Sharon M. Moe, MD

My research investigates the relationship of kidney disease, vascular calcification, bone, and disorders of mineral metabolism known as CKD-Mineral Bone Disorder (CKD-MBD). Our research is funded by the NIH, Veterans Administration, Food and Drug Administration, and industry and utilizes in vivo, ex vivo and in vitro techniques to investigate the pathophysiology of arterial medial calcification and bone disease.   We are using a naturally occurring rat model of CKD that spontaneously develops all manifestations of CKD-MBD to study 1) mechanisms by which matrix vesicles propagate arterial calcification, 2) how oxidative stress alters vasculature, 3) the role of advanced glycation end product cross linking of bone collagen predisposes to fracture, 4) mechanisms of sudden cardiac death, 5) how impaired muscle function occurs with progressive CKD, and 6) micro RNA as biomarkers.    We also have active investigator initiated clinical trials studying the natural progression of frailty and muscle weakness in patients as they start on dialysis, novel phosphate binders and the effect on phosphate balance, how nutrition can be enhanced in patients on dialysis, and the use of pioglitazone as a treatment for ADPKD.  

Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways.

Chen NX; O'Neill KD; Moe SM; Kidney international, 2017 Oct 9

Calcium-Sensing Receptor Genotype and Response to Cinacalcet in Patients Undergoing Hemodialysis.

Moe SM; Wetherill L; Decker BS; Lai D; Abdalla S; Long J; Vatta M; Foroud TM; Chertow GM; Clinical journal of the American Society of Nephrology : CJASN, 2017 Jun 19

Renal Osteodystrophy or Kidney-Induced Osteoporosis?

Moe SM; Current osteoporosis reports, 2017 Jun

Moving Beyond the Assumed: Improving Fistula Success Rates.

Wish JB; Moe SM; Journal of the American Society of Nephrology : JASN, 2017 Jul 21

Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters.

Ketteler M; Block GA; Evenepoel P; Fukagawa M; Herzog CA; McCann L; Moe SM; Shroff R; Tonelli MA; Toussaint ND; Vervloet MG; Leonard MB; Kidney international, 2017 Jul

Effect of Etelcalcetide vs Placebo on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: Two Randomized Clinical Trials.

Block GA; Bushinsky DA; Cunningham J; Drueke TB; Ketteler M; Kewalramani R; Martin KJ; Mix TC; Moe SM; Patel UD; Silver J; Spiegel DM; Sterling L; Walsh L; Chertow GM; JAMA, 2017 Jan 10

Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial.

Block GA; Bushinsky DA; Cheng S; Cunningham J; Dehmel B; Drueke TB; Ketteler M; Kewalramani R; Martin KJ; Moe SM; Patel UD; Silver J; Sun Y; Wang H; Chertow GM; JAMA, 2017 Jan 10

Calcium Homeostasis in Health and in Kidney Disease.

Moe SM; Comprehensive Physiology, 2016 Sep 15

Fractures in Patients with CKD: Time for Action.

Moe SM; Nickolas TL; Clinical journal of the American Society of Nephrology : CJASN, 2016 Oct 24

Intracellular calcium increases in vascular smooth muscle cells with progression of chronic kidney disease in a rat model.

Rodenbeck SD; Zarse CA; McKenney-Drake ML; Bruning RS; Sturek M; Chen NX; Moe SM; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2016 Aug 9

Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease.

Avin KG; Chen NX; Organ JM; Zarse C; O'Neill K; Conway RG; Konrad RJ; Bacallao RL; Allen MR; Moe SM; PloS one, 2016 Aug 3

Calcium as a cardiovascular toxin in CKD-MBD.

Moe SM; Bone, 2016 Aug 27

Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease.

Organ JM; Srisuwananukorn A; Price P; Joll JE; Biro KC; Rupert JE; Chen NX; Avin KG; Moe SM; Allen MR; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2015 Oct 5

Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease.

Newman CL; Creecy A; Granke M; Nyman JS; Tian N; Hammond MA; Wallace JM; Brown DM; Chen N; Moe SM; Allen MR; Kidney international, 2015 Oct 21

Cinacalcet, dialysate calcium concentration, and cardiovascular events in the EVOLVE trial.

Pun PH; Abdalla S; Block GA; Chertow GM; Correa-Rotter R; Dehmel B; Drüeke TB; Floege J; Goodman WG; Herzog CA; London GM; Mahaffey KW; Moe SM; Parfrey PS; Wheeler DC; Middleton JP; Hemodialysis international. International Symposium on Home Hemodialysis, 2015 Nov 13

Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy.

