Neal X. Chen

Neal X. Chen, MD, PhD

Associate Research Professor of Medicine


Key Publications


Intracellular calcium increases in vascular smooth muscle cells with progression of chronic kidney disease in a rat model.

Rodenbeck SD, Zarse CA, McKenney-Drake ML, Bruning RS, Sturek M, Chen NX, Moe SM.

Nephrol Dial Transplant. 2017 Mar 1;32(3):450-458. doi: 10.1093/ndt/gfw274.


Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease.

Avin KG, Chen NX, Organ JM, Zarse C, O'Neill K, Conway RG, Konrad RJ, Bacallao RL, Allen MR, Moe SM.

PLoS One. 2016 Aug 3;11(8):e0159411. doi: 10.1371/journal.pone.0159411. eCollection 2016.


Calcitriol Suppression of Parathyroid Hormone Fails to Improve Skeletal Properties in an Animal Model of Chronic Kidney Disease.

Newman CL, Tian N, Hammond MA, Wallace JM, Brown DM, Chen NX, Moe SM, Allen MR.

Am J Nephrol. 2016;43(1):20-31. doi: 10.1159/000444423. Epub 2016 Feb 17.


Subcutaneous nerve activity and mechanisms of sudden death in a rat model of chronic kidney disease.

Zhao Y, Chen NX, Shirazi JT, Shen C, Lin SF, Fishbein MC, Moe SM, Chen PS.

Heart Rhythm. 2016 May;13(5):1105-12. doi: 10.1016/j.hrthm.2015.12.040. Epub 2015 Dec 29.


Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease.

Organ JM, Srisuwananukorn A, Price P, Joll JE, Biro KC, Rupert JE, Chen NX, Avin KG, Moe SM, Allen MR.

Nephrol Dial Transplant. 2016 Feb;31(2):223-30. doi: 10.1093/ndt/gfv352. Epub 2015 Oct 5.


Pathophysiology of Vascular Calcification.

Chen NX, Moe SM.

Curr Osteoporos Rep. 2015 Dec;13(6):372-80. doi: 10.1007/s11914-015-0293-9. Review.


Low Bone Turnover in Chronic Kidney Disease Is Associated with Decreased VEGF-A Expression and Osteoblast Differentiation.

Chen NX, O'Neill KD, Allen MR, Newman CL, Moe SM.

Am J Nephrol. 2015;41(6):464-73. doi: 10.1159/000438461. Epub 2015 Jul 25.


Differential miRNA Expression in Cells and Matrix Vesicles in Vascular Smooth Muscle Cells from Rats with Kidney Disease.

Chaturvedi P, Chen NX, O'Neill K, McClintick JN, Moe SM, Janga SC.

PLoS One. 2015 Jun 26;10(6):e0131589. doi: 10.1371/journal.pone.0131589. eCollection 2015.


Compromised vertebral structural and mechanical properties associated with progressive kidney disease and the effects of traditional pharmacological interventions.

Newman CL, Chen NX, Smith E, Smith M, Brown D, Moe SM, Allen MR.

Bone. 2015 Aug;77:50-6. doi: 10.1016/j.bone.2015.04.021. Epub 2015 Apr 17.


Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy.

Moe SM, Chen NX, Newman CL, Organ JM, Kneissel M, Kramer I, Gattone VH 2nd, Allen MR.

J Bone Miner Res. 2015 Mar;30(3):499-509. doi: 10.1002/jbmr.2372.


Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease.

Newman CL, Moe SM, Chen NX, Hammond MA, Wallace JM, Nyman JS, Allen MR.

PLoS One. 2014 Jun 9;9(6):e99262. doi: 10.1371/journal.pone.0099262. eCollection 2014.


Pathogenesis of arrhythmias in a model of CKD.

Hsueh CH, Chen NX, Lin SF, Chen PS, Gattone VH 2nd, Allen MR, Fishbein MC, Moe SM.

J Am Soc Nephrol. 2014 Dec;25(12):2812-21. doi: 10.1681/ASN.2013121343. Epub 2014 May 22.


Adipocyte induced arterial calcification is prevented with sodium thiosulfate.

