Brandon Gufford, PHMD, PhD
Assistant Professor of Medicine
R2 Room 402 CPHR
The goal of Dr. Gufford's translational research program is to improve the mechanistic understanding of interactions between conventional medications and natural products with a focus on patients infected with HIV. Our group is particularly interested in ways to better predict drug-drug and natural product-drug interactions that involve multiple components and active metabolites which alter drug disposition via multiple mechanisms. These complex interactions encompass simultaneous alteration of extrahepatic and hepatic metabolism and transport with the potential to cause adverse effects or be harnessed to yield therapeutic benefit. The complimentary tools used to understand these complex interactions include in vitro (bench research), in silico (computer modeling and simulation), and in vivo (clinical studies) approaches that span the gamut of the translational research spectrum.