Moe SM; Chen NX; Newman CL; Organ JM; Kneissel M; Kramer I; Gattone VH 2nd; Allen MR; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015 Mar

ASN Presidential Address 2014: Moving Past Nephrology's Midlife Crisis.

Moe SM; Journal of the American Society of Nephrology : JASN, 2015 Jan 29

The effect of a diet containing 70% protein from plants on mineral metabolism and musculoskeletal health in chronic kidney disease.

Moorthi RN; Armstrong CL; Janda K; Ponsler-Sipes K; Asplin JR; Moe SM; American journal of nephrology, 2015 Jan 20

Bone marrow fat is increased in chronic kidney disease by magnetic resonance spectroscopy.

Moorthi RN; Fadel W; Eckert GJ; Ponsler-Sipes K; Moe SM; Lin C; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015 Feb 21

The Effects of Cinacalcet in Older and Younger Patients on Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial.

Parfrey PS; Drüeke TB; Block GA; Correa-Rotter R; Floege J; Herzog CA; London GM; Mahaffey KW; Moe SM; Wheeler DC; Kubo Y; Dehmel B; Goodman WG; Chertow GM; for the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators; Clinical journal of the American Society of Nephrology : CJASN, 2015 Feb 20

Subcutaneous nerve activity and mechanisms of sudden death in a rat model of chronic kidney disease.

Zhao Y; Chen NX; Shirazi JT; Shen C; Lin SF; Fishbein MC; Moe SM; Chen PS; Heart rhythm : the official journal of the Heart Rhythm Society, 2015 Dec 29

Effects of cinacalcet on atherosclerotic and nonatherosclerotic cardiovascular events in patients receiving hemodialysis: the EValuation Of Cinacalcet HCl Therapy to Lower CardioVascular Events (EVOLVE) trial.

Wheeler DC; London GM; Parfrey PS; Block GA; Correa-Rotter R; Dehmel B; Drüeke TB; Floege J; Kubo Y; Mahaffey KW; Goodman WG; Moe SM; Trotman ML; Abdalla S; Chertow GM; Herzog CA; EValuation Of Cinacalcet HCl Therapy to Lower CardioVascular Events (EVOLVE) Trial Investigators; Journal of the American Heart Association, 2014 Nov 17

Pathogenesis of arrhythmias in a model of CKD.

Hsueh CH; Chen NX; Lin SF; Chen PS; Gattone VH 2nd; Allen MR; Fishbein MC; Moe SM; Journal of the American Society of Nephrology : JASN, 2014 May 22

Adipocyte induced arterial calcification is prevented with sodium thiosulfate.

Chen NX; O'Neill K; Akl NK; Moe SM; Biochemical and biophysical research communications, 2014 May 10

Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease.

Newman CL; Moe SM; Chen NX; Hammond MA; Wallace JM; Nyman JS; Allen MR; PloS one, 2014 Jun 9

Nicotinamide treatment in a murine model of familial tumoral calcinosis reduces serum Fgf23 and raises heart calcium.

Reilly AM; Gray AK; Moe SM; Ichikawa S; Bone, 2014 Jul 4

Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease.

Allen MR; Newman CL; Chen N; Granke M; Nyman JS; Moe SM; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2014 Dec 3

Effects of Cinacalcet on Fracture Events in Patients Receiving Hemodialysis: The EVOLVE Trial.

Moe SM; Abdalla S; Chertow GM; Parfrey PS; Block GA; Correa-Rotter R; Floege J; Herzog CA; London GM; Mahaffey KW; Wheeler DC; Dehmel B; Goodman WG; Drüeke TB; for the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators; Journal of the American Society of Nephrology : JASN, 2014 Dec 11

A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD.

Moe SM; Chen NX; Newman CL; Gattone VH 2nd; Organ JM; Chen X; Allen MR; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014 Apr

Adverse mandibular bone effects associated with kidney disease are only partially corrected with bisphosphonate and/or calcium treatment.

Allen MR; Chen NX; Gattone VH 2nd; Moe SM; American journal of nephrology, 2013 Nov 22

What have we learned about chronic kidney disease-mineral bone disorder from the EVOLVE and PRIMO trials?

Moe SM; Thadhani R; Current opinion in nephrology and hypertension, 2013 Nov

Decreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD).

Chen NX; Kiattisunthorn K; O'Neill KD; Chen X; Moorthi RN; Gattone VH 2nd; Allen MR; Moe SM; PloS one, 2013 May 22

Recent advances in the noninvasive diagnosis of renal osteodystrophy.

Moorthi RN; Moe SM; Kidney international, 2013 Jun 26

Transglutaminase 2 accelerates vascular calcification in chronic kidney disease.

