Mark H. Kaplan

Mark H. Kaplan, PhD

Billie Lou Wood Professor of Pediatrics

Bio

Professor Kaplan received an Honours B.Sc. from the University of Windsor in 1987 (Biology) and a PhD. from Wayne State University in 1992 (Immunology and Microbiology). He did postdoctoral work at the University of Texas Southwestern Medical Center and at the Harvard University School of Public Health. He joined the Faculty in the Indiana University School of Medicine in 1998 as an Assistant Professor of Microbiology and Immunology. In 2005, he moved to the Department of Pediatrics to become the Director of Pediatric Pulmonary Basic Research. In 2008, he was promoted to Professor and in 2014 was honored with the Billie Lou Wood Professorship. In 2017, Dr. Kaplan was named as Associate Director of the HB Wells Center for Pediatric Research.

Professor Kaplan’s work is focused on understanding the function of transcription factors in the development of T helper cell subsets. He has a long standing interest in Signal Transducer and Activator of Transcription or STAT proteins that are activated downstream of cytokines. His more recent work has made great progress towards understanding the development and function of IL-9-secreting T cells in the development of allergic inflammation. His interests lie in understanding how T cell subsets contribute to allergic and autoimmune inflammation.

Professor Kaplan has been on the Editorial Boards of the Journal of Immunology and JAK-STAT and is currently  Senior Editor for the new American Association of Immunologists journal ImmunoHorizons. He has served on and chaired numerous study sections for grant application to the National Institutes of Health, and other private and international review panels. He has served on the IUSM Biomedical Research Committee for over ten years and is currently the co-chair. He is also the Director of the NIH-funded T32 Training Program in Immunology and Infectious Diseases.

 

Key Publications

Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, Han L, Nguyen ET, McKinley CD, Tepper RS, Robertson MJ, Perumal NB, Nutt SL and Kaplan MH. (2010) The transcription factor PU.1 is required for the development of IL-9-secreting T cells and allergic inflammation. Nature Immunology. 11:527-534. PMC3136246.

Jabeen R, Goswami R, Awe O, Kulkarni A, Nguyen ET, Attenasio A, Walsh D, Olson MR, Kim MH, Tepper RS, Sun J, Kim CH, Taparowsky EJ, Zhou B and Kaplan MH. (2013). Th9 cell development requires a BATF-regulated transcriptional network. Journal of Clinical Investigation. 123(11):4641–4653. PMC3809790.

Sehra S, Yao W, Nguyen ET, Glosson-Byers NL, Akhtar N, Zhou B, and Kaplan MH. (2015). Th9 cells are required for tissue mast cell accumulation during allergic inflammation. J Allergy Clin Immunol. 136(2):433-440.e1. PMC4530056

Kaplan MH, Hufford MM, Olson, MR. (2015) The Development and in vivo Function of TH9 cells. Nature Reviews Immunol.15:295-307. PMC4445728.    

Serezani APM, Bozdogan G, Sehra S, Walsh D, Krishnamurthy P, Potchanant EAS, Nalepa G, Goenka S, Turner MJ, Spandau DF, Kaplan MH. (2017) IL-4 impairs wound healing potential in the skin by repressing fibronectin expression. J. Allergy Clin Immunol. 139(1):142-151.e5. PMC5222746    

Olson MR, Ulrich BJ, Hummel SA, Khan I, Meuris B, Cherukuri Y, Dent AL, Janga SC, and Kaplan MH. (2017) Paracrine IL-2 is required for optimal type 2 effector cytokine production. J. Immunol. 198:4352-4359. PMCID:PMC5470780

Ulrich BJ, Verdan FF, McKenzie ANJ, Kaplan MH, and Olson MR. (2017) STAT3 activation impairs the stability of Th9 cells. J. Immunol. 198(6):2302-2309. PMC5340611    

Connect


(317) 278-3696 


Ped-Pulmonology
Wells Center for Pediatric Research 1044 West Walnut St. Room 202
Indianapolis, IN 46202


  

Pediatrics

Titles & Appointments

  • Professor of Microbiology & Immunology
  • Adjunct Professor of Biochemistry & Molecular Biology