Ann E. Kosobud, PhD
Associate Scientist in Neurology
My graduate training was in the lab of Dr. John C. Crabbe, where I assisted in developing the genetically selected alcohol withdrawal seizure prone and resistant mouse lines. My postdoctoral work was in the lab of Dr. John K. Chapin at Hahnemann University in Philadephia, using multi-single neuron electrophysiology to study motivated behavior in awake, behaving rats. I continued similar work with Dr. George V. Rebec at Indiana University, Bloomington, where I also began a collaboration withDr. William Timberlake studying circadian entrainment by drugs of abuse. I am currently working with Drs. Sean J. O’Connor and Martin P. Plawecki, studying responses to alcohol in humans, using i.v. administration to achieve precisely control of breath alcohol concentrations.
GH 4600 NEUR
The primary aim of my research has been to understand the neural mechanisms underlying addictive behavior (drug seeking and taking), to aid development of treatments. I have pursued this interest using a variety of research approaches, including genetic selection studies in mice, single neuron recording in awake, behaving rats, studies of the circadian entrainment properties of drugs of abuse, and most recently, laboratory studies of human alcohol intake using iv infusion of alcohol solutions.