Chen NX, O'Neill K, Akl NK, Moe SM.

Biochem Biophys Res Commun. 2014 Jun 20;449(1):151-6. doi: 10.1016/j.bbrc.2014.05.005. Epub 2014 May 10.


Adverse mandibular bone effects associated with kidney disease are only partially corrected with bisphosphonate and/or calcium treatment.

Allen MR, Chen NX, Gattone VH 2nd, Moe SM.

Am J Nephrol. 2013;38(6):458-64. doi: 10.1159/000356335. Epub 2013 Nov 22.


A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD.

Moe SM, Chen NX, Newman CL, Gattone VH 2nd, Organ JM, Chen X, Allen MR.

J Bone Miner Res. 2014 Apr;29(4):902-10. doi: 10.1002/jbmr.2089.


Decreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD).

Chen NX, Kiattisunthorn K, O'Neill KD, Chen X, Moorthi RN, Gattone VH 2nd, Allen MR, Moe SM.

PLoS One. 2013 May 22;8(5):e64558. doi: 10.1371/journal.pone.0064558. Print 2013.


Transglutaminase 2 accelerates vascular calcification in chronic kidney disease.

Chen NX, O'Neill K, Chen X, Kiattisunthorn K, Gattone VH, Moe SM.

Am J Nephrol. 2013;37(3):191-8. doi: 10.1159/000347031. Epub 2013 Feb 28.


Vascular calcification: pathophysiology and risk factors.

Chen NX, Moe SM.

Curr Hypertens Rep. 2012 Jun;14(3):228-37. doi: 10.1007/s11906-012-0265-8. Review.


The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.

Moe SM, Radcliffe JS, White KE, Gattone VH 2nd, Seifert MF, Chen X, Aldridge B, Chen NX.

J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485.

Free Article

Activation of arterial matrix metalloproteinases leads to vascular calcification in chronic kidney disease.

Chen NX, O'Neill KD, Chen X, Kiattisunthorn K, Gattone VH, Moe SM.

Am J Nephrol. 2011;34(3):211-9. doi: 10.1159/000330175. Epub 2011 Jul 23.

Free PMC Article

Calcimimetics inhibit renal pathology in rodent nephronophthisis.

Chen NX, Moe SM, Eggleston-Gulyas T, Chen X, Hoffmeyer WD, Bacallao RL, Herbert BS, Gattone VH 2nd.

Kidney Int. 2011 Sep;80(6):612-9. doi: 10.1038/ki.2011.139. Epub 2011 Jun 1.

Free Article

RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC).

Chen NX, Chen X, O'Neill KD, Atkinson SJ, Moe SM.

Am J Physiol Renal Physiol. 2010 Sep;299(3):F674-80. doi: 10.1152/ajprenal.00730.2009. Epub 2010 Jul 7.


Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells.

Chen NX, Kircelli F, O'Neill KD, Chen X, Moe SM.

Kidney Int. 2010 Mar;77(5):436-42. doi: 10.1038/ki.2009.481. Epub 2009 Dec 16.

Free Article

Calcimimetic inhibits late-stage cyst growth in ADPKD.

Gattone VH 2nd, Chen NX, Sinders RM, Seifert MF, Duan D, Martin D, Henley C, Moe SM.

J Am Soc Nephrol. 2009 Jul;20(7):1527-32. doi: 10.1681/ASN.2008090927. Epub 2009 May 7.


R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).

Moe SM, Seifert MF, Chen NX, Sinders RM, Chen X, Duan D, Henley C, Martin D, Gattone VH 2nd.

Nephrol Dial Transplant. 2009 Aug;24(8):2371-7. doi: 10.1093/ndt/gfp078. Epub 2009 Mar 3.


A rat model of chronic kidney disease-mineral bone disorder.

Moe SM, Chen NX, Seifert MF, Sinders RM, Duan D, Chen X, Liang Y, Radcliff JS, White KE, Gattone VH 2nd.

Kidney Int. 2009 Jan;75(2):176-84. doi: 10.1038/ki.2008.456. Epub 2008 Sep 17.


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