Jamie L. Renbarger

Jamie L. Renbarger, MD, MS

Caroline Symmes Professor of Pediatric Cancer Research



My career path has been driven by my passion for taking care of patients, developing relationships, and teaching. During my initial pediatric rotation as a third year medical student, I found that I loved caring for children because of their resiliency and innocence. I was also attracted to pediatrics because of the multitude of academic opportunities in the field. Early in my residency, I developed a passion for pediatric hematology/oncology as well as pediatric critical care, attracted by the medical and psychosocial intensities of both fields. Within pediatric hematology/oncology, I was particularly drawn to the clinical care of pediatric hematopoietic stem cell transplant patients and ultimately chose this over critical care due to the opportunity to develop long-term relationships with patients and their families who we have the privilege to see for many years. I embarked upon my pediatric hematology/oncology fellowship training at Baylor College of Medicine with an open mind and an interest in getting good research experience as a foundation for my future academic career. I have always enjoyed thinking about medications, their mechanisms of action, and variability in both response and side effects. As such I decided to join the cancer pharmacology group for my fellowship research. I became passionate about developing ways to predict response to specific therapies we use in children with cancer and, in particular, understanding inter-individual variability in responses and toxicities. My hope is that my passion and research will lead to a better understanding on how to best treat individual children with cancer where the ultimate, initial goal is disease cure rather than control of symptoms. I feel privileged to come to work and think about ways to improve our approaches to caring for our patients.


Key Publications


Smith, E. M. L., Li, L., Chiang, C., Thomas, K., Hutchinson, R., Wells, E. M.,  Ho, R. H., Skiles, J., Chakraborty, A., & Renbarger, J.  Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphocytic leukemia.  J Peripher Nerv Syst. 2015 Mar;20(1):37-46. doi: 10.1111/jns.12114.




Jayachandran D, Ramkrishna U, Skiles J, Renbarger J, Ramkrishna D. Revitalizing personalized medicine: respecting biomolecular complexities beyond gene expression. CPT Pharmacometrics Syst Pharmacol. 2014 Apr 16;3:e110.




Topletz AR, Dennison JB, Barbuch RJ, Hadden CE, Hall SD, Renbarger JL.  The Relative Contributions of CYP3A4 and CYP3A5 to the Metabolism of Vinorelbine. Drug Metab Dispos. 2013 Sep;41(9):1651-61.




Smith EM, Li L, Hutchinson RJ, Ho R, Burnette WB, Wells E, Bridges C, Renbarger J.  Measuring Vincristine-Induced Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia.  Cancer Nurs. 2013 Sep-Oct;36(5):E49-60. [Epub ahead of print]




Nalepa G, Barnholtz-Sloan J, Enzor R, Dey D, He Y, Gehlhausen JR, Lehmann AS, Park SJ, Yang Y, Yang X, Chen S, Guan X, Chen Y, Renbarger J, Yang FC, Parada LF, Clapp W. The tumor suppressor CDKN3 controls mitosis. J Cell Biol. 2013 Jun 24;201(7):997-1012. doi: 10.1083/jcb.201205125. Epub 2013 Jun 17. 




Haas DM, Quinney SK, Clay JM, Renbarger JL, Hebert MF, Clark S, Umans JG, Caritis SN; for the Obstetric-Fetal Pharmacology Research Units Network.  Nifedipine Pharmacokinetics Are Influenced by CYP3A5 Genotype When Used as a Preterm Labor Tocolytic.  Am J Perinatol. 2012 Aug 8. [Epub ahead of print]. 




Yancey A, Harris MS, Egbelakin A, Gilbert J, Pisoni DB, Renbarger J. Risk factors for cisplatin-associated ototoxicity in pediatric oncology patients. Pediatr Blood Cancer. 2012 Jul 15; 59(1):144-8.




Haas DM, Quinney SK, McCormick CL, Jones DR, Renbarger JL.  A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic.  J Matern Fetal Neonatal Med. 2011 Jun 7. Epub ahead of print.




Langholz B, Skolnik J, Barrett J, Renbarger J, Seibel N, Zajicek A, Arndt C. Dactinomycin and vincristine toxicity in the treatment of childhood cancer: A retrospective study from the Children’s Oncology Group.  Pediatr Blood Cancer. 2011 Aug;57(2):252-7. 2010 Dec 1. Epub ahead of print.




Lehmann AS, Haas DM, McCormick CL, Skaar TC, Renbarger JL. Collection of human genomic DNA from neonates: a comparison between umbilical cord blood and buccal swabs.  Am J Obstet Gynecol. 2011 Apr;204(4):362.e1-6. Epub 2011 Feb 16.




(317) 944-8784 

705 Riley Hospital Drive ROC 4340
Indianapolis, IN 46202


Titles & Appointments

  • Professor of Pediatrics
  • Professor of Medicine
  • Professor of Obstetrics & Gynecology
  • Division Chief, Pediatric Hematology/Oncology