Stanley M. Spinola

Stanley M. Spinola, MD

Professor of Microbiology & Immunology



Dr. Spinola received a B.A. from Brown University in 1974 (Biology) and a M.D. from Georgetown University in 1978.  He completed a residency in Internal Medicine and Pediatrics at the University of North Carolina at Chapel Hill in 1982 and served in the National Health Service Corps from 1982-1984.  He completed a fellowship in Adult and Pediatric Infectious Diseases at the University of North Carolina in 1987, where he was funded by the NRSA mechanism.  From 1987 to 1993, Dr. Spinola was at the State University of New York at Buffalo as an Assistant and then Associate Professor in the Department of Medicine. He came to Indiana University in 1993 to join the Division of Infectious Diseases in the Department of Medicine and was named the Division Director in 1995.  In 1999, Dr. Spinola was named the first David H. Jacobs Professor of Infectious Diseases; he became Chair of the Department of Microbiology and Immunology in October 2010 and is currently a Professor of Medicine, Microbiology and Immunology and Pathology and Laboratory Medicine. He has been NIH funded from 1990 through 2021. He is a member of the American Society for Clinical Investigation and a Fellow in the American Academy of Microbiology and in the Infectious Diseases Society of America.  He served for 2 terms as a Member and Chair of the Microbiology and Infectious Diseases Review Committee, a standing study section of NIAID, and played a major role in organizing the Biennial International Symposia on Haemophilus ducreyi Pathogenesis for over  20 years.  He has served as primary mentor for 7 graduate students, 7 ID fellows, 6 PhD postdoctoral fellows, 20 short term trainees, and 5 faculty members for Developmental Awards, K08 or K22 awards. He was the recipient of the  Indiana University School of Medicine 2017 Basic Science Excellence in Faculty Mentoring Award.



Key Publications

Recent publications (since 2015)

  1. Trombley MP, Post DM, Rinker SD, Reinders LM, Fortney KR, Zwickl BW, Janowicz DM, Baye FM, Katz BP, Spinola SM, Bauer ME.  Phosphoethanolamine transferase LptA in Haemophilus ducreyi modifies Lipid A and contributes to human defensin resistance in vitro. PLoS One 2015; Apr 22;10(4):e0124373.m PMCID: PMC4406763
  2. van Rensburg JJ, Fortney KR, Chen L, Kreiger A, Lima BP, Wolfe AJ, Katz BP, Zhang Z-Y, Spinola SM. Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system. Antimicrob Agents Chemother. 2015; 59: 3789-3799. PMCID: PMC25870061
  3. Gangaiah D, Webb KM, Humphreys TL, Fortney KR, Toh E, Tai A, Katz SS, Pillay A, Chen C-Y, Roberts SA, Munson, RS, Jr., Spinola SM. Haemophilus ducreyi cutaneous ulcer strains are nearly identical to Class I genital ulcer strains. PLoS Neglected Tropical Diseases 2015; July 6; 9(7): e0003918. PMCID: PMC4492979
  4. Holley C, Zhang X, Fortney KR, Ellinger S, Johnson P, Baker B, Liu Y, Janowicz DM, Katz BP, Munson, RS, Jr., Spinola SM. DksA and (p)ppGpp have unique and overlapping contributions to Haemophilus ducreyi pathogenesis in humans. Infect. Immun. 2015; 83: 3281-3292. PMCID: PMC4496623
  5.    *van Rensburg JJ, Lin H, Gao X, Toh E, Fortney KR, Ellinger S, Zwickl B, Janowicz DM, Katz BP, Nelson DE, Dong Q, Spinola SM. The human skin microbiome associates with the outcome of and is influenced by bacterial infection. mBio. 2015;6(5). doi: 10.1128/mBio.01315-15. PMCID: PMC4600114 * Featured in The Scientist, 9/6/15, mBiosphere 9/15/15, and Microbe 2015. 10: 411
  6. Gangaiah D, Marinov GK, Roberts SA, Robson J, Spinola SM. Draft whole-genome sequence of the Haemophilus ducreyi strain AUSPNG1 isolated from a cutaneous ulcer of a child from Papua New Guinea. Genome Announc. 2016 Feb 4;4(1). pii: e01661-15. doi: 10.1128/genomeA.01661-15. PMCID: PMC4742684
  7. Gangaiah D, Zhang X, Baker B, Fortney KR, Holley C, Munson, RS, Jr., Liu Y, Spinola SM. Haemophilus ducreyi seeks alternative carbon sources and adapts to nutrient stress and anaerobiosis during experimental infection of human volunteers. Infect. Immun. 2016; 84: 1514-1525. PMCID: PMC4862733
  8. Singer M, Li W, Morré SA, Ouburg S, Spinola, SM. Host polymorphisms in TLR9 and IL10 are associated with the outcomes of experimental Haemophilus ducreyi infection in human volunteers.  J. Infect. Dis. 2016; 214: 489-95. PMCID: PMC4936646
  9. Gangaiah D, Spinola SM. Haemophilus ducreyi cutaneous ulcer strains diverged from both class I and class II genital ulcer strains: implications for epidemiological studies. PLoS Negl. Trop. Dis. 2016 Dec 27;10(12):e0005259. doi: 10.1371/journal.pntd.0005259.  PMCID: PMC5222509
  10. Houinei W, Godornes C, Kapa A, Mooring EQ, González-Beiras C, Knauf S, Watup R, Paru R, Advent P, Bieb S, Sanz S, Spinola SM, Lukehart SA, Mitjà O. Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea. PLoS Negl Trop Dis. 2017 May 10;11(5):e0004958. doi: 10.1371/journal.pntd.0004958. PMCID: PMC5425006
  11.  Gangaiah D, Raterman EL, Wu H, Fortney KR, Gao H, Liu Y, Jerse AE, Spinola SM. Both MisR (CpxR) and MisS (CpxA) Are Required for Neisseria gonorrhoeae Infection in a Murine Model of Lower Genital Tract Infection. Infection and immunity. 2017;85(9). doi: 10.1128/IAI.00307-17. PubMed PMID: 28652307.
  12. Dbeibo L, van Rensburg J, Smith S, Fortney KR, Gangaiah D, Gao H, Marzoa J, Liu Y, Mobley H, Spinola SM. Evaluation of CpxRA as a therapeutic target for uropathogenic Escherichia coli  Infection and Immunity. 2018; 86(3). pii: e00798-17. PMCID: PMC5820967
  13. Grant JC, * González-Beiras C, Amick KM, Fortney KR, Gangaiah D, Humphreys TL, Mitjà O, Abecasis A, Spinola SM. Multiple class I and class II Haemophilus ducreyi strains cause cutaneous ulcers in children on an endemic island. Clin. Infect. Dis. 2018 67:1768-1774. doi: 10.1093/cid/ciy343. PMCID:PMC6233678


(317) 274-0506 

Microbiology & Immunology
MS 420 635 Barnhill Dr.
Indianapolis , IN 46202-5120


Global Health
Infectious Diseases

Titles & Appointments

  • Professor of Medicine
  • Professor of Pathology & Laboratory Medicine
  • Chair, Department of Microbiology and Immunology
  • Professor of Medicine, Microbiology, Immunology, Pathology and Laboratory Medicine
  • Former Director Division of Infectious Diseases 1995-2010
  • Former David H. Jacobs Professor of Medicine