Chen NX; O'Neill K; Chen X; Kiattisunthorn K; Gattone VH; Moe SM; American journal of nephrology, 2013 Feb 28

Hemodialysis does not alter in vitro hepatic CYP3A4 and CYP2D6 metabolic activity in uremic serum.

Decker BS; O'Neill KD; Chambers MA; Slaven JE; Yu Z; Jones DR; Moe SM; Clinical pharmacology : advances and applications, 2013 Dec 10

Worsening endothelial function with efavirenz compared to protease inhibitors: a 12-month prospective study.

Gupta SK; Shen C; Moe SM; Kamendulis LM; Goldman M; Dubé MP; PloS one, 2012 Sep 20

Vascular calcification: pathophysiology and risk factors.

Chen NX; Moe SM; Current hypertension reports, 2012 Jun

Gentamicin pharmacokinetics and pharmacodynamics during short-daily hemodialysis.

Decker BS; Mohamed AN; Chambers M; Kraus MA; Moe SM; Sowinski KM; American journal of nephrology, 2012 Jul 18

Oral calcium carbonate affects calcium but not phosphorus balance in stage 3-4 chronic kidney disease.

Hill KM; Martin BR; Wastney ME; McCabe GP; Moe SM; Weaver CM; Peacock M; Kidney international, 2012 Dec 19

Skeletal effects of zoledronic acid in an animal model of chronic kidney disease.

Allen MR; Chen NX; Gattone VH 2nd; Chen X; Carr AJ; LeBlanc P; Brown D; Moe SM; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012 Aug 21

CKD-mineral and bone disorder: core curriculum 2011.

Moorthi RN; Moe SM; American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011 Oct 21

The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.

Moe SM; Radcliffe JS; White KE; Gattone VH 2nd; Seifert MF; Chen X; Aldridge B; Chen NX; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011 Nov

Calcimimetics inhibit renal pathology in rodent nephronophthisis.

Chen NX; Moe SM; Eggleston-Gulyas T; Chen X; Hoffmeyer WD; Bacallao RL; Herbert BS; Gattone VH 2nd; Kidney international, 2011 Jun 1

Efficacy of sodium thiosulfate for the treatment for calciphylaxis.

Noureddine L; Landis M; Patel N; Moe SM; Clinical nephrology, 2011 Jun

Activation of arterial matrix metalloproteinases leads to vascular calcification in chronic kidney disease.

Chen NX; O'Neill KD; Chen X; Kiattisunthorn K; Gattone VH; Moe SM; American journal of nephrology, 2011 Jul 23

Optimal vitamin D, calcitriol, and vitamin D analog replacement in chronic kidney disease: to D or not to D: that is the question.

Moorthi RN; Kandula P; Moe SM; Current opinion in nephrology and hypertension, 2011 Jul

Confusion on the complexity of calcium balance.

Moe SM; Seminars in dialysis, 2010 Sep

Vancomycin pharmacokinetics and pharmacodynamics during short daily hemodialysis.

Decker BS; Kays MB; Chambers M; Kraus MA; Moe SM; Sowinski KM; Clinical journal of the American Society of Nephrology : CJASN, 2010 Jul 8

RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC).

Chen NX; Chen X; O'Neill KD; Atkinson SJ; Moe SM; American journal of physiology. Renal physiology, 2010 Jul 7

A randomized trial of cholecalciferol versus doxercalciferol for lowering parathyroid hormone in chronic kidney disease.

Moe SM; Saifullah A; LaClair RE; Usman SA; Yu Z; Clinical journal of the American Society of Nephrology : CJASN, 2010 Jan 7

Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease.

Moe SM; Zidehsarai MP; Chambers MA; Jackman LA; Radcliffe JS; Trevino LL; Donahue SE; Asplin JR; Clinical journal of the American Society of Nephrology : CJASN, 2010 Dec 23

Hepatitis C increases the risk of progression of chronic kidney disease in patients with glomerulonephritis.

Noureddine LA; Usman SA; Yu Z; Moorthi RN; Moe SM; American journal of nephrology, 2010 Aug 16

Calcimimetic inhibits late-stage cyst growth in ADPKD.

Gattone VH 2nd; Chen NX; Sinders RM; Seifert MF; Duan D; Martin D; Henley C; Moe SM; Journal of the American Society of Nephrology : JASN, 2009 May 7

R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).

Moe SM; Seifert MF; Chen NX; Sinders RM; Chen X; Duan D; Henley C; Martin D; Gattone VH 2nd; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009 Mar 3

Medication changes based on echocardiography in dialysis patients.

