43321-Meng, Fanyin

Fanyin Meng, MD, PhD

Associate Professor of Medicine

Indianapolis, IN


Dr. Fanyin Meng joined the Division of Gastroenterology and Hepatology in January, 2019 as the Associate Science Director of the Indiana Center for Liver Research (ICLR) and an Associate Professor with Tenure of Medicine. Dr. Meng joined IU School of Medicine from Texas A&M University College of Medicine, where he was an Associate Professor in the Department of Internal Medicine.

Dr. Meng is currently funded by US Department of Veterans Affairs (VA Merit Review Award), the National Institutes of Health (R01 & R21 grants) and PSC Partners Seeking a Cure.

Key Publications

Selected from 118 peer reviewed publications:  

1)        McDaniel K, Wu N, Zhou T, Huang L, Sato K, Venter J, Ceci L, Chen D, Ramos-Lorenzo S, Invernizzi P, Bernuzzi F, Wu C, Francis H, Glaser S, Alpini G, Meng F.  Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 knockout mice via let-7 microRNA.  Hepatology. 2019 Jun;69(6):2562-2578. doi: 10.1002/hep.30542. Epub 2019 Apr 12.  PMID:  30723922  

2)        Wu N, McDaniel K, Zhou T, Ramos-Lorenzo S, Wu C, Huang L, Chen D, Annable T, Francis H, Glaser S, Alpini G, Meng F. Knockout of microRNA-21 attenuates alcoholic hepatitis through VHL/NF-κB signaling pathway in hepatic stellate cells. American journal of physiology. Gastrointestinal and liver physiology. 2018; 315(3):G385-G398. PMID: 29848019.  

3)        Y Wan, K McDaniel, N Wu, S Ramos-Lorenzo, T Glaser, J Venter, H Francis, L Kennedy, K Sato, T Zhou, T Kyritsi, Q Huang, T Annable, S Glaser, C Wu, G Alpini, and F Meng.  Regulation of cellular senescence by miR-34a in alcoholic liver injury.  Am J Pathol 187: 2788-2798, 2017. 

4)   K McDaniel, L Huang, K Sato, N Wu, T Annable, T Zhou, S RamosLorenzo, Y Wan, Q Huang, H Francis, S Glaser, H Tsukamoto, G Alpini, and F Meng. The let-7/lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.  J Biol Chem 292:11336-11347, 2017.


Titles & Appointments

  • Associate Professor of Medicine
  • Adjunct Associate Professor of Anatomy, Cell Biology & Physiology
  • Adjunct Associate Professor of Biochemistry Molecular Biology
  • Education
    2003 MS University of Texas at Dallas
    1992 PhD 2nd Military Medical University
    1985 MD 2nd Military Medical University
  • Research

    My research program focuses on the pathogenesis of non-coding RNAs and extracellular vesicles regulated human cholestatic and alcoholic liver injuries and identifying new therapeutic avenues to treat these diseases. My work during the past 10 years has characterized non-coding RNA mediated pathogenetic pathways in vitro as well as in animal models that closely recapitulate the human cholestatic and alcoholic liver diseases and related malignancies. This work has been instrumental in the development of novel concepts about hepatobiliary regeneration/repair and the role of ncRNA in the initiation and perpetuation of alcoholic liver injury and liver cancer. My expertise in the field of cholestatic and alcoholic liver injuries in vitro as well as in animal models, coupled with a very dynamic research team and environment, enables me to be uniquely capable of shedding light on the role of ncRNA manipulation in the phenotypes of liver tissues and cells and their derived extracellular vesicles & non-coding RNAs as the novel therapeutic strategy in cholestatic and alcoholic liver diseases.

  • Professional Organizations
    American Association for the Study of Liver Diseases
    American Physiology Society
    American Society for Investigative Pathology (ASIP)
    American Society of Cell Biology
    International Association for the Study of the Liver
    International Society for Computational Biology
  • Awards
    Org: VA BLR&D
    Desc: VA BLR&D Merit Review Award
    Scope: National
    Date: 2012-07-01
    Org: CNSF
    Desc: CNSF Young Investigator Award
    Scope: International
    Date: 1994-05-01

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