Pierre C. Dagher, MD
Professor of Medicine
Titles & Appointments
- Adjunct Professor of Cellular & Integrative Physiology
My lab investigates the mechanisms of acute kidney injury (AKI) in animal models of renal ischemia- reperfusion and sepsis. In particular, we study the interplay between tubular apoptosis, inflammation, metabolism and innate immunity in shaping the renal response to injury and therapy. We have identified guanine nucleotides, p53, macrophage subsets and Toll-like receptors as major modulators of the injury process, metabolism and tubular cross-talk as well as the post injury outcome and response to therapy. In addition to various biochemical, genetic and molecular approaches, we pioneered novel 2-photon intra vital microscopy techniques to study these processes in the live animal.