Jason M. Spaeth, PhD
Assistant Professor of Pediatrics
Dr. Spaeth received his Bachelors of Science degree from Baylor University, PhD in Molecular Medicine from the University of Texas Health Science Center at San Antonio, and subsequently completed his postdoctoral fellowship in the Department of Molecular Physiology and Biophysics at Vanderbilt University.
During his postdoctoral fellowship with Roland Stein at Vanderbilt, Dr. Spaeth was funded by individual fellowships through the National Institutes of Health (NIH) and American Diabetes Association (ADA), and has developed tools to carry out his K01 Career Development Award from the NIH.
He launched his research program as an Assistant Professor in the Department of Pediatrics at Indiana University School of Medicine in 2019, where his research is centered on diabetes pathogenesis. He has a special emphasis on how transcriptional coregulators modulate activities of islet enriched transcription factors critical for pancreas formation and islet beta cell function.
Spaeth Lab Website: https://jspaeth4.wixsite.com/spaethlab
Ped-Endocrinology Basic Res
R4 104 PENB
The Spaeth Lab focuses on the pathogenesis of diabetes mellitus and islet cell function, with emphasis on understanding how coregulators modulate the activities of islet-enriched transcription factors under normal and pathophysiological settings of Type 1 and Type 2 diabetes. Specifically, the lab is interested in the Pancreas and Duodenal Homeobox 1 (Pdx1) transcription factor, previously shown to be essential for pancreatogenesis, islet beta cell development and function.