoietic cell transplantation is associated with the development of post-transplant diabetes mellitus. Haematologica, 105(5), e249–e252. https://doi.org/10.3324/haematol.2019.222992
Beardsley, A. L., Teagarden, A. M., Abu-Sultaneh, S., & Lutfi, R. (2015). Devastating Ischemic Stroke Following Selective Arterial Embolization of a Large Chest Wall Aneurysmal Bone Cyst. Journal of pediatric hematology/oncology, 37(5), 406–408. https://doi.org/10.1097/MPH.0000000000000259
David Thacker, PharmD*
Michelle Torres, MD*
None.
Nieves Velez de Mendizabal, PhD
Velez de Mendizabal, N., Jackson, K., Eastwood, B., Swanson, S., Bender, D. M., Lowe, S., & Bies, R. R. (2015). A population PK model for citalopram and its major metabolite, N-desmethyl citalopram, in rats. Journal of pharmacokinetics and pharmacodynamics, 42(6), 721–733. https://doi.org/10.1007/s10928-015-9448-7
Vélez de Mendizábal, N., Jones, D. R., Jahn, A., Bies, R. R., & Brown, J. W. (2015). Nicotine and cotinine exposure from electronic cigarettes: a population approach. Clinical pharmacokinetics, 54(6), 615–626. https://doi.org/10.1007/s40262-014-0221-7
Harding, J. J., Moreno, V., Bang, Y. J., Hong, M. H., Patnaik, A., Trigo, J., Szpurka, A. M., Yamamoto, N., Doi, T., Fu, S., Calderon, B., Velez de Mendizabal, N., Calvo, E., Yu, D., Gandhi, L., Liu, Z. T., Galvao, V. R., Leow, C. C., & de Miguel, M. J. (2021). Blocking TIM-3 in Treatment-refractory Advanced Solid Tumors: A Phase Ia/b Study of LY3321367 with or without an Anti-PD-L1 Antibody. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(8), 2168–2178. https://doi.org/10.1158/1078-0432.CCR-20-4405
Velez de Mendizabal, N., Jimenez-Mendez, R., Cooke, E., Montgomery, C. J., Dawes, J., Rieder, M. J., Aleksa, K., Koren, G., Jacobo-Cabral, C. O., Gonzalez-Ramirez, R., Castañeda-Hernandez, G., & Carleton, B. C. (2015). A Compartmental Analysis for Morphine and Its Metabolites in Young Children After a Single Oral Dose. Clinical pharmacokinetics, 54(10), 1083–1090. https://doi.org/10.1007/s40262-015-0256-4
Goñi, J., van den Heuvel, M. P., Avena-Koenigsberger, A., Velez de Mendizabal, N., Betzel, R. F., Griffa, A., Hagmann, P., Corominas-Murtra, B., Thiran, J. P., & Sporns, O. (2014). Resting-brain functional connectivity predicted by analytic measures of network communication. Proceedings of the National Academy of Sciences of the United States of America, 111(2), 833–838. https://doi.org/10.1073/pnas.1315529111
Empey, P. E., Velez de Mendizabal, N., Bell, M. J., Bies, R. R., Anderson, K. B., Kochanek, P. M., Adelson, P. D., Poloyac, S. M., & Pediatric TBI Consortium: Hypothermia Investigators (2013). Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury. Critical care medicine, 41(10), 2379–2387. https://doi.org/10.1097/CCM.0b013e318292316c
Akil, A., Zhang, Q., Mumaw, C. L., Raiker, N., Yu, J., Velez de Mendizabal, N., Haneline, L. S., Robertson, K. A., Skiles, J., Diaz-Ricart, M., Carreras, E., Renbarger, J., Hanash, S., Bies, R. R., & Paczesny, S. (2015). Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(10), 1739–1745. https://doi.org/10.1016/j.bbmt.2015.07.004
Goñi, J., Avena-Koenigsberger, A., Velez de Mendizabal, N., van den Heuvel, M. P., Betzel, R. F., & Sporns, O. (2013). Exploring the morphospace of communication efficiency in complex networks. PloS one, 8(3), e58070. https://doi.org/10.1371/journal.pone.0058070
Li, C. H., Stratford, R. E., Jr, Velez de Mendizabal, N., Cremers, T. I., Pollock, B. G., Mulsant, B. H., Remington, G., & Bies, R. R. (2014). Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics. Journal of translational medicine, 12, 203. https://doi.org/10.1186/1479-5876-12-203
Velez de Mendizabal, N., Hutmacher, M. M., Troconiz, I. F., Goñi, J., Villoslada, P., Bagnato, F., & Bies, R. R. (2013). Predicting relapsing-remitting dynamics in multiple sclerosis using discrete distribution models: a population approach. PloS one, 8(9), e73361. https://doi.org/10.1371/journal.pone.0073361
Vélez de Mendizábal, N., Strother, R. M., Farag, S. S., Broxmeyer, H. E., Messina-Graham, S., Chitnis, S. D., & Bies, R. R. (2014). Modelling the sitagliptin effect on dipeptidyl peptidase-4 activity in adults with haematological malignancies after umbilical cord blood haematopoietic cell transplantation. Clinical pharmacokinetics, 53(3), 247–259. https://doi.org/10.1007/s40262-013-0109-y
Gulati, A., Bagnato, F., Villoslada, P., & Velez de Mendizabal, N. (2015). A Population Approach to Characterize Interferon Beta-1b Effect on Contrast Enhancing Lesions in Patients With Relapsing Remitting Multiple Sclerosis. CPT: pharmacometrics & systems pharmacology, 4(5), 295–304. https://doi.org/10.1002/psp4.36
Yana Voronstova, PharmD*
Raj Vuppalanchi, MD
TBA.
Alette Wessels, PhD
Syed Zaidi, PharmD, PhD
No current publications.
Jacob Zucker, MD
Carter, J., Cheng, L., Zucker, J., Marshall, M., Pollok, K., Murray, M., Li, L., & Renbarger, J. (2017). Use of Precision Medicine Molecular Profiling of Baseline Tumor Specimen May Not Benefit Outcomes in Children With Relapsed or Refractory Pediatric Sarcomas. Clinical pharmacology and therapeutics, 101(3), 328–330. https://doi.org/10.1002/cpt.599
Zucker, J., Temm, C., Czader, M., & Nalepa, G. (2016). A Child With Dyserythropoietic Anemia and Megakaryocyte Dysplasia Due to a Novel 5'UTR GATA1s Splice Mutation. Pediatric blood & cancer, 63(5), 917–921. https://doi.org/10.1002/pbc.25871