Chong CK; Muzoora M; Eckert GJ; Kamalesh M; Moe SM; Hemodialysis international. International Symposium on Home Hemodialysis, 2009 Jun 22

Review article: Chronic kidney disease-mineral bone disorder: have we got the assays right?

Zidehsarai MP; Moe SM; Nephrology (Carlton, Vic.), 2009 Jun

Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells.

Chen NX; Kircelli F; O'Neill KD; Chen X; Moe SM; Kidney international, 2009 Dec 16

A rat model of chronic kidney disease-mineral bone disorder.

Moe SM; Chen NX; Seifert MF; Sinders RM; Duan D; Chen X; Liang Y; Radcliff JS; White KE; Gattone VH 2nd; Kidney international, 2008 Sep 17

Annexin-mediated matrix vesicle calcification in vascular smooth muscle cells.

Chen NX; O'Neill KD; Chen X; Moe SM; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008 Nov

Improving global outcomes in mineral and bone disorders.

Moe SM; Drüeke T; Clinical journal of the American Society of Nephrology : CJASN, 2008 Nov

Precision of biomarkers to define chronic inflammation in CKD.

LaClair R; O'Neal K; Ofner S; Sosa MJ; Labarrere CA; Moe SM; American journal of nephrology, 2008 May 28

Disorders involving calcium, phosphorus, and magnesium.

Moe SM; Primary care, 2008 Jun

Association of hepatitis C virus infection with prevalence and development of kidney disease.

Moe SM; Pampalone AJ; Ofner S; Rosenman M; Teal E; Hui SL; American journal of kidney diseases : the official journal of the National Kidney Foundation, 2008 Apr 28

Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients--a pilot study.

Saifullah A; Watkins BA; Saha C; Li Y; Moe SM; Friedman AN; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007 Jul 10

Chronic kidney disease-mineral-bone disorder: a new paradigm.

Moe SM; Drüeke T; Lameire N; Eknoyan G; Advances in chronic kidney disease, 2007 Jan

Mechanisms of vascular calcification in chronic kidney disease.

Moe SM; Chen NX; Journal of the American Society of Nephrology : JASN, 2007 Dec 19

Vitamin D, cardiovascular disease, and survival in dialysis patients.

Moe SM; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2007 Dec

High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells.

Chen NX; Duan D; O'Neill KD; Moe SM; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2006 Sep 27

Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins.

Chen NX; O'Neill KD; Chen X; Duan D; Wang E; Sturek MS; Edwards JM; Moe SM; American journal of physiology. Renal physiology, 2006 Sep 12

Uremic vascular calcification.

Chen NX; Moe SM; Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2006 Nov

Vascular calcification: Hardening of the evidence.

Moe SM; Kidney international, 2006 Nov

Fish consumption and omega-3 fatty acid status and determinants in long-term hemodialysis.

Friedman AN; Moe SM; Perkins SM; Li Y; Watkins BA; American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006 Jun

The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells.

Chen NX; Duan D; O'Neill KD; Wolisi GO; Koczman JJ; Laclair R; Moe SM; Kidney international, 2006 Jul 12

Vascular calcification and renal osteodystrophy relationship in chronic kidney disease.

Moe SM; European journal of clinical investigation, 2006 Aug

The case against calcium-based phosphate binders.

Moe SM; Chertow GM; Clinical journal of the American Society of Nephrology : CJASN, 2006 Apr 26

Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States.

LaClair RE; Hellman RN; Karp SL; Kraus M; Ofner S; Li Q; Graves KL; Moe SM; American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005 Jun

Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD).

Moe SM; Reslerova M; Ketteler M; O'neill K; Duan D; Koczman J; Westenfeld R; Jahnen-Dechent W; Chen NX; Kidney international, 2005 Jun

Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl.

Moe SM; Cunningham J; Bommer J; Adler S; Rosansky SJ; Urena-Torres P; Albizem MB; Guo MD; Zani VJ; Goodman WG; Sprague SM; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005 Jul 19

The role of vitamin D in vascular calcification in chronic kidney disease.

Wolisi GO; Moe SM; Seminars in dialysis, 2005 Jul

[Vascular calcification in end stage renal disease].

Moe SM; Chen NX; Clinical calcium, 2002 Oct

American College of Physicians
American Medical Association
American Society for Clinical Investigation

American Board of Internal Medicine - Internal Medicine
American Board of Internal Medicine - Nephrology

My clinical interests focus on the prevention and treatment of kidney stones using diet and medications.  In addition I specialize in the treatment of bone disease in patients with kidney disease, and disorders of magnesium and calcium.