Carmella Evans-Molina

Carmella Evans-Molina, MD, PhD

J. O. Ritchey Scholar in Medicine


Dr. Evans-Molina’s research program is focused on defining the molecular and inflammatory etiologies of β-cell dysfunction that contribute to the pathophysiology of diabetes mellitus.  Her lab has several ongoing laboratory-based projects focused on:

1.       Understanding the pathways that regulate intracellular calcium homeostasis in the pancreatic β-cell endoplasmic reticulum, Golgi apparatus, and secretory granules;

2.       Defining the role of intracellular calcium dyshomeostasis during the evolution of Type 1 and Type 2 diabetes; 

3.       The development and implementation of novel imaging techniques to monitor β-cell calcium flux under conditions of health and disease; and

4.       Elucidating pathways that lead to macrophage activation and islet infiltration in Type 1 and Type 2 diabetes.

 In addition, Dr. Evans-Molina’s lab has ongoing translational and clinical projects focused on the discovery and validation of novel serum biomarkers that identify early β cell-stress in clinically silent Type 1 diabetes, with the goal of applying these biomarkers in diabetes prevention paradigms or as surrogate clinical endpoints in response to therapeutic interventions. She is an investigator in the Type 1 Diabetes TrialNet Clinical Network, where she serves as as a Scientific Advisor, Chair of the β-Cell and Metabolism Working Group, and.Chair of the Long-Term Investigative Follow-Up (LIFT) study.  Dr. Evans-Molina is also a member of the NIH Human Islet Research Network, where she serves as Chair of the Translational Working Group.  Her research is supported by grants from the NIH, JDRF, and the VA. 

Dr. Evans-Molina earned her M.D. degree from Marshall University in Huntington, WV and completed her residency training in Internal Medicine at the Massachusetts General Hospital in Boston, MA.  She completed her subspecialty training in Endocrinology and Metabolism at the University of Virginia in Charlottesville, VA.  In parallel with this phase of her clinical training, Dr. Evans-Molina earned a Ph.D. in Pharmacology, also from the University of Virginia.  She joined the faculty of the Indiana University School of Medicine in 2008. Dr. Evans-Molina is the J.O. Ritchey Scholar in Medicine and has been named an IU School of Medicine Showalter Scholar.  She is an Associate Professor in the Department of Medicine and holds joint appointments in the Departments of Cellular and Integrative Physiology, Biochemistry and Molecular Biology and the Herman B. Wells Center for Pediatric Research. She currently serves as an Associate Director of Development and Community Engagement for the Indiana University Center for Diabetes and Metabolic Diseases (CDMD) and Director of CDMD Islet and Physiology Core.  Dr. Evans-Molina is an editorial board member for the journals Translational Research and Endocrinology . 





(317) 278-3177 

VanNuys Med Sci Bldg, Suite 2031 A 635 Barnhill Dr
Indianapolis, IN 46202-5120


Titles & Appointments

  • Associate Professor of Medicine
  • Adjunct Associate Professor of Cellular & Integrative Physiology
  • Adjunct Associate Professor of Biochemistry & Molecular Biology
  • Director of Diabetes Research in the Herman B Wells Center for Pediatric Research