5404-Marshall, Mark

Mark S. Marshall, PhD

Senior Research Professor of Pediatrics

Phone 317-278-3159
705 Riley Hospital Drive
RI 2606

Indianapolis, IN 46202


Dedicated Cancer Research Professor with more than 28 years of experience in academia and the biotechnology industry. Driven professional recognized as a leader in the fields of Ras oncogene function, cell cycle and cancer genetics. Scientific leader with a proven career history of spearheading successful oncology drug programs while managing cross-disciplined research teams to deliver three clinical molecules. Visionary professional with a current focus on delivering precision medicine options to clinical pediatric oncologists. Driven leader directing high-profile academic collaborations, co-inventing 9 patents, and authoring more than 90 scientific papers, FDA study reports, and book chapters.

Key Publications

Barnard, D., Diaz, H., Burke, T., Donoho, G., Beckmann, R., Jones, B., Barda, D., King, C. and M. Marshall. 2016. LY2603618, a Selective CHK1 Inhibitor, Enhances the Anti-tumor Effect of Gemcitabine in Xenograft Tumor Models. Invest New Drugs. 34 (1):49-60.

King, C., Diaz, H., McNeely, S., Barnard, D., Dempsey, J., Blosser, W., Beckmann, R., Barda, D. and Marshall, M. 2015. LY2606368 causes replication catastrophe and anti-tumor effects through CHK1-dependent mechanisms. Mol Cancer Ther. 14 (9):2004-13.

King, C., Diaz, H., Barnard, D., Barda, D., Clawson, D., Blosser, W., Cox, K., Guo, S. and Marshall, M. 2013. Characterization and preclinical development of LY2603618: A selective and potent Chk1 inhibitor. Invest New Drugs. 32(2):213-26.

Titles & Appointments

  • Senior Research Professor of Pediatrics
  • Adjunct Professor of Medicine
  • Adjunct Professor of Biochemistry & Molecular Biology
  • Professor of Medicine, Biochemistry and Molecular Biology
  • Education
    1986 PhD Princeton University
    1981 MS Brigham Young University
    1980 BS Brigham Young University
  • Research

    Precision medicine; signal transduction pathways in human tumors; Ras family GTPases;Raf protein kinase; Protein structure/function.

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